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Monoclonal Antibodies as Tools to Combat Fungal Infections [PDF]

Journal of Fungi, 2020
Antibodies represent an important element in the adaptive immune response and a major tool to eliminate microbial pathogens. For many bacterial and viral infections, efficient vaccines exist, but not for fungal pathogens. For a long time, antibodies have
Sebastian Ulrich, Frank Ebel
doaj   +4 more sources

Immunotherapy against Systemic Fungal Infections Based on Monoclonal Antibodies [PDF]

Journal of Fungi, 2020
: The increasing incidence in systemic fungal infections in humans has increased focus for the development of fungal vaccines and use of monoclonal antibodies.
Camila Boniche, Suélen Andreia Rossi, Brenda Kischkel, Filipe Vieira Barbalho, Ágata Nogueira D’Aurea Moura, Joshua D. Nosanchuk, Luiz R. Travassos, Carlos Pelleschi Taborda   +7 more
doaj   +4 more sources

Antibodies against glycolipids enhance antifungal activity of macrophages and reduce fungal burden after infection with Paracoccidioides brasiliensis

Frontiers in Microbiology, 2016
Paracoccidioidomycosis is a fungal disease endemic in Latin America. Polyclonal antibodies to acidic glycosphingolipids (GSLs) from Paracoccidioides brasiliensis opsonized yeast forms in vitro increasing phagocytosis and reduced the fungal burden of ...
Renata Amelia eBueno, Luciana eTomaz, Julian Esteban eMuñoz, Cassia eSilva, Joshua D Nosanchuk, Marcia Ribeiro Pinto, Luiz R Travassos, Carlos Pelleschi Taborda   +7 more
doaj   +2 more sources

Antibodies to Combat Fungal Infections: Development Strategies and Progress

Microorganisms, 2023
The finding that some mAbs are antifungal suggests that antibody immunity may play a key role in the defense of the host against mycotic infections. The discovery of antibodies that guard against fungi is a significant advancement because it gives rise ...
Ali A. Rabaan, Amal H. Alfaraj, Amer Alshengeti, Abdulsalam Alawfi, Sara Alwarthan, Mashael Alhajri, Amal H. Al-Najjar, Mona A. Al Fares, Mustafa A. Najim, Souad A. Almuthree, Sultan T. AlShurbaji, Fadwa S. Alofi, Bashayer M. AlShehail, Buthina AlYuosof, Ahlam Alynbiawi, Suha A. Alzayer, Nawal Al Kaabi, Wesam A. Abduljabbar, Zakiyah A. Bukhary, Ahmed S. Bueid   +19 more
doaj   +3 more sources

Protection by anti-beta-glucan antibodies is associated with restricted beta-1,3 glucan binding specificity and inhibition of fungal growth and adherence. [PDF]

PLoS ONE, 2009
Anti-beta-glucan antibodies elicited by a laminarin-conjugate vaccine confer cross-protection to mice challenged with major fungal pathogens such as Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans.
Antonella Torosantucci, Paola Chiani, Carla Bromuro, Flavia De Bernardis, Angelina S Palma, Yan Liu, Giuseppina Mignogna, Bruno Maras, Marisa Colone, Annarita Stringaro, Silvia Zamboni, Ten Feizi, Antonio Cassone   +12 more
doaj   +2 more sources

Antibodies targeting Candida albicans Als3 and Hyr1 antigens protect neonatal mice from candidiasis

Frontiers in Immunology, 2022
Pre-term infants in neonatal intensive care units are vulnerable to fungal sepsis. In this patient population, Candida albicans remains the predominant fungal pathogen causing high morbidity and mortality, despite antifungal therapy.
Shakti Singh, Sunna Nabeela, Ashley Barbarino, Ashraf S. Ibrahim, Ashraf S. Ibrahim, Priya Uppuluri, Priya Uppuluri   +6 more
doaj   +2 more sources

Fungal infections following treatment with monoclonal antibodies and other immunomodulatory therapies

Revista Iberoamericana de Micología, 2020
Tumor necrosis factor (TNF) is a proinflammatory cytokine involved in a wide range of important physiologic processes and has a pathologic role in some diseases. TNF antagonists (infliximab, adalimumab, etanercept) are effective in treating inflammatory conditions.
Francisco Javier, Candel, Marina, Peñuelas, Carolina, Tabares, Carolina, Garcia-Vidal, Mayra, Matesanz, Miguel, Salavert, Pilar, Rivas, Javier, Pemán   +7 more
semanticscholar   +5 more sources

The Role of B-Cells and Antibodies against Candida Vaccine Antigens in Invasive Candidiasis

Vaccines, 2021
Systemic candidiasis is an invasive fungal infection caused by members of the genus Candida. The recent emergence of antifungal drug resistance and increased incidences of infections caused by non-albicans Candida species merit the need for developing ...
Manisha Shukla, Pankaj Chandley, Soma Rohatgi   +2 more
doaj   +2 more sources

Fungal-specific IgG responses in allergic conjunctivitis: comparison with IgE and immunological implications [PDF]

PeerJ
Background Immunoglobulin G (IgG) is the most abundant antibody class in the bloodstream and is characterized by a long half-life compared to other immunoglobulins.
Tatsuya Mimura
doaj   +3 more sources

Targeting Aspergillus fumigatus Crf Transglycosylases With Neutralizing Antibody Is Relevant but Not Sufficient to Erase Fungal Burden in a Neutropenic Rat Model

Frontiers in Microbiology, 2019
Aspergillus fumigatus is an airborne opportunistic fungal pathogen responsible for severe infections. Among them, invasive pulmonary aspergillosis has become a major concern as mortality rates exceed 50% in immunocompromised hosts.
David Chauvin, David Chauvin, Michael Hust, Mark Schütte, Adélaïde Chesnay, Adélaïde Chesnay, Adélaïde Chesnay, Christelle Parent, Christelle Parent, Gustavo Marçal Schmidt Garcia Moreira, Javier Arroyo, Ana Belén Sanz, Martine Pugnière, Pierre Martineau, Jacques Chandenier, Jacques Chandenier, Jacques Chandenier, Nathalie Heuzé-Vourc’h, Nathalie Heuzé-Vourc’h, Guillaume Desoubeaux, Guillaume Desoubeaux, Guillaume Desoubeaux   +21 more
doaj   +2 more sources