Results 171 to 180 of about 126,613 (289)

Discovery and Biosynthesis of the Novel Glycotetrapeptide Antibiotic Biffamycin A

Angewandte Chemie, EarlyView.
Genetic de‐regulation of a silent biosynthetic pathway allowed isolation and characterisation of a novel glycopeptide antibiotic named biffamycin A, which harbours unprecedented 5‐chloro‐4‐methoxy tryptophan and 3R‐hydroxy(α‐D‐mannoysl)‐D‐lysine moieties and is bioactive against MRSA and VRSA.
Michael W. Brigham, Edward S. Hems, Daniel C. L. Van, Justin E. Clarke, Sergey Nepogodiev, Julius S. P. Adamson, Christian Bassi, Michael E. Webb, Glyn R. Hemsworth, Orde Q. Munro, Barrie Wilkinson, Ryan F. Seipke   +11 more
wiley   +2 more sources

Nanomotion-enabled ultra-rapid antibiotic susceptibility testing with magnetic bead-based pathogen enrichment for accelerated sepsis diagnostics. [PDF]

Sci Rep
Jóźwiak G, Pla Verge M, Luraschi-Eggemann A, Mestiri C, McSorley E, Wilson-Owen D, La Fauci S, García-Castillo M, Delarze E, Fromm K, Munch L, Vogel C, Balasopoulos D, Cathomen G, Reiter S, Świątkowski M, Totu R, Häussler S, Tenson T, Pagliara S, Cantón R, Greub G, Lisby G, Mullen W, Lockhart D, Cichocka D, Sturm A, ERADIAMR consortium.   +27 more
europepmc   +1 more source

Interspecies Biofilm Dynamics Among Staphylococci: Inflammatory Contributions to Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Introduction Staphylococcus species are frequently isolated from the sinonasal niche of chronic rhinosinusitis (CRS) patients. While Staphylococcus aureus is often associated with recalcitrant CRS, Staphylococcus epidermidis and Staphylococcus lugdunensis are largely deemed commensal.
Sintayehu Ambachew, Mahnaz Ramezanpour, Clare M. Cooksley, Sholeh Feizi, Muhammed Awad, Kevin Aaron Fenix, Peter‐John Wormald, Alkis J. Psaltis, Sarah Vreugde   +8 more
wiley   +1 more source

Comparison of <i>in vitro</i> antibiotic susceptibility testing of <i>R. typhi</i> using plaque assay and quantitative real-time PCR. [PDF]

Microbiol Spectr
Phuklia W, Padith K, Farris CM, Richards AL, Phommasone K, Mayxay M, Mukaka M, Robinson MT, Newton PN, Day NPJ, Ashley EA.   +10 more
europepmc   +1 more source

Genetic prediction of blood cell reactivity and its potential causal influence on bone continuity and density disorders

Animal Models and Experimental Medicine, EarlyView.
We applied Mendelian randomization to explore causal links between blood cell traits and skeletal disorders. Using genetic instruments from large‐scale summary statistics, we assessed effects on bone continuity, density, and structural integrity. Sensitivity and reverse analyses confirmed robust associations, highlighting potential shared biological ...
Zhiqin Deng, Zhe Zhao, Wenting Jiang, Xiaoqiang Chen, Jianquan Liu, Xu Tao, Zhengyang Lin, Zhenhan Deng, Wencui Li   +8 more
wiley   +1 more source

Accuracy of rapid microcapillary direct antibiotic susceptibility testing for urine samples collected with bacteriostatic boric acid from patients with suspected urinary tract infection. [PDF]

JAC Antimicrob Resist
Needs SH, Lam H, Hayward JE, Sharma R, Gurung M, Hancox O, Hart J, Kidd SP, Edwards AD.   +8 more
europepmc   +1 more source

Nanodiamonds as Bioactive Platforms to Modulate Microbial, Mammalian, and Vertebrate Systems

Advanced NanoBiomed Research, EarlyView.
Nanodiamonds (NDs) are biocompatible and antibacterial nanomaterials that support mammalian cell growth while inhibiting bacterial pathogens. NDs showed strong antibacterial activity, with Escherichia coli being more sensitive than Staphylococcus aureus. At 10 mg/mL, both bacteria exhibited ~8% viability.
Aaqil Rifai, Ayushi Priyam, Ahmed Rashed, Gebreselassie Addisu Tilaye, Kamal Poudel, Aaron G. Schultz, Richard J. Williams   +6 more
wiley   +1 more source

Full Validation of Pooled Antibiotic Susceptibility Testing Using CLSI Methods and Performance Criteria in UTI Pathogens. [PDF]

Antibiotics (Basel)
Festa RA, Cockerill FR, Pesano RL, Haley E, Luke N, Mathur M, Chen X, Havrilla J, Percaccio M, Rosas A, Magallon J, Erickson S, Ghashghaie M, Sinatra J, Gonzalez V, Baunoch D.   +15 more
europepmc   +1 more source

Human Leukocyte Elastase Triggered Nanoparticles for Targeted Antimicrobial Delivery and Oral Microbial Modulation

Advanced NanoBiomed Research, EarlyView.
This study explores enzyme‐responsive nanoparticles for targeted antimicrobial release in inflamed oral environments. Nanoparticles formed by complexing peptides and chlorhexidine respond to human leukocyte elastase and release chlorhexidine selectively. P7 (ECAAPVCE)‐based formulations show optimal properties and stability, with antimicrobial activity
Mohammed A. Hadis, Ignacio Insua, Farah N. S. Raja, Álvaro Vila, William M. Palin, Michael R. Milward, Paul R. Cooper, Sarah A. Kuehne, Owen Addison, Paco Fernandez‐Trillo   +9 more
wiley   +1 more source

Colorimetric Ready-to-Use Microfluidic Chips for Rapid Antibiotic Susceptibility Testing of Methicillin-Resistant <i>Staphylococcus aureus</i> by a Smartphone-Based Analysis. [PDF]

ACS Omega
Celik Yoldas C, Ildiz N, Demir NY, Duman M, Yoldas E, Kucukgunay S, Erol K, Ocsoy I.   +7 more
europepmc   +1 more source