Results 1 to 10 of about 10,489 (201)

A Streamlined High Performance Liquid Chromatography with Tandem Mass Spectrometry Based Workflow for Rapid Screening of Cellular Accumulation of Small Molecules. [PDF]

ChemMedChem
This study uses six small‐molecule inhibitors to evaluate optimal cellular accumulation assay conditions in a 96‐well format with high performance liquid chromatography with tandem mass spectrometry detection. The obtained medium to high‐throughput workflow is suitable for reliably identifying cellular accumulation, valuable for preclinical selection ...
Metzen A, Rox K.
europepmc   +2 more sources

Chemoenzymatically Synthesized O-Acetylated GD3 Gangliosides to Examine Viral Receptor Specificities in a Cellular Context. [PDF]

Angew Chem Int Ed Engl
7‐O‐, 9‐O‐, and 7,9‐di‐O‐acetylated GD3 gangliosides can be prepared by chemical assembly of a tetrasaccharide as α‐glycosyl fluoride that is coupled to sphingosine using a glycosynthase, followed by O‐acetyl editing by coronaviral hemagglutinin‐esterases (HEs).
Zhang Z, Liang R, Hooijschuur KC, de Vries RP, Li Z, Boons GJ.   +5 more
europepmc   +3 more sources

Fever, Syncope, and the Brugada Dilemma: Navigating the Complexities of ICD Decision-Making in an Atypical Presentation. [PDF]

Case Rep Cardiol
Brugada syndrome (BrS) is a rare inherited cardiac channelopathy associated with ventricular arrhythmias and sudden cardiac death (SCD), often in individuals with structurally normal hearts.
Devkota L, Hoffer-Hawlik M, Yang F, Jung AS.   +3 more
europepmc   +2 more sources

Oral procainamide as pharmacological treatment of recurrent and refractory ventricular tachyarrhythmias: A single-center experience

Heart Rhythm O2, 2021
Background: Antiarrhythmic therapy for recurrent ventricular arrhythmias in patients who have undergone catheter ablation, and in whom amiodarone and/or beta-blockers were ineffective or contraindicated, is a controversial issue.
Mauro Toniolo, MD, Daniele Muser, MD, Giulia Grilli, MD, Massimo Burelli, MD, Luca Rebellato, MD, Elisabetta Daleffe, MD, Domenico Facchin, MD, Massimo Imazio, MD   +7 more
doaj   +1 more source

Bolus Intravenous Procainamide in Patients with Frequent Ventricular Ectopics during Cardiac Magnetic Resonance Scanning: A Way to Ensure High Quality Imaging

Diagnostics, 2021
Acquiring high-quality cardiac magnetic resonance (CMR) images in patients with frequent ventricular arrhythmias remains a challenge. We examined the safety and efficacy of procainamide when administered on the scanner table prior to CMR scanning to ...
Chrysovalantou Nikolaidou, Konstantinos Kouskouras, Nikolaos Fragakis, Vassilios P. Vassilikos, Haralambos Karvounis, Theodoros D. Karamitsos   +5 more
doaj   +1 more source

Procainamide Inhibits DNA Methylation and Alleviates Multiple Organ Dysfunction in Rats with Endotoxic Shock. [PDF]

PLoS ONE, 2016
Excessive inflammatory and oxidative stress lead to circulatory failure, multiple organ dysfunction, and high mortality in patients with sepsis. Microbial infection-induced DNA hypermethylation is associated with the augmentation of inflammation and ...
Chih-Chin Shih, Mei-Hui Liao, Tsan-Seng Hsiao, Hiong-Ping Hii, Ching-Hui Shen, Shiu-Jen Chen, Shuk-Man Ka, Yung-Lung Chang, Chin-Chen Wu   +8 more
doaj   +1 more source

Synthesis of 4-Amino-N-[2 (diethylamino)Ethyl]Benzamide Tetraphenylborate Ion-Associate Complex: Characterization, Antibacterial and Computational Study

Molecules, 2023
The 4-amino-N-[2 (diethylamino) ethyl] benzamide (procainamide)-tetraphenylborate complex was synthesized by reacting sodium tetraphenyl borate with 4-amino-N-[2 (diethylamino) ethyl] benzamide, chloride salt, and procainamide in deionized water at room ...
Gamal A. E. Mostafa, Ahmed H. Bakheit, Mohamed H. Al-Agamy, Rashad Al-Salahi, Essam A. Ali, Haitham Alrabiah   +5 more
doaj   +1 more source

Effects of 1α,25-Dihydroxyvitamin D₃ on the Pharmacokinetics of Procainamide and Its Metabolite N-Acetylprocainamide, Organic Cation Transporter Substrates, in Rats with PBPK Modeling Approach

Pharmaceutics, 2021
In this study, possible changes in the expression of rat organic cationic transporters (rOCTs) and rat multidrug and toxin extrusion proteins (rMATEs) following treatment with 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) were investigated.
Anusha Balla, Yoo-Seong Jeong, Hyo-Jung Kim, Yun-Jong Lee, Suk-Jae Chung, Yoon-Jee Chae, Han-Joo Maeng   +6 more
doaj   +1 more source

Development of multifocal atrial tachycardia in a patient using aminophylline -A case report- [PDF]

Korean Journal of Anesthesiology, 2010
An 82-year-old female, with left femoral neck fracture was scheduled for left hip hemiarthroplasty, under spinal anaesthesia. She had been suffering from diabetes, hypertension, lung cancer and was previously treated with IV aminophylline for respiratory
Lee Kyoung Kim, Chul Seung Lee, Jun Gong Jeun   +2 more
doaj   +1 more source

Differentiated approach to rhythm conversion in patients with atrial fibrillation and flutter

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2021
The importance of relieving paroxysms of fibrillation and atrial flutter is determined by a huge number of patients suffering from this pathology and its recurrent course.Objective: To create an algorithm for the treatment of patients with atrial ...
A. G. Pronin, A. V. Prokopenko, D. K. Glukhov   +2 more
doaj   +1 more source