Results 1 to 10 of about 1,234,048 (260)

Characterization of Enterobacterales growing on selective CPE screening plates with a focus on non-carbapenemase-producing strains

Microbiology Spectrum
Carbapenem-resistant Enterobacterales (CRE) are divided into two distinct groups: carbapenemase-producing (CPE) and non-carbapenemase-producing (non-CPE).
Reut Efrati Epchtien, Elizabeth Temkin, Mor N. Lurie-Weinberger, Ophir Kastel, Alona Keren-Paz, David Schwartz, Yehuda Carmeli   +6 more
doaj   +1 more source

Improving antibiotic stewardship skills through interdisciplinary online education: a multicenter teaching intervention for physicians and pharmacists

BMC Medical Education
Background Effective antibiotic prescribing is a core competency for physicians and pharmacists in combating antimicrobial resistance. Despite this, many healthcare professionals report limited confidence in applying antibiotic stewardship principles in ...
Till Koch, Johannes Jochum, Annika van der Linde, Friederike Jahn, Anika Neubert, Evelyn Kramme, Anette Friedrichs   +6 more
doaj   +1 more source

An antiplasmid system drives antibiotic resistance gene integration in carbapenemase-producing Escherichia coli lineages

Nature Communications
Plasmids carrying antibiotic resistance genes (ARG) are the main mechanism of resistance dissemination in Enterobacterales. However, the fitness-resistance trade-off may result in their elimination.
Pengdbamba Dieudonné Zongo, Nicolas Cabanel, Guilhem Royer, Florence Depardieu, Alain Hartmann, Thierry Naas, Philippe Glaser, Isabelle Rosinski-Chupin   +7 more
doaj   +1 more source

Comparison of testing methods assessing the in vitro efficacy of the combination of aztreonam with avibactam on multidrug-resistant Gram-negative bacilli

Annals of Clinical Microbiology and Antimicrobials
Background Aztreonam-avibactam (ATM-AVI) combination shows promising effectiveness on most carbapenemase-producing Gram-negatives, yet standardized antibiotic susceptibility testing (AST) methods for evaluating the combination in clinical laboratories is
Corentin Deckers, Florian Bélik, Olivier Denis, Pierre Bogaerts, Isabel Montesinos, Catherine Berhin, Warda Bouchahrouf, Martin Hoebeke, Stephanie Evrard, Nicolas Gilliard, Merve Okur, Te-Din Huang   +11 more
doaj   +1 more source

In vitro activity of flomoxef, fosfomycin, and amikacin versus a global panel of third-generation cephalosporin-resistant Enterobacterales and prediction of their ability in pairwise combinations to work as carbapenem-sparing regimens

Journal of Global Antimicrobial Resistance
Objective: Third-generation cephalosporin-resistant Gram-negative bacteria are the major cause of neonatal sepsis. Here we predicted the ability of flomoxef, fosfomycin, and amikacin in pairwise combinations to work as carbapenem-sparing regimens for the
Thea Brennan-Krohn, Maëlle Duffey, Stephen Hawser, Nimmi Kothari, François Franceschi, Renata M.A. da Costa   +5 more
doaj   +1 more source

A single amino acid substitution in SED-2 β-lactamase leads to increased inhibitor resistance and an extended substrate spectrum

Microbiology Spectrum
β-Lactamases are the leading mechanism of resistance to β-lactam antibiotics in Enterobacterales. Here, we report the detection and characteristics of SED-2, a new member of the Citrobacter sedlakii class A chromosomal β-lactamase SED family.
S. Laviad-Shitrit, H. Kon, D. Bychenko Banyas, R. Efrati Epchtien, M. Bechor, M. Lurie-Weinberger, E. Ben-Zeev, S. Frank, N. Rakovitsky, D. Schwartz, A. Keren-Paz, Y. Carmeli   +11 more
doaj   +1 more source

Zophobas morio larvae as a novel model for the study of Acinetobacter virulence and antimicrobial resistance

Frontiers in Microbiology
The use of mammalian models for in vivo testing of bacterial virulence raises ethical concerns and is expensive and time-consuming. As an alternative, non-mammalian models are sought.
Nadya Rakovitsky, Elizabeth Temkin, Amichay Hameir, Mor Lurie-Weinberger, Alona Keren-Paz, Yehuda Carmeli, Yehuda Carmeli   +6 more
doaj   +1 more source

Contribution of Fourier transform infrared spectroscopy for outbreak investigation of carbapenem-resistant Acinetobacter baumannii

Microbiology Spectrum
The value of Fourier transform infrared (FTIR) spectroscopy as an investigation tool for outbreaks caused by Acinetobacter baumannii remains inconclusive. Here, we used FTIR as a real-time tool to investigate a carbapenem-resistant A.
Hadas Kon, Mor N. Lurie-Weinberger, Dafna Chen, Hani Laderman, Elizabeth Temkin, Elena Lomansov, Ibraheem Firan, Worood Aboalhega, Marina Raines, Alona Keren-Paz, Yehuda Carmeli   +10 more
doaj   +1 more source

Linezolid Resistance Genes and Mutations among Linezolid-Susceptible Enterococcus spp.—A Loose Cannon?

Antibiotics
The National Reference Centre for Enterococci receives an increasing number of linezolid-resistant Enterococcus isolates. Linezolid (LIN) resistance is mediated by G2576T 23S rDNA gene mutations and/or acquisition of resistance genes (cfr, optrA, poxtA).
Jennifer K. Bender, Carola Fleige, Finn Funk, Clara Moretó-Castellsagué, Martin A. Fischer, Guido Werner   +5 more
doaj   +1 more source

In vivo interspecies dissemination of IncM2-type blaNDM-1 carrying plasmid

Microbiology Spectrum
The gastrointestinal tract is a unique ecological niche with a high abundance of various Enterobacterales in close proximity. This allows the exchange of mobile genetic elements that carry resistance determinants.
Mor N. Lurie-Weinberger, Darya Bychenko-Banyas, Meirav Mor, Sivan Laviad-Shitrit, Ella Kaplan, Nadya Rakovitsky, Alona Keren-Paz, Chaim Ben-Zvi, Yehuda Carmeli   +8 more
doaj   +1 more source