Results 171 to 180 of about 1,859,987 (291)

Exploring chemical space for iridium(iii) complexes: a direct-to-biology (D2B) approach to identifying anticancer and antibacterial agents. [PDF]

Chem Sci
Kench T, Wang Y, Seefeldt J, Majid A, Man-Hei Yip A, Shum J, Terrones GG, Antar Y, Holbling BV, Kam-Wing Lo K, Metzler-Nolte N, Kulik HJ, Vilar R.   +12 more
europepmc   +1 more source

Smartphone‐Guided Visible Light Modulation of RSNOs for Antimicrobial Activity via Controlled Nitric Oxide Release

Advanced Science, EarlyView.
A light‐activated catheter insert combines antimicrobial blue light with nitric oxide release to generate complementary oxidative and nitrosative stress, producing potent broad‐spectrum antimicrobial activity. The approach achieves greater than 4‐log reductions in bacterial and fungal viability and significantly reduces Staphylococcus aureus ...
Alexander Bruckmann, Adam Brooks Goodman, Myddelton C. Parker, Mark Garren, Ji Eun Park, Chad Schmiedt, Hitesh Handa, Elizabeth J. Brisbois   +7 more
wiley   +1 more source

Six Essential Oils as Potential Antibacterial Agents Against Extensively Drug-Resistant (XDR) Gram-Negative Clinical Isolates. [PDF]

Antibiotics (Basel)
Bǎdescu-Chircea B, Liga S, Licker M, Dugăeşescu D, Popa MD, Piluţ CN, Vulpie S, Buda VO, Muntean D.   +8 more
europepmc   +1 more source

Current landscape in the discovery of novel antibacterial agents

Background: Standard treatments against bacterial infections are becoming ineffective due to the rise of antibacterial resistance worldwide. Classical approaches to develop new antibacterial agents are not sufficient to fulfil the current pipeline ...
Moreno Morales, Javier, Vila Estapé, Jordi, Ballesté-Delpierre, Clara   +2 more
core  

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

Discovery of guanidinium salt incorporating cinnamic acid skeleton as new antibacterial agents against Gram-positive bacteria. [PDF]

Front Microbiol
Zhou F, Zhao P, Liu M, Li H, Wang Y, Liang L.   +5 more
europepmc   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Synthesis and Biological Evaluation of New Quinazolin-4(3H)-One-Coumarin Hybrids Designed as Anticancer and Antibacterial Agents. [PDF]

Int J Mol Sci
Paramonova MP, Novikov MS, Sokhraneva VA, Zhivotova IS, Kezin VA, Zenov MA, Petrushanko IY, Novikova ON, Gorshenin AV, Velikorodnaya YI, Isakova EB, Shchekotikhin AE, Kochetkov SN, Matyugina ES, Khandazhinskaya AL.   +14 more
europepmc   +1 more source

Developing Metal–Polyphenol Network‐Based Single‐Protein Particle Encapsulation System for Sustained Release of Whey Protein to Mitigate Sarcopenia

Advanced Science, EarlyView.
Sarcopenia has emerged as a major health challenge in the aging population. Developing a sustained‐release system for whey protein may enhance its effectiveness in mitigating sarcopenia. Herein, a novel “single‐protein particle encapsulation” (SPPE) system is developed to protect whey protein and control its release.
Yafei Zhang, Yuning Zhang, Yongjian Ai, Yao Lu, Heng Quan, Zhen Zhang, Yuqi Wang, Yujia Luo, Xiaoxu Zhang, Yingying Lin, Sijia Song, Huiyuan Guo   +11 more
wiley   +1 more source

Design and Synthesis of Novel Morpholine-Derived Nitrogen-Rich Scaffolds as Multifunctional Anticancer and Antibacterial Agents: Biological Evaluation and Computational Studies. [PDF]

Pharmaceutics
El-Hema HS, Adel E, El-Dougdoug WI, Wasfy AAF, El-Sayed AF, Nossier ES, Hussein MF, Binsuwaidan R, Saleh A, Abdel-Rahmanh AA.   +9 more
europepmc   +1 more source