Results 121 to 130 of about 498,913 (308)

Identification of covalent inhibitors of Staphylococcus aureus serine hydrolases important for virulence and biofilm formation

Nature Communications
Staphylococcus aureus is a leading cause of bacteria-associated mortality worldwide. New tools are needed to both image and treat this pathogen. We previously identified a group of S.
Tulsi Upadhyay, Emily C. Woods, Stephen Dela Ahator, Kjersti Julin, Franco F. Faucher, Md Jalal Uddin, Marijn J. Hollander, Nichole J. Pedowitz, Daniel Abegg, Isabella Hammond, Ifeanyichukwu E. Eke, Sijie Wang, Shiyu Chen, John M. Bennett, Jeyun Jo, Christian S. Lentz, Alexander Adibekian, Matthias Fellner, Matthew Bogyo   +18 more
doaj   +1 more source

Stress History Establishes a Transient Tolerant State That Shapes Antibiotic Survival Upon Resuscitation

Advanced Science, EarlyView.
High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott, Georgeos Hardo, Ruizhe Li, Jack Bradley, Ashraf Zarkan, Somenath Bakshi   +5 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Economic Burden of Uncontrolled COPD Under Triple Therapy: A Population-Based Study

International Journal of COPD
Nicolas Molinari,1 Nicolas Roche,2 Anne-Lise Vataire,3 Stanislas Perrier,3 Nicolas Pagès,4 Arnaud Panes,4 Aurélie Schmidt,4 Arnaud Bourdin,5,6 Laurence Watier7 1IDESP, INSERM, PreMEdical INRIA, Univ Montpellier, CHU Montpellier, Montpellier, France ...
Molinari N, Roche N, Vataire AL, Perrier S, Pagès N, Panes A, Schmidt A, Bourdin A, Watier L   +8 more
doaj  

Reducing Peptidoglycan Crosslinking by Chemical Modulator Reverts β‐lactam Resistance in Methicillin‐Resistant Staphylococcus aureus

Advanced Science
Small molecule can be utilized to restore the effectiveness of existing major classes of antibiotics against antibiotic‐resistant bacteria. In this study, it is demonstrated that celastrol, a natural compound, can modify the bacterial cell wall and ...
Ji‐Hoon Kim, Yunmi Lee, Inseo Kim, JuOae Chang, Subin Hong, Na Kyung Lee, David Shum, Seongeun Baek, Wooseong Kim, Soojin Jang, Wonsik Lee   +10 more
doaj   +1 more source

Quantitative determination and antibacterial properties of TiO2 nanoparticle-doped glass ionomer cement: an in vitro study

European Oral Research
Purpose: The aim of the present study is to determine the amount of titanium ions released into the artificial salivary medium by modified glass ionomer cement (GIC) doped with 3% and 5% (w/w) titanium dioxide nanoparticles (TiO2-NPs), and to evaluate ...
Tivanani V D Mahendra, Tavva Santhosh Rahul, Santosh Venkata Ramesh Konathala, P Swetha, V Sai Sai Keerthi, Vyshnavi M   +5 more
doaj   +1 more source

Highly Flexible and Conformable ZnO/FeGa Magnetoelectric Heterostructures for Skin wound Healing

Advanced Science, EarlyView.
The magnetic field‐induced electric field generated by a highly flexile ZnO(piezoelectric)/FeGa(magnetostrictive) magnetoelectric heterostructure embedded in the low Young's modulus elastomer PDMS has been used to stimulate the wound healing processes.
Filippos Perdikos, Laia Bagur, Cristina Vaca, Aritz Lafuente, Joaquin Llacer‐Wintle, Bojan Ambrožič, Christina Stefani, Minsoo Kim, Goran Dražić, Darja Lisjak, Jordi Sort, Xiang‐Zhong Chen, Maria Jose Esplandiu, Salvador Pané, Carme Nogués, Josep Nogués, Andreu Blanquer, Borja Sepúlveda   +17 more
wiley   +1 more source

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

Nanomaterials for alternative antibacterial therapy [PDF]

, 2017
Hassan A Hemeg Department of Medical Laboratories Technology, Faculty of Applied Medical Sciences, Taibah University, Medina, Kingdom of Saudi Arabia Abstract: Despite an array of cogent antibiotics, bacterial infections, notably those produced by ...
Hemeg HA
core  

Polychip‐A High‐Throughput Droplet Microfluidics Platform for Interrogating Microbial Interactions

Advanced Science, EarlyView.
Polychip, a fully integrated droplet microfluidics platform, enables high‐throughput, single‐cell resolution screening of polymicrobial interactions. By seamlessly combining six automated microfluidics operations on a single chip, the system accelerates antimicrobial discovery by 11 to 14 times compared to traditional robotic methods.
Jeong Jae Han, Adrian Ryan Guzman, Aifen Zhou, Han Zhang, Rohit Gupte, Haemin Jung, Kaylee Delgado, Sini Skariah, Ali Sultan, Arul Jayaraman, Paul de Figueiredo, Arum Han   +11 more
wiley   +1 more source