Results 131 to 140 of about 54,568 (249)

Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of Afimetoran, a Toll‐Like Receptor 7 and 8 Inhibitor, in Patients With Cutaneous Lupus Erythematosus: A Phase 1b Randomized, Double‐Blind, Placebo‐Controlled Study

ACR Open Rheumatology, Volume 7, Issue 7, July 2025.
Objective There is an unmet need for safe and effective oral treatments for cutaneous lupus erythematosus (CLE). Afimetoran is an investigational, first‐in‐class, orally bioavailable, selective small molecule inhibitor of Toll‐like receptors (TLRs) 7 and 8.
Fareeda Hosein, Stanislav Ignatenko, Kristina D. Chadwick, Lin Zhu, Frédéric Baribaud, Jasmine Saini, Thanh Bach, Urvi Aras, WanYing Zhang, Hazem Karabeber, Michelle Dawes, Melanie Harrison, Leonidas N. Carayannopoulos, Gopal Krishna   +13 more
wiley   +1 more source

COVID19‐Related Onset and Relapses of Juvenile Systemic Lupus Erythematosus‐Like Disease

Journal of Paediatrics and Child Health, EarlyView.
Chiara Cannata, Francesca Tirelli, Alessandra Meneghel, Francesco Zulian   +3 more
wiley   +1 more source

Immunology and Disease of Connective Tissue [PDF]

, 1977
Since immune responses play a major role in the development of connective tissue diseases, it is not surprising that a number of laboratory studies reflect these responses. Prior to the 1940s when rheumatoid and LE factors became widely known, one relied
Irby, Robert
core   +1 more source

Absence of Functional Autoantibodies Targeting Angiotensin II Receptor Type 1 and Endothelin‐1 Type A Receptor in Circulation and Purified IgG From Patients With Systemic Sclerosis

Arthritis &Rheumatology, Volume 77, Issue 7, Page 901-913, July 2025.
Objective Systemic sclerosis (SSc) is a rare but severe autoimmune disease characterized by immune dysregulation, fibrosis, and vasculopathy. Although previous studies have highlighted the presence of functional autoantibodies targeting the angiotensin II receptor type 1 (AT1) and endothelin‐1 type A receptor (ETAR), leading to autoantibody‐mediated ...
Wieke M. van Oostveen, Eva M. Hoekstra, E. W. Nivine Levarht, Ilana B. Kotliar, Thomas P. Sakmar, René E. M. Toes, Jeska K. de Vries‐Bouwstra, Laura H. Heitman, Cynthia M. Fehres   +8 more
wiley   +1 more source

Serum Type I Interferon Score for Prediction of Clinically Meaningful Disease Progression in Limited Cutaneous Systemic Sclerosis

Arthritis &Rheumatology, Volume 77, Issue 7, Page 929-941, July 2025.
Objective To assess the value of serum type I interferon (IFN) score in predicting clinically meaningful progression in limited cutaneous systemic sclerosis (lcSSc) using a novel composite endpoint adopted from the MINIMISE clinical trial. Methods A retrospective, longitudinal lcSSc cohort was identified within a national, multicenter observational ...
Stefano Di Donato, Rebecca Ross, Ranjitha Karanth, Vishal Kakkar, Enrico De Lorenzis, Lesley‐Anne Bissell, Kristina Clark, Philip Yee, Christopher P. Denton, Francesco Del Galdo   +9 more
wiley   +1 more source

Stroke in the Young: A Case of CNS Vasculitis Secondary to Systemic Lupus Erythematosus

Clinical Case Reports, Volume 13, Issue 7, July 2025.
ABSTRACT Systemic lupus erythematosus (SLE) is an enigmatic autoimmune disease with a varied presentation that carries with it an increased risk for many potentially life‐threatening problems. When compared with the general population, the relative risk of ischemic stroke in SLE is more than doubled.
John Badir, Justin Thorson, Emily Barr, Tamra Ranasinghe   +3 more
wiley   +1 more source

Atypical Multiple Sclerosis Overlapping Features of Neuromyelitis Optica Spectrum Disorders (NMOSD)

Clinical Case Reports, Volume 13, Issue 7, July 2025.
ABSTRACT We aim to discuss the importance of accurately diagnosing atypical inflammatory demyelinating diseases (IDD), particularly neuromyelitis optica spectrum disorders (NMOSD), which exhibit similar pathological characteristics to multiple sclerosis (MS). An accurate diagnosis is crucial as the disease‐modifying treatments (DMTs) used for MS can be
Sepideh Paybast, Ali Emami, Nasim Rezaeimanesh, Abdorreza Naser Moghadasi   +3 more
wiley   +1 more source

Expanding the Phenotypic Spectrum of Methylenetetrahydrofolate Reductase (MTHFR) Deficiency in Childhood: A Case Series

Clinical Case Reports, Volume 13, Issue 7, July 2025.
ABSTRACT Methylenetetrahydrofolate reductase (MTHFR) deficiency is a rare inborn error of folate metabolism. A number of phenotypic findings have been identified to date, and we hereby wish to expand its phenotype based on our Irish experience of the condition.
Eimear Loftus, Zaineb Elbishari, Patricia Fitzsimons, Caoimhe Howard, Yusra Sheikh, Bryan Lynch, Ellen Crushell, Ina Knerr   +7 more
wiley   +1 more source

Assessing serum anti-nuclear antibodies HEp-2 patterns in synucleinopathies

Immunity & Ageing
This study investigates the presence of antinuclear antibodies (ANA) in three primary synucleinopathies – Parkinson’s disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB), compared to healthy controls.
Jonas Folke, Marie Skougaard, Trine-Line Korsholm, Anne-Line Strange Laursen, Lisette Salvesen, Anne-Mette Hejl, Sara Bech, Annemette Løkkegaard, Tomasz Brudek, Sisse Bolm Ditlev, Susana Aznar   +10 more
doaj   +1 more source

Clinical Images: Interstitial lung disease in Sjögren disease in association with systemic sclerosis

ACR Open Rheumatology, Volume 7, Issue 7, July 2025.
Brandon M. Law, Laura J. Yockey, Eman Seyal, William C. Faquin   +3 more
wiley   +1 more source