Results 41 to 50 of about 15,512 (295)
Molecules, 2017 Aminodehalogenation of 3-chloropyrazine-2-carboxamide with variously substituted benzylamines yielded a series of fifteen 3-benzylaminopyrazine-2-carboxamides. Four compounds possessed in vitro whole cell activity against Mycobacterium tuberculosis H37Rv
Ondrej Jandourek +8 more
doaj +1 more source
Quinolones: Mechanism, Lethality and Their Contributions to Antibiotic Resistance
Molecules, 2020 Fluoroquinolones (FQs) are arguably among the most successful antibiotics of recent times. They have enjoyed over 30 years of clinical usage and become essential tools in the armoury of clinical treatments. FQs target the bacterial enzymes DNA gyrase and
Natassja G. Bush +3 more
doaj +1 more source
Safety of Antibacterial and Antiprotozoal Medicinal Products
Безопасность и риск фармакотерапии, 2022 The experts of the Scientific Centre for Expert Evaluation of Medicinal Products analysed administrative decisions of foreign regulatory authorities on the recalls of antibacterial and antiprotozoal medicinal products and/or the need for labelling ...
E. V. Shubnikova +5 more
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Bacterial carbonic anhydrases as drug targets: towards novel antibiotics ?
Frontiers in Pharmacology, 2011 Carbonic anhydrases (CAs, EC 4.2.1.1) are metalloenzymes which catalyze the hydration of carbon dioxide to bicarbonate and protons. Many pathogenic bacteria encode such enzymes belonging to the a-, b-, and/or g-CA families.
Claudiu T. Supuran
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Audit of Antibiotic Prescription in Suspected Neonatal Sepsis at an Indian Tertiary Care Hospital
Pharmacology and Clinical Pharmacy Research, 2022 Neonatal sepsis is one of the most typical causes of neonatal morbidity and mortality in the developing world. Rational use of antibacterial is a priority to prevent the emergence of resistance and to reduce the burden of treatment failure.
Geetha S +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Effect of antibacterials on rate of disease progression.
, 2012 Mean rate of spread of disease lesions (± standard errors) on T. mesenterina fragments maintained at 26°C in the presence and absence of antibacterials.
Scott Godwin (140358) +3 more
core +1 more source
Journal of Health (JOH), 2014 Background: Bacteria Shigella dysenteriae is pathogenic bacterium which cause diarrheal diseases that enter into inside the body through intestine. Shigella dysenteriae constitute one of the gram negative bacterium which causes inflammation on intestinal,
Fitri Nadifah +2 more
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