Results 1 to 10 of about 455 (155)

Physiologically-Based Pharmacokinetic Modeling for Drug-Drug Interactions of Procainamide and N-Acetylprocainamide with Cimetidine, an Inhibitor of rOCT2 and rMATE1, in Rats [PDF]

Pharmaceutics, 2019
Previous observations demonstrated that cimetidine decreased the clearance of procainamide (PA) and/or N-acetylprocainamide (NAPA; the primary metabolite of PA) resulting in the increased systemic exposure and the decrease of urinary excretion.
Yoo-Seong Jeong, Anusha Balla, Kwang-Hoon Chun   +2 more
exaly   +4 more sources

Simultaneous Determination of Procainamide and N-acetylprocainamide in Rat Plasma by Ultra-High-Pressure Liquid Chromatography Coupled with a Diode Array Detector and Its Application to a Pharmacokinetic Study in Rats [PDF]

Pharmaceutics, 2018
A simple, sensitive, and reliable reversed-phase, Ultra-High-Pressure Liquid Chromatography (UHPLC) coupled with a Diode Array Detector (DAD) method for the simultaneous determination of Procainamide (PA) and its major metabolite, N-acetylprocainamide ...
Anusha Balla, Han-Joo Maeng, Yu Chul Kim
exaly   +4 more sources

Effects of 1α,25-Dihydroxyvitamin D₃ on the Pharmacokinetics of Procainamide and Its Metabolite N-Acetylprocainamide, Organic Cation Transporter Substrates, in Rats with PBPK Modeling Approach [PDF]

Pharmaceutics, 2021
In this study, possible changes in the expression of rat organic cationic transporters (rOCTs) and rat multidrug and toxin extrusion proteins (rMATEs) following treatment with 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) were investigated.
Anusha Balla, Yoo-Seong Jeong, Hyo-Jung Kim, Yun-Jong Lee, Suk-Jae Chung, Yoon-Jee Chae, Han-Joo Maeng   +6 more
doaj   +2 more sources

Utility, promise, and limitations of liquid chromatography-mass spectrometry-based therapeutic drug monitoring in precision medicine. [PDF]

J Mass Spectrom, 2021
Abstract Therapeutic drug monitoring (TDM) is typically referred to as the measurement of the concentration of drugs in patient blood. Although in the past, TDM was restricted to drugs with a narrow therapeutic range in order to avoid drug toxicity, TDM has recently become a major tool for precision medicine being applied to many more drugs.
Gaspar VP, Ibrahim S, Zahedi RP, Borchers CH.   +3 more
europepmc   +2 more sources

Pediatric antiarrhythmics and toxicity: A clinical review. [PDF]

J Am Coll Emerg Physicians Open
Abstract Antiarrhythmic medications are fundamental in the acute and chronic management of pediatric arrhythmias. Particularly in the pediatric patient population, associated antiarrhythmic toxicities represent important potential adverse effects. Emergency medicine clinicians must be skilled in the detection, workup, and management of antiarrhythmic ...
Geanacopoulos AT, Zielonka B, Fox MT, Kerr S, Chambers KD, Przybylski R, Burns MM.   +6 more
europepmc   +2 more sources

Torsade de pointes induced by N-Acetylprocainamide

Journal of the American College of Cardiology, 1984
N-Acetylprocainamide (NAPA), a class III antiarrhythmic drug, caused torsade de pointes in a 72 year old woman who had this arrhythmia on two previous occasions while being treated with quinidine and disopyramide. Initial evaluation with an intravenous infusion of NAPA indicated a favorable antiarrhythmic response.
Chow, May J., Piergies, Antoni A., Bowsher, Dennis J., Murphy, John J., Kushner, William, Ruo, Tsuen Ih, Asada, Akira, Talano, James V., Atkinson, Arthur J.   +8 more
exaly   +3 more sources

N-Acetylprocainamide: An Active Metabolite of Procainamide

Experimental Biology and Medicine, 1974
SummaryN-Acetylprocainamide has been detected in the plasma samples of each of four patients receiving procainamide. The metabolite was identified from tlc data and its identity confirmed by gas chomatographic-mass spectroscopic analysis. The metabolite was also detected in the whole blood of Sprague-Dawley rats after administration of PA.
D E, Drayer, M M, Reidenberg, R W, Sevy
exaly   +3 more sources

Fluorometric Assay for N-Acetylprocainamide

Clinical Chemistry, 1975
Abstract We describe a simple, rapid fluorometric assay for separate quantitative analysis of procainamide and N-acetylprocainamide in mixtures. The effective linear range (fluorescence vs. concentration) in serum is 0.1 to 10.0 mg/liter, regardless of the ratio (by weight) of the two drugs from 1:10 to 10:1. Analytical recoveries by the
E, Matusik, T P, Gibson
openaire   +2 more sources

Kinetics of procainamide and N-acetylprocainamide in renal failure

Kidney International, 1977
Four normal subjects and four functionally anephric patients were given 6.5 mg/kg of body wt of procainamide hydrochloride i.v., and plasma concentrations of procainamide (PA) and its major active metabolite N-acetylprocainamide (NAPA) were measured. Two individuals in each group were fast isonicotinic acid hydrazide (INH) and PA acetylators.
Gibson, Thomas P., Atkinson, Arthur J., Matusik, Edward, Nelson, Lee D., Briggs, William A.   +4 more
openaire   +2 more sources

Circadian changes in procainamide and N-acetylprocainamide kinetics in the rat

Journal of Pharmacy and Pharmacology, 1985
AbstractThe aim of this study was to investigate the possible influence of the time of administration on procainamide and N-acetylprocainamide (NAPA) kinetics in the rat. A single 50 mg kg−1 i.p. dose of procainamide was given to Wistar AF SPF adult male rats maintained under controlled environmental conditions (LD: 06.00h-18.00h) at four different ...
B, Bruguerolle, G, Jadot
openaire   +2 more sources