Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants
The Journal of General Physiology, 2017 Local anesthetics, antiarrhythmics, and anticonvulsants include both charged and electroneutral compounds that block voltage-gated sodium channels. Prior studies have revealed a common drug-binding region within the pore, but details about the binding ...
D. Tikhonov, B. Zhorov
semanticscholar +1 more source
Evaluation of a pharmacist-led medication assessment used to identify prevalence of and associations with polypharmacy and potentially inappropriate medication use among ambulatory senior adults with cancer. [PDF]
, 2015 PURPOSE: The use of multiple and/or inappropriate medications in seniors is a significant public health problem, and cancer treatment escalates its prevalence and complexity.
Andrel-Sendecki, Jocelyn +4 more
core +2 more sources
Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation.
Cochrane Database of Systematic Reviews, 2019 BACKGROUND Atrial fibrillation is the most frequent sustained arrhythmia. Atrial fibrillation often recurs after restoration of normal sinus rhythm. Antiarrhythmic drugs have been widely used to prevent recurrence.
Lucie Valembois +5 more
semanticscholar +1 more source
Atrial fibrillation pharmacotherapy after hospital discharge between 1995 and 2004: a shift towards beta-blockers. [PDF]
, 2008 Udgivelsesdato: 2008-AprAIMS: To study evolvement in pharmacotherapy of atrial fibrillation from 1995 to 2004. METHODS AND RESULTS: All Danish patients were discharged following first-time atrial fibrillation and their pharmacotherapy was identified by ...
Abildstrom, Steen Z +12 more
core +1 more source
Experimental Physiology, 2019 What is the central question of this study? Are modifications in the restitution of ventricular action potential duration induced by antiarrhythmic drugs the same when assessed with premature extrastimulus application at variable coupling intervals (the ...
O. Osadchii
semanticscholar +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Differential Free Intracellular Calcium Release by Class II Antiarrhythmics in Cancer Cell Lines
Journal of Pharmacology and Experimental Therapeutics, 2019 Class II antiarrhythmics or β-blockers are antisympathetic nervous system agents that act by blocking β-adrenoceptors. Despite their common clinical use, little is known about the effects of β-blockers on free intracellular calcium (Ca2+i), an important ...
Marta Reyes-Corral +5 more
semanticscholar +1 more source
Class III Antiarrhythmics and Periprocedural Torsades de Pointes
JACC: Case Reports, 2023 This case series describes 2 women on prolonged therapy with class III antiarrhythmics who developed torsades de pointes polymorphic ventricular tachycardia in the setting of catheter ablation for atrial fibrillation as a result of QTc prolonging factors.
Cristina M. Font, MD +1 more
doaj +1 more source
Science Advances, 2017 Antiarrhythmics and proarrhythmics targeting ERG K+ channels act oppositely to tune parkinsonian brain rhythms and motor behaviors. ERG K+ channels have long been known to play a crucial role in shaping cardiac action potentials and, thus, appropriate ...
Chen-Syuan Huang +4 more
semanticscholar +1 more source
Tratamiento antiarrítmico actual de la fibrilación auricular no valvular en España: datos del Registro FANTASIIA [PDF]
, 2015 [Abstract] Introduction and objectives. Recently, there have been many developments in the management of nonvalvular atrial fibrillation, antiarrhythmic and anticoagulant therapy, and nonpharmacological treatment, but these developments are not applied ...
Anguita Sanchez, Manuel +10 more
core +2 more sources