Results 51 to 60 of about 875,864 (245)

Resistance to antibiotics [PDF]

open access: yesMedicamentul Veterinar, 2007
The antibiotics represent the most important therapeutic arsenal in the fight against pathogen microorganisms. Even in the beginning of their use, there was registered bacterial resistance, phenomenon thatbecame an alarming subject in the last decades ...
Oros N.A.,   +4 more
doaj  

Health Economics of Antibiotics

open access: yesPharmaceuticals, 2010
Antibiotics have made a significant contribution to improving patient health, but policy makers and health care payers are concerned about the costs of antibiotics in addition to their effectiveness.
Steven Simoens
doaj   +1 more source

Can Bacteriophages Replace Antibiotics?

open access: yesAntibiotics, 2022
Increasing antibiotic resistance numbers force both scientists and politicians to tackle the problem, and preferably without any delay. The application of bacteriophages as precision therapy to treat bacterial infections, phage therapy, has received ...
Mikael Skurnik
doaj   +1 more source

El problema de la fugida de l'anastomosi : antibiòtics en cirurgia colorectal [PDF]

open access: yes, 2007
Les operacions quirúrgiques colorectals (en les quals s'intervé sobre el colon, el recte o ambdós) poden presentar complicacions. Una d'aquestes complicacions és la fugida de l'anastomosi, la unió que es fa entre els extrems que han quedat oberts després
Oller Sales, Benjamín
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Macròlids: mecanismes d'acció i de resistència [PDF]

open access: yes, 2005
Els macròlids són agents descrits per primera vegada als anys cinquanta, molt emprats en el tractament de microorganismes grampositius. Actuen al ribosoma, unint-se de manera reversible a la subunitat 50S. Actualment se'n coneixen diferents mecanismes de
Portillo, Aránzazu   +2 more
core  

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

Influència de l'ètnia en el comportament farmacocinètic dels antibiòtics [PDF]

open access: yes, 2014
Un estudi retrospectiu realitzat a l'Hospital del Mar ha investigat la relació entre l'antibiòtic amikacina i l'ètnia dels pacients tractats amb ell entre gener de 2003 i desembre de 2010.
Barrantes-González, Melisa   +1 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Els bacteris escampen la resistència indiscriminada als antibiòtics [PDF]

open access: yes, 2009
La pertorbació de la replicació de material genètic dels bacteris indueix una resposta cel·lular (anomenada SOS) que genera la reordenació dels seus cromosomes i la captació, l'expansió i l'expressió d'una família d'elements genètics mòbils, coneguts com
Barbé García, Jordi
core   +1 more source

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