Discovery of Kasugamycin as a Potent Inhibitor of Glycoside Hydrolase Family 18 Chitinases
Frontiers in Molecular Biosciences, 2021 Kasugamycin, a well-known aminoglycoside antibiotic, has been used widely in agriculture and medicine to combat microbial pathogens by binding the ribosome to inhibit translation.
Tian Liu, Qing Yang
exaly +3 more sources
Effects of Kasugamycin on the Translatome of Escherichia coli. [PDF]
PLoS ONE, 2017 It is long known that Kasugamycin inhibits translation of canonical transcripts containing a 5'-UTR with a Shine Dalgarno (SD) motif, but not that of leaderless transcripts.
Christian Lange +7 more
doaj +7 more sources
Phage Cocktail in Combination with Kasugamycin as a Potential Treatment for Fire Blight Caused by Erwinia amylovora [PDF]
Antibiotics, 2022 Recently, there has been an increasing number of blight disease reports associated with Erwinia amylovora and Erwinia pyrifoliae in South Korea. Current management protocols that have been conducted with antibiotics have faced resistance problems and the
Sang-Guen Kim +12 more
doaj +2 more sources
Insights into the Stress Response Triggered by Kasugamycin in Escherichia coli
Antibiotics, 2016 The bacteriostatic aminoglycoside antibiotic kasugamycin inhibits protein synthesis at an initial step without affecting translation elongation. It binds to the mRNA track of the ribosome and prevents formation of the translation initiation complex on ...
Isabella Moll, Moll Isabella
exaly +3 more sources
The translation inhibitors kasugamycin, edeine and GE81112 target distinct steps during 30S initiation complex formation [PDF]
Nature CommunicationsDuring bacterial translation initiation, the 30S ribosomal subunit, initiation factors, and initiator tRNA define the reading frame of the mRNA. This process is inhibited by kasugamycin, edeine and GE81112, however, their mechanisms of action have not ...
Haaris A. Safdari +8 more
doaj +2 more sources
In Vitro Response of Two Strains of Cordyceps javanica to Six Chemical Pesticides [PDF]
Journal of FungiTo determine the compatibility of two new biocontrol fungi with common chemical pesticides, this study examined the effects of three insecticides, namely, avermectin, imidacloprid, and acetamiprid, and three fungicides, namely, chlorogenonil, boscalid ...
Ruixia Mao +8 more
doaj +2 more sources
Pathogenicity, phylogenomic, and comparative genomic study of Pseudomonas syringae sensu lato affecting sweet cherry in California [PDF]
Microbiology SpectrumTo gain insights into the diversity of Pseudomonas syringae sensu lato affecting sweet cherry in California, we sequenced and analyzed the phylogenomic and genomic architecture of 86 fluorescent pseudomonads isolated from symptomatic and asymptomatic ...
Tawanda E. Maguvu +7 more
doaj +2 more sources
Kasugamycin Inhibits Melanoma Lung Metastasis and CHI3L1-Driven M2-Like Tumor-Associated Macrophage Differentiation [PDF]
ImmunoTargets and TherapyTakayuki Sadanaga,1,* Han-Seok Jeong,1,* Roberto Cortez,2 Joyce H Lee,3 Suchitra Kamle,1 Bing Ma,1 Sung Jae Shin,4 Jack A Elias,1 Chun Geun Lee1,5 1Department of Molecular Microbiology and Immunology, Brown University, Providence, RI, USA;
Sadanaga T +8 more
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RejuAgro A as an antimicrobial for fire blight control of pome fruits and beyond [PDF]
Nature CommunicationsFire blight, caused by Erwinia amylovora, severely impacts global apple and pear production. Current control measures rely heavily on conventional antibiotics like streptomycin, oxytetracycline, and kasugamycin, which raise concerns regarding resistance ...
Jian Huang +13 more
doaj +2 more sources
Phylogenomic analyses and comparative genomics of Pseudomonas syringae associated with almond (Prunus dulcis) in California. [PDF]
PLoS ONEWe sequenced and comprehensively analysed the genomic architecture of 98 fluorescent pseudomonads isolated from different symptomatic and asymptomatic tissues of almond and a few other Prunus spp. Phylogenomic analyses, genome mining, field pathogenicity
Tawanda E Maguvu +14 more
doaj +2 more sources