Results 231 to 240 of about 1,859,987 (291)
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Current Medicinal Chemistry, 2003
Hard drugs have been defined as drugs that are biologically active and non-metabolizable in vivo. Soft drugs are defined as drugs, which are characterized by predictable and controllable in vivo destruction (i.e. metabolism) to form non-toxic products after they have achieved their therapeutic role.
T, Thorsteinsson, T, Loftsson, M, Masson
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Hard drugs have been defined as drugs that are biologically active and non-metabolizable in vivo. Soft drugs are defined as drugs, which are characterized by predictable and controllable in vivo destruction (i.e. metabolism) to form non-toxic products after they have achieved their therapeutic role.
T, Thorsteinsson, T, Loftsson, M, Masson
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Infectious Disease Clinics of North America, 1995
Topical antibacterial agents offer a useful alternative to systemic agents in certain circumstances. Uses include prophylaxis of infection for burns, traumatic wounds, and intravascular catheters, as well as eradication of S. aureus nasal carriage and treatment of primary and secondary pyodermas.
E T, Kaye, K M, Kaye
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Topical antibacterial agents offer a useful alternative to systemic agents in certain circumstances. Uses include prophylaxis of infection for burns, traumatic wounds, and intravascular catheters, as well as eradication of S. aureus nasal carriage and treatment of primary and secondary pyodermas.
E T, Kaye, K M, Kaye
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Antibacterial Agents in the Elderly
Infectious Disease Clinics of North America, 2009Older patients disproportionately suffer the burden of infection in the community and in health care facilities. The rational approach to antimicrobial therapy for older patients with infection requires an appreciation and understanding of the complex immunologic, epidemiologic, pharmacologic, and microbiologic factors that influence the manifestations
Stephen, Weber +2 more
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The Neurotoxicity of Antibacterial Agents
Annals of Internal Medicine, 1984Commonly used antibacterial agents may be associated with various neurotoxic reactions. Central nervous system toxicities include seizure disorders, encephalopathy, bulging fontanelles, and neuropsychiatric symptoms. These abnormalities have been associated with the use of the penicillins, cephalosporins, sulfonamides, tetracyclines, chloramphenicol ...
S R, Snavely, G R, Hodges
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ANTIBACTERIAL AGENTS IN PEDIATRICS
Infectious Disease Clinics of North America, 2000From low birth weight infants to adolescents, physiologic and developmental differences underlie the marked differences in pharmacokinetics and pharmacodynamics of antibacterial agents. Certain diseases, such as cystic fibrosis, also can alter these parameters.
V H, San Joaquin, T L, Stull
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Antibacterial agents in pediatrics
Infectious Disease Clinics of North America, 2004Antibiotics are among the most widely prescribed therapeutic agents in children. Several new trends in antibiotic usage for pediatric care have emerged. New mechanisms of antibacterial resistance have required a broader repertoire of antibiotic usage, including new agents directed at multidrug resistance.
Karen L, Bowlware, Terrence, Stull
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Resistance to Antibacterial Agents
1995There are three major mechanisms whereby bacteria initially susceptible to an antimicrobial agent may acquire the ability to resist the effects of this agent. These include prevention of intracellular drug accumulation, alteration in the target of the drug, and production of a drug-inactivating enzyme.
C C, Sanders, W E, Sanders
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Antibacterial Agents in Pediatrics
Infectious Disease Clinics of North America, 2009Antibiotics are among the most frequently used drugs in children. Although antibacterials have been available for decades, many agents have not been studied to assess their safety and efficacy in the pediatric population. This article describes the pharmacologic characteristics and therapeutic use of the most commonly prescribed antibacterials for ...
Susana, Chavez-Bueno, Terrence L, Stull
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Infectious Disease Clinics of North America, 2000
Topical antibacterial agents occupy an important niche of antimicrobial therapy for both inpatients and outpatients. These agents, including antiseptic and antibiotic preparations, are used for prophylaxis and treatment of infection. Prophylactic uses include application for traumatic and surgical wounds, burns, intravascular catheters, and eradication
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Topical antibacterial agents occupy an important niche of antimicrobial therapy for both inpatients and outpatients. These agents, including antiseptic and antibiotic preparations, are used for prophylaxis and treatment of infection. Prophylactic uses include application for traumatic and surgical wounds, burns, intravascular catheters, and eradication
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ANTIBACTERIAL AGENTS IN PEDIATRICS
Infectious Disease Clinics of North America, 1995The utility of various antibacterial agents for therapy of infectious diseases in children is determined by the unique pharmacokinetics and potential toxicity in children. The important age-related principle of pharmacokinetics is reviewed in the first section of this article; the second section focuses on specific therapeutic agents and their use in ...
J J, LiPuma, T L, Stull
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