Results 201 to 210 of about 185,660 (297)

Investigating group A Streptococcus antibiotic tolerance in necrotizing fasciitis. [PDF]

mSphere
Keller N, Boumasmoud M, Andreoni F, Tarnutzer A, von Matt M, Scheier TC, Epprecht J, Weller D, Gómez-Mejia A, Huemer M, von Reibnitz D, Fontein DBY, Marques-Maggio E, Schuepbach RA, Mairpady-Shambat S, Brugger SD, Zinkernagel AS.   +16 more
europepmc   +1 more source

Altered Nasal Microbiota in Sinonasal Tumors: A Comparative Analysis of Malignant and Benign Sinonasal Tumors

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Although shifts in nasal microbiota have been well‐documented in inflammatory upper airway conditions, microbiota tumor‐associated alterations remain uncharacterized. This study is the first to compare sinonasal microbiota profiles of patients with malignant tumors (MT), benign tumors (BT), and controls, offering insights into tumor‐
Evan A. Patel, Phillip A. Engen, Glen D. Souza, Sarah Khalife, Donyea Moore, Lauren Kret, Pedro Escobedo, Stefan J. Green, Ankur Naqib, Peter Filip, Peter Papagiannopoulos, Bobby A. Tajudeen, Mahboobeh Mahdavinia, Pete S. Batra   +13 more
wiley   +1 more source

Dosing Interval Extension of Dupilumab in CRSwNP: Five‐Year Real World Outcomes

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a persistent, often Type 2‐mediated inflammatory disease that markedly impairs quality of life. While dupilumab provides rapid improvement, there is limited evidence on long‐term outcomes beyond 2 years, and the clinical impact of dosing‐interval extension remains unclear.
Nicholas J. Campion, Dioni‐Pinelopi Petsiou, Florian C. Fally, Karina Berbalk, Noah F. Melamed, Aldine Tu, Christina Morgenstern, Fana Alem Kidane, Mohammed Zghaebi, Linda Liu, Minghao Pan, Tina J. Bartosik, Victoria Stanek, Katarina Gangl, Julia Eckl‐Dorna, Sven Schneider   +15 more
wiley   +1 more source

FleQ finetunes the expression of a subset of BrlR-activated genes to enable antibiotic tolerance by <i>Pseudomonas aeruginosa</i> biofilms. [PDF]

J Bacteriol
Oladosu VI, Sauer K.
europepmc   +1 more source

Beyond PEGylation: Archaeal Lipids for Long‐Circulating Liposomes

Advanced NanoBiomed Research, EarlyView.
Archaeal lipid‐based liposomes, particularly those containing caldarchaeol (GDGT), were found to significantly prolong the circulation time of vancomycin in rats, matching the pharmacokinetic properties of PEGylated systems. These findings suggest archaeal lipids as promising non‐PEG excipients for parenteral applications to minimize drug clearance ...
Viktor Sedlmayr, Andreas D. Meid, Eric Mühlberg, Manuel Ben Böhmann, Julian Quehenberger, David Wurm, Mikko Gynther, Oliver Spadiut, Gert Fricker, Philipp Uhl   +9 more
wiley   +1 more source

The 10–23 DNAzyme in Biosensing and Diagnostics: Applications, Challenges, and Future Directions

Angewandte Chemie, EarlyView.
This review focuses on the 10–23 DNAzyme in diagnostics, spanning unregulated and regulated target‐recognition modes, and their functionalization across colorimetric, fluorescent, electrochemical, electrochemiluminescent, and intracellular biosensing strategies.
Connor Nurmi, Jake Brill, Sanne Roumans, Amal Mathai, John D. Brennan, Yingfu Li   +5 more
wiley   +2 more sources

Staphylococcus aureus COL: An Atypical Model Strain of MRSA That Exhibits Slow Growth and Antibiotic Tolerance due to a Mutation in PRPP Synthetase. [PDF]

Mol Microbiol
Stevens CE, Deventer AT, Johnston PR, Lowe PT, Boraston AB, Hobbs JK.   +5 more
europepmc   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

PBP4 is required for serum-induced cell wall thickening and antibiotic tolerance in Staphylococcus aureus. [PDF]

Antimicrob Agents Chemother
Ledger EVK, Massey RC.
europepmc   +2 more sources

Fluorinated Glycan Frameshifts: Automated Synthesis Expedites the Study of Glycan‐Protein Interactions by 19F‐BioNMR

Angewandte Chemie, EarlyView.
Given the prominence of 19F‐bioNMR in structural research, fluorinated glycans hold enormous potential in glycomimetic frameshift design. However, challenges associated with the stereocontrolled synthesis of these disruptive actors continue to frustrate advances. To address this, the automated synthesis of selectively C‐2 fluorinated glycans related to
James Suri, Christina Jordan, Charlotte S. Teschers, Kristina Schlangen, Simon H. Rüdisser, Alvar D. Gossert, Ryan Gilmour   +6 more
wiley   +2 more sources