, 2012 By studying the literature about Tetracyclines (TCs), it becomes clearly evident that TCs are very dynamic molecules. In some cases, their structure-activity-relationship (SAR) are known, especially against bacteria, while against other targets, they are
Bortolotto +17 more
core +2 more sources
Antimicrobial and anti-inflammatory activity of chitosan-alginate nanoparticles: a targeted therapy for cutaneous pathogens. [PDF]
, 2013 Advances in nanotechnology have demonstrated potential application of nanoparticles (NPs) for effective and targeted drug delivery. Here we investigated the antimicrobial and immunological properties and the feasibility of using NPs to deliver ...
Blecher-Paz, Karin +10 more
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Employing Copper-Based Nanomaterials to Combat Multi-Drug-Resistant Bacteria
MicroorganismsThe rise of multi-drug-resistant (MDR) bacteria poses a severe global threat to public health, necessitating the development of innovative therapeutic strategies to overcome these challenges.
Yujie Zhai +3 more
doaj +1 more source
The review of pathogenic mechanism of Aeromonas hydrophila and action of tetracycline against it in aquatic animals [PDF]
بومشناسی آبزیان, 2017 Aeromonas hydrophila is one of common bacterial disease in aquatic animals and its outbreak cause to decrease of aquatic production. Aeromonas disease is due to a protein toxin, aerolysin that exported by Aeromonas hydrophila.
Somayeh Pakravan, Arash Akbarzadeh
doaj
Antibacterial Activities and Mechanism of Action of Acetone Extracts From Rabdosia Rubescens [PDF]
, 2015 The antibacterial activities and mechanism of action of acetone extracts from R. rubescens were reported in this paper. The results showed that 80% acetone extracts had both the highest contents of total phenolics and flavonoids.
Cheng, L. P. (Li), Hu, Q. P. (Qing)
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Research Progress on the Antibacterial Activity of Natural Flavonoids
AntibioticsThe use of antibiotics has greatly improved the treatment of bacterial infections; however, its abuse and misuse has led to a rapid rise in multidrug-resistant (MDR) bacteria.
Zhijin Zhang +10 more
doaj +1 more source
The potential of Symbiont Ba cteria in Melo melo Gastropod found in Pekalongan Waters as a source of MDR antibacterial active compound [PDF]
, 2016 The increasing resistance of many pathogenic microorganisms against antibiotics compounds creates an alarming issue in medical world. This concern has created research opportunities in new antibiotics compounds as alternative options.
Maulidi, Zuhdi +2 more
core
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source