Results 191 to 200 of about 100,511 (312)

Comparative effectiveness and safety of oral anticoagulants in patients with atrial fibrillation using antiarrhythmic drugs: An international cohort study. [PDF]

Br J Clin Pharmacol
Meinert FM, Dimakos J, Cui Y, Filion KB, Renoux C, Douros A.   +5 more
europepmc   +1 more source

Investigational antiarrhythmic agents: promising drugs in early clinical development

Expert Opinion on Investigational Drugs, 2017
J. Heijman, Shokoufeh Ghezelbash, D. Dobrev   +2 more
semanticscholar   +1 more source

Possible Deslanoside‐Induced Left Posterior Fascicular Ventricular Tachycardia: A Case Report

Annals of Noninvasive Electrocardiology, Volume 31, Issue 3, May 2026.
A 73‐year‐old man with paroxysmal AF and no structural heart disease who developed left posterior fascicular ventricular tachycardia (LPFVT) shortly after intravenous Deslanoside administration for rate control. Highlights: cardiac glycosides, though effective for rate control, may occasionally precipitate Purkinje‐related ventricular tachycardia ...
Zhang Wenjun, Chen Yao
wiley   +1 more source

Efficacy of ranolazine in reducing complex premature ventricular contractions in a patient with mitral valve prolapse: a case report. [PDF]

Eur Heart J Case Rep
Tarantino N, Tio K, Schenone A, Di Biase L.   +3 more
europepmc   +1 more source

Radiofrequency ablation vs antiarrhythmic drugs as first-line treatment of paroxysmal atrial fibrillation (RAAFT-2): a randomized trial.

Journal of the American Medical Association (JAMA), 2014
C. Morillo, A. Verma, S. Connolly, K. Kuck, G. Nair, J. Champagne, L. Sterns, H. Beresh, J. Healey, A. Natale   +9 more
semanticscholar   +1 more source

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, Volume 183, Issue 9, Page 1939-1957, May 2026.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source

From allergy to arrhythmia - electrophysiological basis for the antiarrhythmic properties of antazoline. [PDF]

Front Pharmacol
Wiedmann F, Prodanova A, Kraft M, Weitkamp FM, Paasche A, Goetz C, Schmidt C.   +6 more
europepmc   +1 more source

Opening closed inward rectifier potassium channel doors

British Journal of Pharmacology, Volume 183, Issue 10, Page 2197-2218, May 2026.
Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger, Fabian Kaiser, Marcel A. G. van der Heyden, Saïd Bendahhou   +3 more
wiley   +1 more source

Synergistic antiarrhythmic mechanism of I_Na-L and RyR2 blockade: normalization of pathological calcium cycling and CaMKII signaling. [PDF]

J Transl Med
Ju M, Qiu S, Wang Y, Wu W, Sun J, Shi C, Jia Q, Xu Y.   +7 more
europepmc   +1 more source

Machine Learning‐Based Prediction of Drug‐Induced QTc Changes in a Large Finnish Biobank Cohort

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Prolongation of the QT interval is a known precursor to serious arrhythmias and sudden cardiac death, often triggered by medication use. Current medication risk evaluation platforms rely on literature‐based synthesis and may lag behind real‐world developments.
Ville Langén, Aleksi Winstén, Konsta Teppo, Timo Pohjonen, Jari Laukkanen, Arto Mannermaa, Teemu J. Niiranen, Joonatan Palmu   +7 more
wiley   +1 more source