Physiologically-Based Pharmacokinetic Modeling for Drug-Drug Interactions of Procainamide and N-Acetylprocainamide with Cimetidine, an Inhibitor of rOCT2 and rMATE1, in Rats [PDF]
Pharmaceutics, 2019 Previous observations demonstrated that cimetidine decreased the clearance of procainamide (PA) and/or N-acetylprocainamide (NAPA; the primary metabolite of PA) resulting in the increased systemic exposure and the decrease of urinary excretion.
Anusha Balla +2 more
exaly +4 more sources
Simultaneous Determination of Procainamide and N-acetylprocainamide in Rat Plasma by Ultra-High-Pressure Liquid Chromatography Coupled with a Diode Array Detector and Its Application to a Pharmacokinetic Study in Rats [PDF]
Pharmaceutics, 2018 A simple, sensitive, and reliable reversed-phase, Ultra-High-Pressure Liquid Chromatography (UHPLC) coupled with a Diode Array Detector (DAD) method for the simultaneous determination of Procainamide (PA) and its major metabolite, N-acetylprocainamide ...
Anusha Balla, Yu Chul Kim, Han-Joo Maeng
exaly +4 more sources
Effects of 1α,25-Dihydroxyvitamin D3 on the Pharmacokinetics of Procainamide and Its Metabolite N-Acetylprocainamide, Organic Cation Transporter Substrates, in Rats with PBPK Modeling Approach [PDF]
Pharmaceutics, 2021 In this study, possible changes in the expression of rat organic cationic transporters (rOCTs) and rat multidrug and toxin extrusion proteins (rMATEs) following treatment with 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) were investigated.
Anusha Balla +6 more
doaj +2 more sources
Utility, promise, and limitations of liquid chromatography‐mass spectrometry‐based therapeutic drug monitoring in precision medicine [PDF]
Journal of Mass Spectrometry, Volume 56, Issue 11, November 2021., 2021 Abstract Therapeutic drug monitoring (TDM) is typically referred to as the measurement of the concentration of drugs in patient blood. Although in the past, TDM was restricted to drugs with a narrow therapeutic range in order to avoid drug toxicity, TDM has recently become a major tool for precision medicine being applied to many more drugs.
Vanessa P. Gaspar +3 more
wiley +2 more sources
Pediatric antiarrhythmics and toxicity: A clinical review [PDF]
Journal of the American College of Emergency Physicians Open, Volume 5, Issue 1, February 2024.Abstract Antiarrhythmic medications are fundamental in the acute and chronic management of pediatric arrhythmias. Particularly in the pediatric patient population, associated antiarrhythmic toxicities represent important potential adverse effects. Emergency medicine clinicians must be skilled in the detection, workup, and management of antiarrhythmic ...
Alexandra T. Geanacopoulos +6 more
wiley +2 more sources
Molecular basis of the different effects of procainamide and N-acetylprocainamide on the maximum upstroke velocity and half-decay time of the cardiac action potential in guinea pig papillary muscle. [PDF]
Braz J Med Biol Res, 2023 Sigler W, Oliveira AC.
europepmc +1 more source
Management of acute supraventricular tachycardia in children. [PDF]
Can Fam Physician, 2023 Abbasi E, Vijayashankar SS, Goldman RD.
europepmc +1 more source
Combination Therapy of Ivabradine with Procainamide for the Management of Pediatric Postoperative Junctional Ectopic Tachycardia. [PDF]
J Innov Card Rhythm Manag, 2023 Dasgupta S, Johnsrude C.
europepmc +1 more source
Improving the specificity of drug-drug interaction alerts: Can it be done? [PDF]
Am J Health Syst Pharm, 2022 Reese T +7 more
europepmc +1 more source
Procainamide for the Rapid Suppression of Premature Ventricular Contractions: An (Almost) Forgotten Tool in the Cardiologist's Armamentarium. [PDF]
Diagnostics (Basel), 2021 Muser D, Santangeli P, Nucifora G.
europepmc +1 more source