Results 231 to 240 of about 44,802 (314)

Anti‐cancer drugs targeting the NADH‐binding site of VDAC rewire channel electrophysiology and partially suppress cation selectivity

The FEBS Journal, Volume 293, Issue 12, Page 3663-3682, June 2026.
VA molecules alter VDAC1 gating by increasing anion flow and reducing cation permeability. In cancer cells, which rely on ER‐mitochondria Ca2+ transfer and overexpress VDAC1, this imbalance triggers bioenergetic stress, ROS buildup, and mitochondrial collapse, leading to cell death.
Stefano Conti‐Nibali, Giuseppe Battiato, Salvatore Antonio Maria Cubisino, Cristina Arrigoni, Marco Lolicato, Simona Reina, Vito De Pinto   +6 more
wiley   +1 more source

Wise Prescriptions: Prevalence and Predictors of Polypharmacy in Patients with Type 2 Diabetes Mellitus in Primary Care: A Retrospective Cross-Sectional Study. [PDF]

J Clin Med
Alsultan MM, Al Thani DR, Shwaiheen SA, Al Drees EA, Al Drees MA, AlQahtani RD, Alnubi AA, Alali SY, AlQarni AM.   +8 more
europepmc   +1 more source

A Comprehensive Assessment of Renal Function During and After Pulsed Field Ablation

Journal of Cardiovascular Electrophysiology, Volume 37, Issue 6, Page 1259-1267, June 2026.
ABSTRACT Background Acute kidney injury is an uncommon complication of pulsed field ablation (PFA). There is, however, limited empirical data on the dynamics of renal biomarkers apart from creatinine. Furthermore, no study to date has assessed creatinine at more than 24 h after the procedure. Methods Patients undergoing PFA for atrial fibrillation (AF)
Václav Melenovský, Marek Hozman, Sabri Hassouna, Ivana Fišerová, Barbora Bačová, Dalibor Heřman, Jakub Karch, Jana Veselá, Michal Zuzčák, Ivan Rychlík, Pavel Osmančík   +10 more
wiley   +1 more source

Efficacy of ranolazine in reducing complex premature ventricular contractions in a patient with mitral valve prolapse: a case report. [PDF]

Eur Heart J Case Rep
Tarantino N, Tio K, Schenone A, Di Biase L.   +3 more
europepmc   +1 more source

Comparison of HEMOlysis Markers Among Three Pulsed Field Ablation Systems: HEMO‐PFA Study

Journal of Cardiovascular Electrophysiology, Volume 37, Issue 6, Page 1249-1258, June 2026.
ABSTRACT Background Pulsed field ablation (PFA) has emerged as a novel non‐thermal modality for atrial fibrillation (AF) ablation. While hemolysis is a known complication of PFA, comparative data among different systems remain limited. Methods We prospectively enrolled 150 consecutive AF patients undergoing ablation with one of three PFA systems ...
Kazuhisa Matsumoto, Kei Matsumoto, Naomichi Tanaka, Wataru Sasaki, Tsukasa Naganuma, Masataka Narita, Hitoshi Mori, Yoshifumi Ikeda, Takahide Arai, Shintaro Nakano, Kazuo Matsumoto, Ritsushi Kato   +11 more
wiley   +1 more source

Advanced management of electrical storm: beyond antiarrhythmics. [PDF]

BMJ Case Rep
Jakulla RS, Almohtasib Y, Garcia RA, Gupta S.   +3 more
europepmc   +1 more source

Food Insecurity Among Medicare Beneficiaries in 2017–2022: A Longitudinal Cohort Study

Journal of the American Geriatrics Society, Volume 74, Issue 6, Page 1626-1637, June 2026.
ABSTRACT Background Food insecurity affects many older adults and is associated with a range of adverse health outcomes. However, most prior research has relied on cross‐sectional data, and evidence on predictors of subsequent food insecurity among Medicare beneficiaries remains limited. Methods We conducted a retrospective longitudinal cohort study of
David D. Kim, Charles J. Duncan, Elliott Crummer   +2 more
wiley   +1 more source

Impact of left ventricular ejection fraction on clinical outcomes following ventricular tachycardia ablation: a propensity-matched analysis from a large multicentre database. [PDF]

Eur Heart J Open
Dulal D, Maraey A, Chacko P, Dhanjal T, Maan A, Heist EK.   +5 more
europepmc   +1 more source

Factors associated with potentially inappropriate medication use, medication underuse and overuse in older adults in the German National Cohort

Journal of Internal Medicine, Volume 299, Issue 6, Page 754-775, June 2026.
Abstract Background Effectively identifying individuals exposed to drug underuse, overuse and potentially inappropriate medication (PIM) in older adults is essential for minimizing preventable drug‐related harms. Methods We analysed data from 54,296 individuals aged 60–74 years from the German National Cohort (NAKO).
Miriam Degen, Ulrike Haug, Oliver H. F. Scholle, Yaw Awuku‐Larbi, Sigrid Carlsson, Nina Ebert, Volker Harth, Anja M. Hauri, Margit Heier, Anne Herrmann, Michael Leitzmann, Jakob Linseisen, Claudia Meinke‐Franze, Nadia Obi, Phil Pendt, Thomas Reinhold, Barbara Thorand, Hermann Brenner, Ben Schöttker   +18 more
wiley   +1 more source

Combined Endocardial Radiofrequency and Pulsed-Field Left Ventricular Summit Ablation: With Great Power Comes Great Responsibility. [PDF]

JACC Case Rep
Guandalini GS.
europepmc   +1 more source