Results 61 to 70 of about 875,864 (245)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
, 2005 Es fa un breu repàs a un seguit d'antimicrobians, analitzant els seus mecanismes d'acció i els principals mecanismes de resistència.A brief report of action mechanisms in a series of antimicrobial agents is performed, taking resistance mechanisms into ...
Santos, Carmen +2 more
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Detecció d'antibiòtics en el vacú lleter [PDF]
, 2013 Treball presentat a l'assignatura de Deontologia i Veterinària Legal ...
Pastor Ripoll, Aida +2 more
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Xiehe Yixue ZazhiTo standardize the use of antibiotics for surgical prophylaxis, ensure patient safety, improve medical quality, and combat bacterial resistance, the editorial committee at Peking Union Medical College Hospital for the management of antibiotics for ...
Editorial Committee on Management Standard on Perioperative Prophylactic Use of Antibiotics in Peking Union Medical College Hospital
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Resistències als antibiòtics La responsabilitat del Veterinari en l'aparició i la prevenció [PDF]
, 2011 Treball presentat a l'assignatura de Deontologia i Veterinària Legal ...
Cantavella Corredor, Jana +1 more
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Dispensació d'antibiòtics sense recepta a les oficines de farmàcia [PDF]
, 2014 Introducció: L'ús indiscriminat d'antibiòtics, l'augment de les resistències i la mancança d'investigació en nous antibiòtics fa que ens trobem en un moment de crisi antibiòtica on cal prendre ...
Guinovart i Moncunill, Maria Candela +2 more
core +1 more source