Results 11 to 20 of about 455 (155)

The role of antiarrhythmic drugs and stellate ganglion block in the acute management of electrical storm. [PDF]

Eur Heart J Suppl
Dusi V, Angelini F, Gravinese C, Frea S, De Ferrari GM.   +4 more
europepmc   +3 more sources

Anticholinergic activity and pharmacokinetic parameters of agent SS-68 with properties of class III antiarrhythmic drugs [PDF]

, 2016
It was shown that the indole derivate SS-68 (50 and 250 μg/kg intravenous) in acute experiments on cats with neurogenic atrial fibrillation (AF) has a dose-dependent antiarrhythmic action which is associated with the neurotropic influence of this ...
Bogus, S. K., Galenko-Yaroshevskii, P. A., Kulikov, A. L., Suzdalev, K. P., Vinakov, D. V.   +4 more
core   +2 more sources

Therapeutic and toxic blood concentrations of nearly 1,000 drugs and other xenobiotics [PDF]

, 2012
Introduction: In order to assess the significance of drug levels measured in intensive care medicine, clinical and forensic toxicology, as well as for therapeutic drug monitoring, it is essential that a comprehensive collection of data is readily ...
Andresen, Hilke, Iwersen-Bergmann, Stefanie, Schmoldt, Achim, Schulz, Martin   +3 more
core   +1 more source

A non-imaging high throughput approach to chemical library screening at the unmodified adenosine-A3 receptor in living cells [PDF]

, 2017
Recent advances in fluorescent ligand technology have enabled the study of G protein-coupled receptors in their native environment without the need for genetic modification such as addition of N-terminal fluorescent or bioluminescent tags.
Antonioli, Bain, Baker, Baker, Borea, Cao, Castro, Cohen, Cornelius, Crystal, Dalpiaz, Daly, Dionisotti, Fredholm, Fredholm, Gallo-Rodriguez, Gao, Gherbi, González-Fernández, Guo, Hara, Headrick, Hussain, Iturrioz, Jacobson, Jacobson, Ji, Joshaghani, Kecskes, Klotz, Klotz, Korb, Kozma, Kuder, Li, Little, May, Montinaro, Mulloy, Nakamura, Ohana, Ongini, Ranganathan, Ravani, Squarcialupi, Stoddart, Stoddart, Stoddart, Stoddart, Tomasch, Tosh, Vainio, van Galen, van Muijlwijk-Koezen, Vernall, Vernall, Wu, Yoshida, Young, Zwier   +59 more
core   +1 more source

A common polymorphism associated with antibiotic-induced cardiac arrhythmia [PDF]

, 2000
Drug-induced long QT syndrome (LQTS) is a prevalent disorder of uncertain etiology that predisposes to sudden death. KCNE2 encodes MinK-related peptide 1 (MiRP1), a subunit of the cardiac potassium channel I(Kr) that has been associated previously with ...
F. Sesti, G. W. Abbott, J. Wei, K. T. Murray, S. Saksena, P. J. Schwartz, S. G. Priori, D. M. Roden, A. L. George, S. A. N. Goldstein   +9 more
core   +3 more sources

Improving antibacterial prescribing safety in the management of COPD exacerbations:systematic review of observational and clinical studies on potential drug interactions associated with frequently prescribed antibacterials among COPD patients [PDF]

, 2019
BACKGROUND: Guidelines advise the use of antibacterials (ABs) in the management of COPD exacerbations. COPD patients often have multiple comorbidities, such as diabetes mellitus and cardiac diseases, leading to polypharmacy.
Alffenaar, Jan-Willem C., Bahar, Muh. Akbar, Borgsteede, Sander D., Hak, Eelko, Jansen, Anouk M. E., Kocks, Janwillem W. H., Wang, Yuanyuan, Wilffert, Bob   +7 more
core   +1 more source

N-acetylprocainamide is a less potent inducer of t cell autoreactivity than procainamide [PDF]

, 1988
We have reported that an inhibitor of DNA methylation, 5-azacytidine, makes cloned, antigen-specific CD4 + T cells autoreactive, and that procainamide and hydralazine mimic this effect. Those results suggested that procainamide and hydralazine may induce
Bell, Blomgren, Cornacchia, Dubroff, Dubroff, Jones, Jones, Kluger, Lieberman, Ludden, Maybaum, Nickerson, Reidenberg, Richardson, Richardson, Roden, Rolink, Snati, Sonnhag, Stec, Taylor, Thomas, Woodcock   +22 more
core   +1 more source

Incorporating DNA Methyltransferase Inhibitors (DNMTis) in the Treatment of Genitourinary Malignancies: A Systematic Review. [PDF]

Target Oncol, 2018
Inhibition of DNA methyltransferases (DNMTs) has emerged as a novel treatment strategy in solid tumors. Aberrant hypermethylation in promoters of critical tumor suppressor genes is the basis for the idea that treatment with hypomethylating agents may ...
Chovanec M, Taza F, Kalra M, Hahn N, Nephew KP, Spinella MJ, Albany C.   +6 more
europepmc   +3 more sources

Mechanisms of drug-induced lupus. IV. Comparison of procainamide and hydralazine with analogs in vitro and in vivo [PDF]

, 1997
Objective . T cells treated with DNA methylation inhibitors overexpress lymphocyte function-associated antigen 1 (LFA-1), which results in autoreactivity, and the autoreactive cells cause a lupus-like disease in vivo, suggesting a mechanism by which some
Chang, Sandra, Hemati, Nahid, Johnson, Kent J., Richardson, Bruce C., Yung, Raymond L.   +4 more
core   +1 more source

Electrochemistry-on-chip for on-line conversions in drug metabolism studies [PDF]

, 2010
We have designed an integrated 3-electrode electrochemical cell on-chip with high analyte conversion rates for use in drug metabolism studies. The electrochemical cell contains platinum working and counter electrodes and an iridium oxide pseudo-reference
Baumann, A., Karst, U., Odijk, M., Olthuis, W., van den Berg, A.   +4 more
core   +2 more sources