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Mobile resistome of human gut and pathogen drives anthropogenic bloom of antibiotic resistance [PDF]

open access: yesMicrobiome, 2020
Background The impact of human activities on the environmental resistome has been documented in many studies, but there remains the controversial question of whether the increased antibiotic resistance observed in anthropogenically impacted environments ...
Kihyun Lee   +12 more
doaj   +2 more sources

Inflammatory Endotype-Associated Airway Resistome in Chronic Obstructive Pulmonary Disease

open access: yesMicrobiology Spectrum, 2022
Antimicrobial resistance is a global concern in chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD). The collection of antibiotic resistance genes or resistome in human airways may underlie the resistance.
Xinzhu Yi   +16 more
doaj   +1 more source

Colistin-degrading proteases confer collective resistance to microbial communities during polymicrobial infections

open access: yesMicrobiome, 2022
Background The increasing prevalence of resistance against the last-resort antibiotic colistin is a significant threat to global public health. Here, we discovered a novel colistin resistance mechanism via enzymatic inactivation of the drug and proposed ...
Do-Hoon Lee   +7 more
doaj   +1 more source

Antibiotic resistome in groundwater and its association with mountain springs and river

open access: yesEcotoxicology and Environmental Safety, 2023
The distribution of antibiotic resistance genes (ARGs) in water sources potentially threatens drinking water safety. However, the sources of antibiotic resistome in groundwater are still under-investigated.
Fu-Yi Huang   +7 more
doaj   +1 more source

Metagenomic binning and assembled genome analysis revealed the distinct composition of resistome and mobilome in the Ili River

open access: yesEcotoxicology and Environmental Safety, 2022
Rivers play an important role in receiving and transporting the resistome among different environmental compartments. However, the difference in resistome and mobilome between the water and sediment and their underlying mechanisms were still poorly ...
Wenjuan Song   +4 more
doaj   +1 more source

Transition of antimicrobial resistome in wastewater treatment plants: impact of process configuration, geographical location and season

open access: yesnpj Clean Water, 2023
Antimicrobial resistome in wastewater treatment plants was investigated via shotgun metagenomic analysis over a variety of geographical locations, seasons, and biological treatment configurations.
Ryo Honda   +9 more
doaj   +1 more source

Antibiotic resistance in chronic respiratory diseases: from susceptibility testing to the resistome

open access: yesEuropean Respiratory Review, 2022
The development of resistome analysis, i.e. the comprehensive analysis of antibiotic-resistance genes (ARGs), is enabling a better understanding of the mechanisms of antibiotic-resistance emergence. The respiratory microbiome is a dynamic and interactive
Hélène Pailhoriès   +6 more
doaj   +1 more source

Population-based variations of a core resistome revealed by urban sewage metagenome surveillance

open access: yesEnvironment International, 2022
Sewage-based surveillance is widely employed to understand the occurrence and distribution of antimicrobial resistance (AMR) in urban community. However, there are limited studies which investigated the sewage of different sources within community.
Wenxuan Li   +9 more
doaj   +1 more source

Description and determinants of the faecal resistome and microbiome of farmers and slaughterhouse workers: A metagenome-wide cross-sectional study

open access: yesEnvironment International, 2020
Background: By studying the entire human faecal resistome and associated microbiome, the diversity and abundance of faecal antimicrobial resistance genes (ARGs) can be comprehensively characterized.
Liese Van Gompel   +20 more
doaj   +1 more source

Human Gut Antibiotic Resistome and Progression of Diabetes

open access: yesAdvanced Science, 2022
The antibiotic resistance crisis underlies globally increasing failures in treating deadly bacterial infections, largely due to the selection of antibiotic resistance genes (ARG) collection, known as the resistome, in human gut microbiota. So far, little
Menglei Shuai   +14 more
doaj   +1 more source

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