Results 161 to 170 of about 1,001 (209)
Advanced Science, EarlyView.Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao +15 more
wiley +1 more source
Advanced Science, EarlyView.Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao +9 more
wiley +1 more source
Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target
Advanced Science, EarlyView.Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen +12 more
wiley +1 more source
Advanced Science, EarlyView.Flux‐protection engineering stabilizes an oxidation‐prone L‐DOPA node in engineered E. coli by combining acid‐adapted chassis evolution, respiratory‐chain modulation, enzyme‐level flux matching, and pH–DO control. Carbon is redirected from oxidative browning to productive biosynthesis, enabling 1075.2 mg/L curcumin and demonstrating transferability to ...
Jianbin Chen +10 more
wiley +1 more source
Advanced Science, EarlyView.A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie +7 more
wiley +1 more source
Advanced Science, EarlyView.In collegiate endurance athletes, a 6‐week randomized CPYE intervention yielded time‐ and sex‐dependent shifts in field‐based cardiorespiratory, metabolic, and redox indices, accompanied by changes in gut multi‐omics profiles. An exploratory extension during intensified training generates hypotheses warranting future validation.
Meng Zhang +8 more
wiley +1 more source
An Injectable, Self‐Expanding Hemostatic Foam for Field‐Compatible Postpartum Hemorrhage Management
Advanced Science, EarlyView.Postpartum hemorrhage is the leading cause of maternal death worldwide, yet many treatments are hard to use outside well‐equipped hospitals. This work introduces an easy‐to‐use device that rapidly delivers a degradable foam into the uterus. The foam stops bleeding through pressure and clotting support, offering a practical option for low‐resource ...
Charlotte Meyer +12 more
wiley +1 more source
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Hazards of Using Antibiotic Growth Promoters in the Poultry Industry
2022The poultry industry is one of the significant hubs of the livestock industry and the world's largest food industry. In the last 50 years, it has become common to observe poultry antibiotic feeding to treat disease and growth. Antibiotics inhibit the growth of toxic and beneficial microorganisms.
Alagawany, Mahmoud +8 more
openaire +3 more sources
Economics of Antibiotic Growth Promoters in Livestock
Annual Review of Resource Economics, 2015Rapidly rising incomes are driving demand for animal protein and livestock globally. The move toward more intensive production systems to support this increased demand is projected to increase the dependence on antibiotic growth promoters. The volume of antibiotics used for growth promotion in livestock outstrips that used for disease treatment in ...
Aude Teillant +2 more
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Alternatives To Antibiotic Growth Promoters in Broiler Production
2022In the U.S., with implementation of the Veterinary Feed Directive in 2017, medically important antibiotics are no longer available for growth promotion and finding alternatives continues to be a high priority for the livestock industry.
George Tabler +4 more
openaire +1 more source