Antinuclear antibody profiling in uveitis [PDF]
_Editor,_ Antinuclear antibodies (ANA) are antibodies directed against a variety of nuclear antigens and are detected in patients with autoimmune diseases. Antinuclear antibodies (ANA) profiling is relevant for diagnostic purposes in various diseases, including systemic lupus erythematosus (SLE), Sj€ogren syndrome and systemic sclerosis (Smeenk et ...
Josianne C. ten Berge +3 more
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Post-Partum Pituitary Insufficiency and Livedo Reticularis Presenting a Diagnostic Challenge in a Resource Limited Setting in Tanzania: A Case Report, Clinical Discussion and Brief Review of Existing Literature. [PDF]
Pituitary disorders following pregnancy are an important yet under reported clinical entity in the developing world. Conversely, post partum panhypopituitarism has a more devastating impact on women in such settings due to high fertility rates, poor ...
A Cénac +27 more
core +3 more sources
Eosinophilic fasciitis (Shulman's disease): review and comparative evaluation of seven patients. [PDF]
OBJECTIVES: Eosinophilic fasciitis (EF) was described in 1974 by Shulman as a rare fibrosing connective tissue disease of unknown etiology. An undetermined trigger is thought to lead to the degranulation of eosinophils that interact with fibroblasts and
Cimbron, M +3 more
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The presence of abnormal levels of autoantibodies to intracellular antigens is a hallmark of systemic connective tissue disease. The indirect immunofluorescence assay is the most commonly used routine test for the detection of antinuclear antibodies.
openaire +2 more sources
ANTINUCLEAR ANTIBODIES IN RABBIT ANTISERA [PDF]
Antinuclear antibodies were detected by immunofluorescence in most sera from rabbits immunized with whole human serum emulsified in Freund's complete adjuvant. Four of 14 sera from rabbits immunized with Cohn fractions III, IV-1, or IV-4 also gave positive nuclear fluorescence with human leukocyte nuclei.
John H. Vaughan, Eugene V. Barnett
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Autoantibody profiles and their association with blood eosinophils in asthma and COPD
Background: Autoimmune involvement in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD) has been proposed, and autoantibodies are a hallmark of autoimmunity.
Koji Tamai +10 more
doaj +1 more source
Pauci-immune glomerulonephritis in individuals with disease associated with levamisole-adulterated cocaine: a series of 4 cases. [PDF]
Exposure to levamisole-adulterated cocaine can induce a distinct clinical syndrome characterized by retiform purpura and/or agranulocytosis accompanied by an unusual constellation of serologic abnormalities including antiphospholipid antibodies, lupus ...
Butcher, Brad +6 more
core +2 more sources
Endoscopic and clinical evaluation of treatment and prognosis of Cronkhite-Canada syndrome: a Japanese nationwide survey. [PDF]
BackgroundFirst reported in 1955, Cronkhite-Canada syndrome (CCS), a rare syndrome characterized by ectodermal abnormalities and inflammatory changes of the gastrointestinal tract mucosa, has been associated with a poor prognosis and life-threatening ...
Hibi, Toshifumi +8 more
core +1 more source
Objectives Evaluate the efficacy and safety of baricitinib in paediatric patients with active JIA‐U or chronic anterior ANA‐positive uveitis, who had an inadequate response to MTX or bDMARDs. Methods JUVE‐BRIGHT was an open‐label, active‐controlled, Phase‐3 multicentre trial which utilized a novel design, including 1:1 randomization to an active ...
Athimalaipet V. Ramanan +7 more
wiley +1 more source
Detection of specific antinuclear antibodies is very important in term of diagnosis, prognosis and management of patients with systemic autoimmune rheumatic diseases.
Yuan Dandan +8 more
doaj +1 more source

