Results 171 to 180 of about 867,243 (251)

Nucleophilic Fluorination of a Secondary Alkyl Bromide with KF(18‐Crown‐6) and Bulky Diols: Microsolvation Causes Chemoselectivity Inversion in the Free Energy Profile

ChemPlusChem, EarlyView.
The combination of crown ether with strong hydrogen bond donor bulky diols enhances reactivity and SN2 selectivity in challenging fluorination reactions of secondary alkyl bromide substrates. Fluoride ion solvated in polar aprotic solvents works like bases and reacts with secondary alkyl bromide substrates mainly via E2 reactions, with minor formation ...
Luís F. Resende, Eloah P. Ávila, Josefredo R. Pliego   +2 more
wiley   +1 more source

Targeting the Tumor Microbiota in Cancer Therapy Basing on Nanomaterials

Exploration, EarlyView.
Intra‐tumoral microbiota, which is a potential component of the tumor microenvironment, has been emerging as a key participant and driving factor in cancer. This article reviews the latest progress in this field, including the microbial community within tumors and its pro‐cancer mechanisms, as well as the anti‐tumor strategies targeting intra‐tumoral ...
Yanan Niu, Junya Feng, Jie Ma, Tixian Xiao, Wei Yuan   +4 more
wiley   +1 more source

Cachexia during anti-leukemia chemotherapy: it is not "just" the chemo. [PDF]

Haematologica
Rashidi A.
europepmc   +1 more source

Synthetic Biology‐Based Engineering Living Therapeutics for Antimicrobial Application

Exploration, EarlyView.
This perspective highlights synthetic biology‐driven antibacterial strategies, focusing on three innovative approaches: engineered bacteriophages for precision bacterial targeting, reprogrammed microbes that detect quorum‐sensing signals or metabolites to release antimicrobials, and engineering mammalian cells that recognize pathogen‐associated ...
Shun Huang, Shuihao Zhao, Haijie Zhao, Mingzhang Wen, Zhong Guo   +4 more
wiley   +1 more source

Everolimus induced pneumonitis in a liver transplant patient: Dilemma in the discrimination of pneumonia. [PDF]

Turk J Surg
Sağlam K, Köse A, Yalçınsoy M, Bayındır Y, Yılmaz S.   +4 more
europepmc   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Characterization of Antineoplastic Agents Inducing Taste and Smell Disorders Using the FAERS Database. [PDF]

Pharmaceuticals (Basel)
Hamazaki R, Uesawa Y.
europepmc   +1 more source

Overcoming Toxicity Barriers for Boosting Nisin Synthesis in Lactococcus lactis Strain via Adaptive Laboratory Evolution

Food Chemistry International, EarlyView.
After adaptive laboratory evolution against nisin, improved nisin production and tolerance were found in the evolved strains. To reveal the advantages of the evolved strains, a systematic comparison was made between the starting strains and the domesticated strains in terms of their microscopic morphology, metabolomics, transcriptomics, and whole ...
Xinyue Liu, Yuwei Sun, Jiang Zhu, Fang Wang, Zhijia Liu, Yanfei Wang, Shengbao Cai, Junjie Yi   +7 more
wiley   +1 more source

Artificial intelligence in drug resistance management. [PDF]

3 Biotech
Elalouf A, Elalouf H, Rosenfeld A, Maoz H.   +3 more
europepmc   +1 more source

Natural Products Targeting Protein Disulfide Isomerases: New Frontiers for Diabetes, Cancer, and Coagulation

Food Frontiers, EarlyView.
PDIA4 is significantly upregulated in response to nutrient overload in pancreatic β‐cells, resulting in aberrant ROS production, β‐cell failure, and diabetes. PDIA4 facilitates cancer development by inhibiting caspase‐mediatedcell death in cancer and promoting VEGF‐mediated protumoral immunity andangiogenesis in the tumor microenvironment, highlighting
Yi‐San Lee, Catherine Ortega, Tien‐Fen Kuo, Greta Yang, Wen‐Chin Yang   +4 more
wiley   +1 more source