Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes
The Journal of Physiology, EarlyView.Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière +6 more
wiley +1 more source
Statins and their antiarrhythmic activity
Кардиоваскулярная терапия и профилактика, 1970 Clinical trials of modern antiarrhythmics often demonstrate their ineffectiveness in life-threatening ventricular arrhythmias and sudden cardiac death (SCD), as well as inadequate pharmacological control in atrial fibrillation (AF).
N. Sh. Zagidullin +2 more
doaj
Basic examination on drug level analysis in hair of antiarrhythmic drug flecainide.
, 1999 Yoshinori Takiguchi
openalex +2 more sources
Sildenafil helps the beat go on
Experimental Physiology, EarlyView.
Jules C. Hancox
wiley +1 more source
Selective RyR2 inhibition reduces arrhythmia susceptibility in human cardiac slices
The Journal of Physiology, EarlyView.Abstract figure legend ent‐Vert selectively inhibits RyR2‐mediated sarcoplasmic reticulum (SR) Ca2+ leak and prevents triggered activity in human cardiac slices. A, in human ventricular slices exposed to β‐adrenergic stimulation with Iso and RyR2 sensitization with caffeine, RyR2 channels become hyperactive, leading to Ca2+ sarcoplasmic leak and ...
Micah K. Madrid +6 more
wiley +1 more source
A Prospective Analysis of Adverse Drug Reactions in a South Indian Hospital [PDF]
, 2009 Adverse drug reactions are a great cause of concern to the medical profession, the patients and the pharmaceutical industry. However ADR reporting and monitoring is yet to catch up in India.
Adhikari, P, Padmaja, U, Pereira, P
core
Antiarrhythmic Mechanisms of Epidural Blockade After Myocardial Infarction [PDF]
Jonathan D. Hoang +8 more
openalex +1 more source
VErapamil Plus Antiarrhythmic drugs Reduce Atrial Fibrillation recurrences after an electrical cardioversion (VEPARAF Study) [PDF]
, 2003 Antonio De Simone
openalex +1 more source
Identifying Drugs Associated With Parkinson's Disease Risk Using Machine Learning
Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.ABSTRACT Machine learning (ML)–based methods have been proposed as a potential approach for identifying candidate drugs to be repurposed as disease‐modifying treatments for Parkinson's disease (PD). We applied an ML‐based signal detection method to identify drugs associated with PD and evaluated the method's generalizability.
Eeva Pylkkö +8 more
wiley +1 more source
Single-chamber Versus Dual-chamber Implantable Cardioverter Defibrillators: Do We Need Physiologic Pacing in The Course? [PDF]
, 2006 Background: Many patients with ICD receive different antiarrhythmic drugs (e.g. sotalol, amiodarone, β-blockers) because of ventricular or atrial tachycardias.
Buck, Thomas +4 more
core +2 more sources