Results 181 to 190 of about 17,550 (209)

Antineutrophil cytoplasmic antibodies

American Journal of Medicine, 1992
Antineutrophil cytoplasmic antibodies (ANCA) have been described as sensitive and specific markers for active Wegener's granulomatosis (WG). ANCA in WG produce a characteristic cytoplasmic staining pattern of neutrophils (c-ANCA) and are directed against proteinase 3 (Pr3), a serine protease from the azurophilic granules.
Kallenberg, Cees G. M., Mulder, A. H. Leontine, Tervaert, Jan Willem Cohen   +2 more
openaire   +1 more source

Antineutrophil cytoplasmic antibodies in children

European Journal of Pediatrics, 1998
To define the diagnostic meaning of antineutrophil cytoplasmic antibodies (ANCA) positivity in children, we analysed 1485 consecutive sera sent for routine immunological investigation to our department from January to August 1996. Using this large screening, we identified the most typical clinical disorders associated with ANCA in childhood.
A, Sedivá, I, Kolárová, J, Bartůnková   +2 more
openaire   +2 more sources

Antineutrophil cytoplasmic antibody-associated neutropenia

European Journal of Internal Medicine, 2004
BACKGROUND: Antineutrophil cytoplasmic antibodies (ANCA) can be associated with various disorders. However, their association with neutropenia has never been reported. METHODS: Nine patients with chronic unexplained neutropenia and ANCA were studied. Clinical charts were extensively analyzed and all patients underwent hematological and immunological ...
Paul, Coppo, David, Ghez, Vincent, Fuentes, Djaouida, Bengoufa, Eric, Oksenhendler, Bruno, Tribout, Jean-Pierre, Clauvel, Kaiss, Lassoued   +7 more
openaire   +2 more sources

Antineutrophil cytoplasmic antibody-associated vasculitis

Current Opinion in Nephrology & Hypertension
Purpose of review This review focuses on latest developments in managing antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV), a systemic autoimmune condition characterized by inflammation and necrosis of small blood vessels due to circulating autoantibodies that target neutrophilic granules.
Raghunandan, Konda, Arun, Rajasekaran, Dana V, Rizk   +2 more
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The antineutrophil cytoplasmic antibody–associated vasculitides

The American Journal of Medicine, 2004
Wegener's granulomatosis, microscopic polyangiitis, and Churg-Strauss syndrome are small- to medium-vessel vasculitides linked by overlapping pathology and the presence of antineutrophil cytoplasmic antibodies (ANCA). Commonly referred to as the ANCA-associated vasculitides, these diseases are challenging to diagnose and to treat.
Philip, Seo, John H, Stone
openaire   +2 more sources

Testing for antineutrophil cytoplasmic antibodies

Expert Review of Molecular Diagnostics, 2001
The most common reason to request a test for antineutrophil cytoplasmic antibodies (ANCA) is to diagnose Wegener's granulomatosis and microscopic polyangiitis and to monitor inflammatory activity in these diseases. Several retrospective and prospective studies have suggested that the demonstration of ANCA lacks sensitivity and specificity, but these ...
openaire   +2 more sources

Antineutrophil cytoplasmic antibody-associated vasculitides

Joint Bone Spine, 2007
The identification of antineutrophil cytoplasmic antibodies (ANCA) proved a major breakthrough in the classification, diagnosis, monitoring, and understanding of vasculitides. Vasculitides associated with ANCA selectively affect the small vessels; they include Wegener granulomatosis, microscopic polyangiitis, and Churg-Strauss syndrome.
openaire   +2 more sources

Childhood antineutrophil cytoplasmic antibodies associated vasculitides

Current Opinion in Rheumatology, 2014
The purpose of this review is to discuss the most recent published literature in childhood antineutrophil cytoplasmic antibodies (ANCA) associated vasculitides and to identify the important issues arisen in the adult literature. This review will discuss the literature on new treatment regimens and outcome measurements.Antineutrophil cytoplasmic ...
Marinka, Twilt, Susanne, Benseler
openaire   +2 more sources

Antineutrophil Cytoplasmic Antibody–Associated Lung Fibrosis

Seminars in Respiratory and Critical Care Medicine, 2018
AbstractPulmonary fibrosis is observed in a substantial number of patients with ANCA-associated vasculitis (AAV), 15% in a recent German series, and may be more frequent in Asian populations. ANCA are usually of anti-MPO specificity and microscopic polyangiitis is the most frequent vasculitis.
Raphael, Borie, Bruno, Crestani
openaire   +2 more sources

Antineutrophil cytoplasmic antibodies (ANCA) and vasculitis

Clinical Rheumatology, 1990
The demonstration of autoantibodies to different myeloid lysozomal enzymes has opened a new area for the study of vasculitic syndromes. Autoantibodies producing a granular cytoplasmic staining by IIF (c-ANCA, probably directed to a putative serine protease) are closely associated with Wegener's granulomatosis.
openaire   +3 more sources