Results 221 to 230 of about 15,407,593 (258)

Reframing Antimicrobial Stewardship as Systems Governance: Aligning Regulation, Diagnostics, Antibiotic Use Measurement, and Surveillance to Address Antimicrobial Resistance. [PDF]

Antibiotics (Basel)
Mayi B, Dharmapalan D, Shet A.
europepmc   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Knowledge, attitudes and behaviour of Swiss healthcare workers on antibiotic use and resistance: A cross-sectional study

Wichmann M, Grässli F, Dörr T, Kahlert CR, Vuichard-Gysin D, Badinski T, Stocker R, Ruetti M, Schlegel M, Kuster SP, Kohler P, Cusini A.   +11 more
europepmc   +1 more source

Optimizing Antibiotic Use for Urinary Tract Infections: A Qualitative Assessment of Regular Prescribing Practices. [PDF]

Yonsei Med J
Song JE, Lee Y, Park HW, Yun IJ, Heo SJ, Hyun JH, Park YS, Kim B, Kwak YG, Kim YC.   +9 more
europepmc   +1 more source

Programmable Encapsulation Enables On‐Demand Proliferation of Therapeutic Bacteria for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang, Ao Peng, Shuaiqiang Li, Yaning Huang, Jian Yan, Leyuan Wang, Zhihui Zhu, Fei‐Long Liu, Erbao Bian, Yang Liu, Dasheng Tian, Fenghe Li, Qi Liu   +12 more
wiley   +1 more source

O‐GlcNAcylation Regulation of SNAP29‐Dependent Autophagy Activation Dictates Chemoresistance in Gastric Cancer

Advanced Science, EarlyView.
Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang, Shaoji Zhao, Ziling Shao, Tao Luo, Baifu Peng, Yifan Liu, Jinning Ye, Jianjun Peng, Kaiyu Sun, Jianbo Xu   +9 more
wiley   +1 more source

The association between prenatal and early-life antibiotic use and obesity at 4-5 years in the Born in Bradford birth cohort. [PDF]

BMC Public Health
Goodwin L, Badrick E, Santorelli G, Souza da Cunha S, Petherick E, Oddie S, Pearce N, Wright J, Pembrey L.   +8 more
europepmc   +1 more source

Association between Broad-Spectrum Antibiotic Use and Risk of Early-Onset Colorectal Cancer. [PDF]

Cancer Epidemiol Biomarkers Prev
Chao CR, Xu L, Wu BU, Figueiredo JC, Getahun D, Cannavale KL, Gilfillan AD, Chubak J.   +7 more
europepmc   +1 more source

Knowledge and attitude toward antibiotic use and self-medication with antibiotics among medical students. [PDF]

Antimicrob Steward Healthc Epidemiol
Sae-Li P, Hanvivattanakul S, Nana R, Khawcharoenporn T.   +3 more
europepmc   +1 more source

Patterns of inpatient antibiotic use and antimicrobial resistance in the surgical wards of a Ugandan tertiary hospital: A mixed methods study. [PDF]

PLoS One
Magololo FM, Byonanebye D, Dhikusooka F, Twimukye A, Agaba D, Twinomuhwezi E, Mackline H, Namakula E, Emmanuel Elobu A, Orwotho Tholith N, Kakooza F, Kambugu A, Kajumbula H.   +12 more
europepmc   +1 more source