Results 21 to 30 of about 10,489 (201)

Physiologically-Based Pharmacokinetic Modeling for Drug-Drug Interactions of Procainamide and N-Acetylprocainamide with Cimetidine, an Inhibitor of rOCT2 and rMATE1, in Rats

open access: yesPharmaceutics, 2019
Previous observations demonstrated that cimetidine decreased the clearance of procainamide (PA) and/or N-acetylprocainamide (NAPA; the primary metabolite of PA) resulting in the increased systemic exposure and the decrease of urinary excretion.
Yoo-Seong Jeong   +4 more
doaj   +1 more source

Simultaneous Determination of Procainamide and N-acetylprocainamide in Rat Plasma by Ultra-High-Pressure Liquid Chromatography Coupled with a Diode Array Detector and Its Application to a Pharmacokinetic Study in Rats

open access: yesPharmaceutics, 2018
A simple, sensitive, and reliable reversed-phase, Ultra-High-Pressure Liquid Chromatography (UHPLC) coupled with a Diode Array Detector (DAD) method for the simultaneous determination of Procainamide (PA) and its major metabolite, N-acetylprocainamide ...
Anusha Balla   +3 more
doaj   +1 more source

Unmasked by Fever: Diagnosing Brugada Syndrome After Ventricular Fibrillation Arrest

open access: yesAnnals of Internal Medicine: Clinical Cases, 2023
A 65-year-old man presented to the emergency department after he was resuscitated from cardiac arrest due to ventricular fibrillation. Coronary angiography demonstrated no evidence of coronary artery disease. Follow-up electrocardiograms (ECGs) were also
Theodore Peng   +3 more
doaj   +1 more source

Medical treatment of cardiac arrhythmias in Chagas'heart disease [PDF]

open access: yes, 1995
There are no controlled clinical trials evaluating drug therapy in patients with ventricular arrhythmias and chronic chagasic cardiomyopathy. Empirical treatment with disopyramide (400-1,000mg/d), phenytoin (4-6mg/d), mexiletine (600-1,200mg/d ...
De Paola, Angelo Amato Vincenzo   +3 more
core   +1 more source

Rate-controlled rectal drug delivery in man with a hydrogel preparation [PDF]

open access: yes, 1986
Cylindrical hydrogels of hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) as crosslinking agent were prepared by radical polymerization at 70°C.
Boer, A.G. de   +4 more
core   +3 more sources

Design of Intelligent Molecules as Models for Production of New Anti-alzheimer´s Medicines Using Epigenetic Modulation

open access: yesChemical Engineering Transactions, 2019
Alzheimer's disease is a neurodegenerative illness, so far without cure, that affects an increasing number of people around the world. Due to the adverse effects caused by drugs for treating this disease currently in clinical use, it is necessary to ...
Geane Oliveira   +4 more
doaj   +1 more source

Diagnosis and management of junctional ectopic tachycardia in children

open access: yesAnnals of Pediatric Cardiology, 2021
Junctional ectopic tachycardia (JET) is more common in its postoperative form. A thorough understanding of its etiology, pathophysiology, and management strategies is essential.
Navaneetha Sasikumar   +2 more
doaj   +1 more source

Brugada Syndrome: Presentation and Management of the Atypical Patient in the Emergent Setting [PDF]

open access: yes, 2020
Introduction: Brugada syndrome is a genetic disorder of the heart’s electrical system that increases a patient’s risk of sudden cardiac death. It is a syndrome most prevalent in Southeast Asians and is found 36 times more commonly in Asians than in ...
Flores, Mario   +2 more
core  

Left atrial size after cardioversion for atrial fibrillation: effect of external DC shock [PDF]

open access: yes, 2003
OBJECTIVE: The aim of this study was to evaluate the effect of external direct current (DC) shock on left atrial (LA) dimension and volumes after cardioversion for atrial fibrillation, and the relation between LA size and atrial function.
L. Bonetti   +3 more
core   +1 more source

Cyclodextrin potentiometric sensors based on selective recognition sites for procainamide: Comparative and theoretical study

open access: yesOpen Chemistry, 2019
Polyvinyl chloride (PVC) membrane sensors were constructed and developed for the determination of procainamide HCl (PR). Three membrane sensors incorporating α-, β- and γ- cyclodextrin (CD) as ionophores with potassium tetrakis (4-chlorophenyl) borate ...
AlRabiah Haitham   +3 more
doaj   +1 more source

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