Results 111 to 120 of about 577,991 (307)

New strategies for multifunctional antibacterial materials [Elektronisk resurs]

, 2023
Healthcare-associated infections (HAI) are responsible for significant financial and human costs in healthcare systems. Therefore, a substantial amount of research has been devoted to developing biopolymer-based strategies that prevent bacterial ...
Ruan, Hengzhi,
core  

Discovery of pyridomycin derivatives as InhA inhibitors from actinomycetes through molecular networking and an In-House tandem mass library

Natural Products and Bioprospecting
A screen of ~ 4000 actinomycetes strains identified Streptomyces sp. W3009 as a producer of the antituberculosis agent pyridomycin. Using a mass spectrometry-based metabolomics approach coupled with molecular networking, we identified seven pyridomycin ...
Byeongsan Lee, Gwi Ja Hwang, Jun-Pil Jang, Beomcheol Park, Juhee Won, Sun Young Kim, Minjeong Woo, Connor Wood, Bang Yeon Hwang, Jae-Hyuk Jang, Young-Soo Hong   +10 more
doaj   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics‐Based Optimization with Limited Activity Data

Advanced Science, EarlyView.
Using a minimal set of experimentally labeled antimicrobial and non‐antimicrobial peptides, we reconstruct the effective lipid composition of a pathogenic membrane ‐demonstrated at the example of bacterial membranes‐ through a physics‐based evolutionary molecular dynamics (Evo‐MD) approach. Optimization based on peptide insertion reveals broad‐spectrum
Maximilian Krebs, Herre Jelger Risselada
wiley   +1 more source

Identification of covalent inhibitors of Staphylococcus aureus serine hydrolases important for virulence and biofilm formation

Nature Communications
Staphylococcus aureus is a leading cause of bacteria-associated mortality worldwide. New tools are needed to both image and treat this pathogen. We previously identified a group of S.
Tulsi Upadhyay, Emily C. Woods, Stephen Dela Ahator, Kjersti Julin, Franco F. Faucher, Md Jalal Uddin, Marijn J. Hollander, Nichole J. Pedowitz, Daniel Abegg, Isabella Hammond, Ifeanyichukwu E. Eke, Sijie Wang, Shiyu Chen, John M. Bennett, Jeyun Jo, Christian S. Lentz, Alexander Adibekian, Matthias Fellner, Matthew Bogyo   +18 more
doaj   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

In vitro antibacterial and antifungal evaluation of some benzophenone analogues [PDF]

, 2013
Antibacterial and antifungal agents are widely used in the management of infectious disease but most of them have developed resistance to micro-organism.
Khanum, S. A., Al-Ghorbani, M., Lakshmi Ranganatha, V., Prashanth, T., Bushra Begum, A.   +4 more
core  

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Advanced Science, EarlyView.
A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li   +10 more
wiley   +1 more source

Metallic nanoparticles: antibacterial activity and ecotoxicity

, 2018
Healthcare is considered one of the most significant domains of nano-biotechnology. The use of metal nanostructures paves the way for numerous applications in this field such as antibacterial paints, antibacterial patches or even antibacterial films. The
E. Galdiero, S. Galdiero, A. Falanga, G. Morelli, S. Galdiero., L. Lombardi, A. Mercurio, M. Leone   +7 more
core  

F‐Type Pyocin Versus Phage λ Tail: Conserved Hub, Divergent Fibers

Advanced Science, EarlyView.
Near‐atomic cryo‐EM structures of a Gram‐negative F‐type pyocin reveal a conserved tail tip architecture shared with bacteriophage λ together with a previously unrecognized side‐fiber attachment mode. These findings provide new insight into tailocin assembly and host recognition and establish a structural framework for engineering precision ...
Zhiwei Gu, Yufan Xie, Lanxin Wang, Luyan Ma, Xiaofei Ge, Jiawei Wang   +5 more
wiley   +1 more source