Results 31 to 40 of about 17,282 (226)

DYNAMICS OF THE HEART RATE VARIABILITY IN PATIENTS WITH ATRIAL FIBRILLATION DURING ATORVASTATIN THERAPY

open access: yesРациональная фармакотерапия в кардиологии, 2016
Aim. To evaluate the heart rate variability (HRV) in patients with ischemic heart disease (IHD) and paroxysmal atrial fibrillation (AF) during atorvastatin therapy.Material and methods.
E. S. Kozlova   +3 more
doaj   +1 more source

Rate-Control or Rhythm-Contol: Where do we stand? [PDF]

open access: yes, 2005
Atrial fibrillation is the most common sustained rhythm disturbance and its prevalence is increasing worldwide due to the progressive aging of the population.
A, Dello Russo   +6 more
core   +1 more source

Endothelin and the ischaemic heart [PDF]

open access: yes, 2005
Soon after its identification as a powerful vasoconstrictor peptide, endothelin (ET-1) was implicated as a detrimental agent involved in determining the outcome of myocardial ischaemia and reperfusion.
Kane, K.A., McCabe, C., Wainwright, C.L.
core   +1 more source

Targeted Anti‐IL‐1 Immunomodulatory Therapy in Pediatric Onset PPP1R13L‐Related Arrhythmogenic Cardiomyopathy

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal recessive loss‐of‐function variants in PPP1R13L cause an ultra‐rare cardiocutaneous syndrome characterized by rapidly progressive arrhythmogenic cardiomyopathy (ACM). PPP1R13L encodes iASPP, which has two potentially overlapping mechanisms driving ACM as both a regulator of NFκB‐mediated inflammation and a binding partner within the ...
Aaron Renberg   +9 more
wiley   +1 more source

Micro-RNA family that modulates fibrosis and uses thereof [PDF]

open access: yes, 2017
The present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29 family are down-regulated in the heart tissue in response
Olson, Eric N., van Rooij, Eva
core   +1 more source

Resolution of Refractory Multifocal Atrial Tachycardia in Costello Syndrome Using Trametinib: A Case Supporting MEK Inhibitors as Targeted, Specific Antiarrhythmic

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Arrhythmias affect approximately half of patients with Costello syndrome (CS, OMIM # 218040), with non‐reentrant atrial tachycardia being the most common. This case describes an infant with Costello syndrome carrying the pathogenic HRAS c.34G>A (p.G12S) variant who developed early‐onset, drug‐refractory multifocal atrial tachycardia (MAT ...
Vanina Taliercio   +11 more
wiley   +1 more source

Safety issues of antiarrhythmic therapy for atrial fibrillation

open access: yesКлинический разбор в общей медицине
The article discusses the safety of antiarrhythmic therapy for atrial fibrillation in the light of the development of cardiac and non-cardiac side effects, the presence of drug-drug interactions of antiarrhythmic drugs in the near (with anticoagulants ...
I.I. Reznik , Ya.G. Bozhko
doaj   +1 more source

Future evaluation of antiarrhythmic therapy

open access: yesAmerican Heart Journal, 1994
The expansion of antiarrhythmic therapy beyond pharmacologic agents to include surgery, devices, and ablation procedures, plus the reaffirmation by the Cardiac Arrhythmia Suppression Trial (CAST) of the need for concurrent placebo-controlled trials to establish a mortality benefit, have resulted in the need to consider the requirements for evaluating ...
R J, Myerburg   +6 more
openaire   +2 more sources

Role of pharmacotherapy in Brugada syndrome [PDF]

open access: yes, 2004
In patients who undergo aborted sudden cardiac death or syncope of unknown origin (symptomatic Brugada syndrome), no one argues that the implantation of an ICD is the first-line therapy regardless of the findings of the EP study.
Tsuchiya, Takeshi
core   +1 more source

Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga   +20 more
wiley   +1 more source

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