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Metabolism of Antiarrhythmics

Current Drug Metabolism, 2004
Antiarrhythmics are a group of drugs that manage the irregular electrical activity of the heart. Their use in the clinic is made difficult by their narrow therapeutic index. The disposition of antiarrhythmics is dependent on many factors, such as administration route, stereoselectivity in the first-pass effect, inhibition of enzymes, polymorphisms, etc.
Huy Riem, Ha, Ferenc, Follath
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