Pharmacodynamics of intravenous procainamide as used during acute electropharmacologic testing [PDF]
, 1988 No previous studies have determined the pharmacodynamics of intravenous procainamide when administered in a dose of 15 mg/kg and at a rate of 50 mg/min, as is common practice during etectropharmacologic testing.
Annesley, Thomas M. +6 more
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A Correlation between Protein Function and Ligand Binding Profiles [PDF]
, 2011 We report that proteins with the same function bind the same set of small molecules from a standardized chemical library. This observation led to a quantifiable and rapidly adaptable method for protein functional analysis using experimentally-derived ...
Bokemper, Michael +4 more
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Target Molecules for Reactive Free Radical Metabolites of Aromatic Amines [PDF]
, 2011 Aromatic amines during peroxidase metabolism produce N-centered cationic radicals and phenyl radicals as reactive intermediates. The latter also induce protein oxidation. These findings are associated with drug induced agranulocytosis.
NARWALEY, MALYAJ
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Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus [PDF]
, 2002 Objective Inhibition of T cell DNA methylation causes autoreactivity in vitro and a lupus-like disease in vivo, suggesting that T cell DNA hypomethylation may contribute to autoimmunity. The hypomethylation effects are due, in part, to overexpression of
Arnett +32 more
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Molecular basis of the different effects of procainamide and N-acetylprocainamide on the maximum upstroke velocity and half-decay time of the cardiac action potential in guinea pig papillary muscle. [PDF]
Braz J Med Biol Res, 2023 Sigler W, Oliveira AC.
europepmc +1 more source
Pharmacogenetic studies on the drug-related lupus syndrome. differences in antinuclear antibody development and drug-induced DNA damage in rapid and slow acetylator animal models [PDF]
, 1981 Pharmacogenetic study of an inbred mouse model system derived from A/J (slow acetylator) and C57BL/6J (rapid acetylator) parental strains shows that spontaneous occurrence of antinuclear antibodies is associated with the slow acetylator phenotype ...
Brown +40 more
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, 1983 dissertationQuinidine is a naturally occurring substance used in the treatment of cardiac arrhythmias. It may be administered orally or parenterally to control both ventricular and supraventricular arrhythmias. Because of its low therapeutic index, it is
Gonzalez, Edgar R.
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A study of inter-individual variability in the Phase II metabolism of xenobiotics in human skin [PDF]
, 2018 YesUnderstanding skin metabolism is key to improve in vitro to in vivo extrapolations used to inform risk assessments of topically applied products. However, published literature is scarce and usually covers a limited and non-representative number of ...
Cubberley, R. +4 more
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Drug Therapy Problems And Quality Of Life In Patients With Chronic Kidney Disease [RM262. M289 2008 f rb]. [PDF]
, 2008 Masalah-masalah terapi drug (DTP) merupakan suatu cabaran penting kepada pengamal penjagaan kesihatan, ianya juga mempengaruhi morbiditi, mortaliti dan kualiti kehidupan pesakit (QoL).
Mahmoud, Mansour Adam
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