Results 31 to 40 of about 889,789 (245)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Antibiotics produced by Streptomyces
Brazilian Journal of Infectious Diseases, 2012 Streptomyces is a genus of Gram-positive bacteria that grows in various environments, and its shape resembles filamentous fungi. The morphological differentiation of Streptomyces involves the formation of a layer of hyphae that can differentiate into a ...
Rudi Emerson de Lima Procópio +4 more
doaj +3 more sources
Paper del farmacèutic en l’automedicació. UCD Costa de Ponent [PDF]
, 2014 Treballs d'Educació Farmacètica als ciutadans. Unitat Docent d'Estades en Pràctiques Tutelades.
Fernández Sala, Xènia +2 more
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
AntibioticsWith this notice, the Antibiotics Editorial Office states its awareness of concerns relating to the originality of the concepts and analysis published in this review [...]
Antibiotics Editorial Office
doaj +1 more source
En cirurgia de còlon, són realment necessaris els antibiòtics orals? [PDF]
, 2006 Abans de sotmetre al pacient a una cirurgia de còlon li són administrats sistemàticament antibiòtics orals. És necessària aquesta medicació? Investigadors de l'Hospital Vall d'Hebron i la UAB creuen que no.
Espin-Basany, Eloy
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Antibiotics, 2016 RNase P is an essential endonuclease in tRNA biogenesis, which generates the mature 5′-termini of tRNAs. Most forms of RNase P are ribonucleoproteins, i.e., they consist of an essential RNA and protein subunits.
Denis Drainas
doaj +1 more source
Epidemiologia de la Peritonitis Bacteriana Espontània en el nostre medi [PDF]
, 2012 Objectius: . Descriure l'epidemiologia de les PBE del nostre hospital. Material i Mètodes: S'analitzen les característiques de les PBE diagnosticades entre 2007-2010. Resultats: S'identificaren 44 episodis (73% extrahospitalàries).
Leal i Valdivieso, Carles +3 more
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source