Results 241 to 250 of about 3,637,165 (381)

Kinsenoside‐Loaded Microneedle Accelerates Diabetic Wound Healing by Reprogramming Macrophage Metabolism via Inhibiting IRE1α/XBP1 Signaling Axis

open access: yesAdvanced Science, EarlyView.
Gut metabolite trimethylamine N‐oxide accumulates in the diabetic wound area to amplify macrophage inflammation via enhancing glycolysis activities. Kinsenoside induces macrophage repolarization from M1 to M2 phenotype through inhibiting IRE1α/XBP1 pathway, followed by HIF‐1α‐glycolysis axis repression and mitophagy‐oxidative phosphorylation axis ...
Li Lu   +13 more
wiley   +1 more source

AuCu@CuO2 Aerogels with H2O2/O2 Self‐Supplying and Quadruple Enzyme‐Like Activity for MRSA‐Infected Diabetic Wound Management

open access: yesAdvanced Science, EarlyView.
The AuCu@CuO2 aerogels demonstrate favorable photothermal properties, four types of enzyme‐like activities, and H2O2/O2 self‐supplying to modulate the complex microenvironment of MRSA‐infected diabetic wounds. The results indicate that the AuCu@CuO2 aerogel can be activated by the microenvironment of diabetic wound infection, alleviating inflammation ...
Xiaofeng Tan   +10 more
wiley   +1 more source

Photocatalytic Bilateral Disulfuration of Thioethers Toward α‐Sulfide Disulfides With Antibacterial Activity

open access: yesAdvanced Science, EarlyView.
This study introduces a mild photocatalytic strategy for synthesizing tunable α‐sulfide disulfides from readily available sulfides and bilateral disulfurating reagents. The method demonstrates a broad substrate scope across aromatic and aliphatic sulfides, with products exhibiting versatile reactivity in diverse electrophilic transformations and ...
Qingqiang Tian   +4 more
wiley   +1 more source

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