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The Neurotoxicity of Antibacterial Agents
Annals of Internal Medicine, 1984Commonly used antibacterial agents may be associated with various neurotoxic reactions. Central nervous system toxicities include seizure disorders, encephalopathy, bulging fontanelles, and neuropsychiatric symptoms. These abnormalities have been associated with the use of the penicillins, cephalosporins, sulfonamides, tetracyclines, chloramphenicol ...
Glenn R. Hodges, Sharon R. Snavely
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Antibacterial Agents in the Elderly
Infectious Disease Clinics of North America, 2009Older patients disproportionately suffer the burden of infection in the community and in health care facilities. The rational approach to antimicrobial therapy for older patients with infection requires an appreciation and understanding of the complex immunologic, epidemiologic, pharmacologic, and microbiologic factors that influence the manifestations
Emily Landon Mawdsley +2 more
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Current Medicinal Chemistry, 2003
Hard drugs have been defined as drugs that are biologically active and non-metabolizable in vivo. Soft drugs are defined as drugs, which are characterized by predictable and controllable in vivo destruction (i.e. metabolism) to form non-toxic products after they have achieved their therapeutic role.
Thorsteinn Loftsson +2 more
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Hard drugs have been defined as drugs that are biologically active and non-metabolizable in vivo. Soft drugs are defined as drugs, which are characterized by predictable and controllable in vivo destruction (i.e. metabolism) to form non-toxic products after they have achieved their therapeutic role.
Thorsteinn Loftsson +2 more
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Antibacterial Agents in Pediatrics
Infectious Disease Clinics of North America, 2009Antibiotics are among the most frequently used drugs in children. Although antibacterials have been available for decades, many agents have not been studied to assess their safety and efficacy in the pediatric population. This article describes the pharmacologic characteristics and therapeutic use of the most commonly prescribed antibacterials for ...
Terrence L. Stull, Susana Chavez-Bueno
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Silver as antibacterial agent: ion, nanoparticle, and metal.
Angewandte Chemie, 2013The antibacterial action of silver is utilized in numerous consumer products and medical devices. Metallic silver, silver salts, and also silver nanoparticles are used for this purpose.
S. Chernousova, M. Epple
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ANTIBACTERIAL AGENTS IN PEDIATRICS
Infectious Disease Clinics of North America, 2000From low birth weight infants to adolescents, physiologic and developmental differences underlie the marked differences in pharmacokinetics and pharmacodynamics of antibacterial agents. Certain diseases, such as cystic fibrosis, also can alter these parameters.
V H, San Joaquin, T L, Stull
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Resistance to Antibacterial Agents
1995There are three major mechanisms whereby bacteria initially susceptible to an antimicrobial agent may acquire the ability to resist the effects of this agent. These include prevention of intracellular drug accumulation, alteration in the target of the drug, and production of a drug-inactivating enzyme.
W. Eugene SandersJr. +1 more
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ANTIBACTERIAL AGENTS IN PEDIATRICS
Infectious Disease Clinics of North America, 1995The utility of various antibacterial agents for therapy of infectious diseases in children is determined by the unique pharmacokinetics and potential toxicity in children. The important age-related principle of pharmacokinetics is reviewed in the first section of this article; the second section focuses on specific therapeutic agents and their use in ...
J J, LiPuma, T L, Stull
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Mechanistic Insight into the Light-Irradiated Carbon Capsules as an Antibacterial Agent.
ACS Applied Materials and Interfaces, 2018Infections caused by bacteria are a growing global challenge for public health as bacteria develop resistance, which will cause the failure of anti-infective treatment eventually.
Qiuwen Wu +6 more
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Pathogens Resistant to Antibacterial Agents
Medical Clinics of North America, 2009Resistance to antimicrobial drugs is increasing at an alarming rate among both gram-positive and gram-negative bacteria. Traditionally, bacteria resistant to multiple antimicrobial agents have been restricted to the nosocomial environment. A disturbing trend has been the recent emergence and spread of resistant pathogens in nursing homes, in the ...
Luke F. Chen +2 more
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