Results 11 to 20 of about 13,471,027 (144)

Kinetics of procainamide and N-acetylprocainamide in renal failure [PDF]

Kidney International, 1977
Four normal subjects and four functionally anephric patients were given 6.5 mg/kg of body wt of procainamide hydrochloride i.v., and plasma concentrations of procainamide (PA) and its major active metabolite N-acetylprocainamide (NAPA) were measured. Two individuals in each group were fast isonicotinic acid hydrazide (INH) and PA acetylators.
Gibson, Thomas P., Atkinson, Arthur J., Matusik, Edward, Nelson, Lee D., Briggs, William A.   +4 more
openaire   +3 more sources

Torsade de pointes induced by N-Acetylprocainamide [PDF]

Journal of the American College of Cardiology, 1984
N-Acetylprocainamide (NAPA), a class III antiarrhythmic drug, caused torsade de pointes in a 72 year old woman who had this arrhythmia on two previous occasions while being treated with quinidine and disopyramide. Initial evaluation with an intravenous infusion of NAPA indicated a favorable antiarrhythmic response.
Chow, May J., Piergies, Antoni A., Bowsher, Dennis J., Murphy, John J., Kushner, William, Ruo, Tsuen Ih, Asada, Akira, Talano, James V., Atkinson, Arthur J.   +8 more
openaire   +3 more sources

Circadian changes in procainamide and N-acetylprocainamide kinetics in the rat

Journal of Pharmacy and Pharmacology, 1985
AbstractThe aim of this study was to investigate the possible influence of the time of administration on procainamide and N-acetylprocainamide (NAPA) kinetics in the rat. A single 50 mg kg−1 i.p. dose of procainamide was given to Wistar AF SPF adult male rats maintained under controlled environmental conditions (LD: 06.00h-18.00h) at four different ...
B, Bruguerolle, G, Jadot
openaire   +3 more sources

Kinetics of N-acetylprocainamide deacetylation

Clinical Pharmacology and Therapeutics, 1980
The kinetics of N-acetylprocainamide (NAPA) deacetylation to procainamide (PA) were determined in a normal subject using NAPA-13C, labeled in the acetyl group. The deacetylation clearance of NAPA (ClD) was found to be 6.5 ml/min whereas total NAPA elimination clearance was 231 ml/min, so that 2.8% of the administered NAPA-13C was metabolized by ...
G P, Stec, T I, Ruo, J P, Thenot, A J, Atkinson, Y, Morita, J J, Lertora   +5 more
openaire   +3 more sources

Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances. [PDF]

Antimicrob Agents Chemother, 2005
Ten healthy adults participated in a randomized, crossover drug interaction study testing procainamide only, procainamide plus levofloxacin, and procainamide plus ciprofloxacin.
Bauer LA, Black DJ, Lill JS, Garrison J, Raisys VA, Hooton TM.   +5 more
europepmc   +2 more sources

Fluorometric Assay for N-Acetylprocainamide

Clinical Chemistry, 1975
Abstract We describe a simple, rapid fluorometric assay for separate quantitative analysis of procainamide and N-acetylprocainamide in mixtures. The effective linear range (fluorescence vs. concentration) in serum is 0.1 to 10.0 mg/liter, regardless of the ratio (by weight) of the two drugs from 1:10 to 10:1. Analytical recoveries by the
E, Matusik, T P, Gibson
openaire   +2 more sources

N-acetylprocainamide is a less potent inducer of t cell autoreactivity than procainamide [PDF]

, 1988
We have reported that an inhibitor of DNA methylation, 5-azacytidine, makes cloned, antigen-specific CD4 + T cells autoreactive, and that procainamide and hydralazine mimic this effect. Those results suggested that procainamide and hydralazine may induce
Richardson, Bruce C., Maybaum, Jonathan, Hanash, Samir M., Golbus, Joseph, Strahler, John R., Cornacchia, Elizabeth   +5 more
core   +1 more source

N-Acetylprocainamide: An Active Metabolite of Procainamide

Experimental Biology and Medicine, 1974
SummaryN-Acetylprocainamide has been detected in the plasma samples of each of four patients receiving procainamide. The metabolite was identified from tlc data and its identity confirmed by gas chomatographic-mass spectroscopic analysis. The metabolite was also detected in the whole blood of Sprague-Dawley rats after administration of PA.
D E, Drayer, M M, Reidenberg, R W, Sevy
openaire   +2 more sources

Effects of N-acetylprocainamide on experimental atrial flutter and atrial electrophysiologic properties in conscious dogs with sterile pericarditis: Comparison with the effects of quinidine [PDF]

, 1987
N-acetylprocainamide (NAPA) is said to have class HI antiarrhythmic drug properties. The effects of NAPA (25 mg/kg intravenously) on sustained, stable, reentrant atrial flutter induced in 12 conscious dogs using a sterile pericarditis model were studied ...
Okumura, Ken, Waldo, Albert L.
core   +1 more source

Rate-Dependent Effects of Lidocaine on His-Purkinje Conduction in the Intact Neonatal Heart - Characterization and Amplification by N- Acetylprocainamide

, 1991
According to mathematical models of antiarrhythmic drug-receptor interactions, lidocaine binds preferentially to the sodium channel when the membrane is depolarized (i.e., the \u27inactivated\u27 channel state).
Clarkson, C. W., Dise, T. L., Stolfi, Adrienne, Pickoff, Arthur S.   +3 more
core   +2 more sources