Results 41 to 50 of about 1,001 (209)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Antibiotic Use in Livestock: A Driver of Resistance in Africa and the Path to Safer Alternatives

MicrobiologyOpen
Antibiotics are widely used in animal production for disease treatment, prevention, and as growth promoters at subtherapeutic doses. Across Africa, various antibiotic classes, including beta‐lactams, macrolides, tetracyclines, phenicols, fluoroquinolones,
Mercy A. Alabi, Hafizah Y. Chenia, Johnson Lin   +2 more
doaj   +1 more source

In vitro Antibacterial Efficacy of Non-Antibiotic Growth Promoters in Poultry Industry

The Journal of Poultry Science, 2020
Antibiotic growth promoters (AGPs) have been used for many years as supplements in various livestock diets, including those for poultry. However, the use of AGPs in feed was also associated with an increasing number of antibiotic-resistant bacteria in ...
Mashael R. Aljumaah, Manal M. Alkhulaifi, Alaeldein M. Abudabos   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Development and Evaluation of Non-Antibiotic Growth Promoters for Food Animals

Veterinary Sciences
The widespread utilization of antibiotic growth promoters (AGPs) boosts the growth rate of food animals and enhances human living standards. Nevertheless, it is accompanied by escalating antibiotic resistance.
Hanfei Wang, Hengji Zhao, Bocheng Tai, Simeng Wang, Awais Ihsan, Haihong Hao, Guyue Cheng, Yanfei Tao, Xu Wang   +8 more
doaj   +1 more source

The Study of Different Growth Promoters on Growth Performance, Intestinal Bacteriology and Haematological Chracteristics

Journal of Pure and Applied Microbiology, 2018
Probiotics are rich sources of viable microorganisms (bacteria or yeasts) and these have a beneficial effect on host health after ingestion. This trial was conducted to assess the effects of growth performance of broilers fed on diets containing ...
Raed Hussein Salih Rabee, Yahya Sabah Abdulameer   +1 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The sub-inhibitory theory for antibiotic growth promoters

Poultry Science, 2017
Antibiotics have played a critical role in the prevention, control, and treatment of bacterial diseases in humans and animals, and as growth promoters (AGPs) when used at sub-therapeutic concentrations in animal production. Numerous hypotheses have been proposed for the effectiveness of AGPs, which have largely centered on the beneficial modulation of ...
openaire   +2 more sources

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source