Results 61 to 70 of about 2,377,916 (241)

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Therapy for patient with atrial fibrillation: in search of a balance between efficacy and safety

Клинический разбор в общей медицине
This paper analyzes aspects of the efficacy and safety of antiarrhythmic drugs in the treatment of atrial fibrillation. It considers drug-drug interactions of antiarrhythmics with other drugs, especially in the near circle, i.e.
Yakov G. Bozhko, Inna I. Reznik, Mikhail V. Arkhipov   +2 more
doaj   +1 more source

Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay, Lynn C. Lunsonga, Peter E. Light, Khaled Barakat   +3 more
wiley   +1 more source

Antiarrhythmic drug therapy to treat atrial fibrillation. [PDF]

, 2012
Tijekom zadnjih 10 godina uložen je značajan trud u utvrđivanju uloge antiaritmičkog liječenja za održavanje sinusnog ritma kod pacijenata s fibrilacijom atrija (FA). Podaci randomiziranih kontroliranih studija su pokazali da strategija kontrole ritma, u
Dubravko Petrač, Petrač, Dubravko
core   +1 more source

Bayesian meta-analysis on medical devices: Application to implantable cardioverter defibrillators [PDF]

, 2012
The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution-NonCommercial-ShareAlike licence .
Girling, Alan, Buxton, M., Girling, A, Lord, J., Youn, J.H., Hemming, K, Hemming, K., Girling, A., Lord, Joanne, Buxton, M, Youn, J-H, Hemming, Karla; id_orcid, Lord, J, Youn, Ji-Hee, Buxton, Martin   +14 more
core   +1 more source

Integrative Approaches in Cardiovascular Disease: The Role of Nutraceuticals in Heart Failure, Atrial Fibrillation, and Related Conditions

Phytotherapy Research, EarlyView.
Schematic representation of the shared pathophysiological mechanisms underlying heart failure (HF) and atrial fibrillation (AF), including inflammation, oxidative stress, endothelial dysfunction, and fibrosis. The figure highlights the clinical and mechanistic convergence of conventional pharmacological therapies and selected nutraceuticals in ...
Laura Beatrice Mattioli, Ivan Corazza, Roberta Budriesi, Luca Camarda, Maria Carelli, Alberto Spadotto, Igor Diemberger   +6 more
wiley   +1 more source

Antiarrhythmic drug therapy during cardiopulmonary resuscitation:Should we use it?

, 2018
Purpose of review The optimal antiarrhythmic drug therapy (amiodarone or lidocaine) in the treatment of ventricular fibrillation/pulseless ventricular tachycardia (VF/pVT) cardiac arrest that is refractory to defibrillation is uncertain.
Jasmeet Soar, Soar, Jasmeet
core   +1 more source

Cardiotoxicity of BRAF/MEK inhibitors

British Journal of Pharmacology, EarlyView.
Abstract Rapidly accelerated fibrosarcoma type B/B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) and mitogen‐activated protein kinase (MEK) inhibitors have transformed outcomes in cancer therapy, particularly in melanoma. However, cardiovascular toxicities are increasingly recognized in real‐world clinical practice.
Katharina Seuthe, Valerie Lohner, Kevin Terre, Thomas Riffelmacher, Roman Pfister   +4 more
wiley   +1 more source

Arrhythmias associated with immune checkpoint inhibitor therapy—A clinical perspective

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but are associated with a growing spectrum of cardiovascular immune‐related adverse events. Among these, arrhythmias represent a rare yet potentially life‐threatening complication. ICI‐induced arrhythmias encompass a wide clinical spectrum, including atrial arrhythmias, conduction ...
Dong Wang, Melanie Ricke‐Hoch, David Duncker, Johann Bauersachs, Dominik Berliner   +4 more
wiley   +1 more source

A pharmacotherapy of atrial fibrillation in subclinical thyrotoxicosis

Известия высших учебных заведений. Поволжский регион: Медицинские науки, 2021
Background. Pharmacological therapy of atrial fibrillation (AF) in subclinical dysfunction of the thyroid – is the most important problem of modern clinical medicine.
R.F. Rakhmatullov, L.V. Mel'nikova, I.Ya. Moiseeva, F.K. Rakhmatullov   +3 more
doaj   +1 more source