Results 41 to 50 of about 875,864 (245)

Epidemiologia de la Peritonitis Bacteriana Espontània en el nostre medi [PDF]

open access: yes, 2012
Objectius: . Descriure l'epidemiologia de les PBE del nostre hospital. Material i Mètodes: S'analitzen les característiques de les PBE diagnosticades entre 2007-2010. Resultats: S'identificaren 44 episodis (73% extrahospitalàries).
Leal i Valdivieso, Carles   +3 more
core  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

β-Lactam Antibiotics Renaissance

open access: yesAntibiotics, 2014
Since the 1940s β-lactam antibiotics have been used to treat bacterial infections. However, emergence and dissemination of β-lactam resistance has reached the point where many marketed β-lactams no longer are clinically effective.
Wenling Qin   +2 more
doaj   +1 more source

Alternatives als antibiòtics : estudi comparatiu entre ribonucleases [PDF]

open access: yes, 2010
Els microorganismes poden arribar a presentar resistència envers els antibiòtics quan s'ha produït un excés en el seu ús. Noves línies de recerca estan desenvolupant fàrmacs que minimitzin el risc de resistència i que presentin una activitat similar a la
Boix i Borràs, Esther
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Tetraciclines [PDF]

open access: yes, 2005
Les tetraciclines són agents antimicrobians d'ampli espectre que exhibeixen activitat davant una gran varietat de bacteris grampositius i gramnegatius. Aquests antibiòtics actuen inhibint la síntesi proteica unint-se a la subunitat 30S del ribosoma.
Ribera, Anna
core  

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

open access: yesMolecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy   +9 more
wiley   +1 more source

Can Eucalyptol Replace Antibiotics?

open access: yesMolecules, 2021
One of the primary reasons for the search for new antimicrobial agents is the increasing and spreading resistance of microorganisms to previously used drugs.
Wanda Mączka   +4 more
doaj   +1 more source

Els Pinsos industrials: seguretat o risc? (1a part) [PDF]

open access: yes, 2007
L'evolució històrica, en l'era moderna, dels coneixements científics de la nutrició, tant humana com animal, és un seguit de propostes, dades experimentals i descobriments de les funcions de components dels aliments, com les vitamines i les proteïnes ...
Puchal Mas, Francesc
core   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

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