Results 11 to 20 of about 2,168,435 (342)

Single human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasis

Nature Communications, 2018
Late diagnosis and ineffective treatment of fungal infections lead to high mortality. Here, Rudkin et al. generate anti-Candida human monoclonal antibodies with diagnostic and therapeutic potential, by expressing recombinant antibodies from genes cloned ...
Fiona M. Rudkin, Ingrida Raziunaite, Hillary Workman, Sosthene Essono, Rodrigo Belmonte, Donna M. MacCallum, Elizabeth M. Johnson, Lisete M. Silva, Angelina S. Palma, Ten Feizi, Allan Jensen, Lars P. Erwig, Neil A. R. Gow   +12 more
doaj   +2 more sources

Immunoglobulin G3 blocking antibodies to the fungal pathogen Cryptococcus neoformans. [PDF]

The Journal of experimental medicine, 1996
Vaccination and infection can elicit protective and nonprotective antibodies to the fungus Cryptococcus neoformans in mice. The effect of nonprotective antibodies on host defense is unknown. In this study we used mixtures of protective and nonprotective monoclonal antibodies (mAbs) to determine if nonprotective mAbs blocked the activity of the ...
G, Nussbaum, R, Yuan, A, Casadevall, M D, Scharff   +3 more
openaire   +3 more sources

Fungal infection in neural tissue of patients with amyotrophic lateral sclerosis

Neurobiology of Disease, 2017
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease and the main cause of motor neuron pathology. The etiology of the disease remains unknown, and no effective therapy exists to halt the disease or improve the quality of life ...
Ruth Alonso, Diana Pisa, Ana M. Fernández-Fernández, Alberto Rábano, Luis Carrasco   +4 more
doaj   +2 more sources

Fungal iron availability during deep seated candidiasis is defined by a complex interplay involving systemic and local events [PDF]

, 2013
Peer reviewedPublisher ...
A Matusch, A Mencacci, AE Armitage, Alistair J. P. Brown, AM Thomson, Andrea Raab, AS Ibrahim, B Spellberg, BD Corbin, CH Park, CJ Barelle, CM Lloyd, CP Smith, D Kaloriti, D Suckau, Dagmar S. Urgast, David Stead, DD Haines, DH Navarathna, DM Barry, DM MacCallum, DM MacCallum, Donna M. MacCallum, DS Urgast, ED Weinberg, EE Johnson, EH Seeley, G Kovtunovych, GD Brown, GO Latunde-Dada, H Drakesmith, H Haas, H Wang, HI Feldman, IV Ene, JC Sardi, JF McManus, JM El HageChahine, Joanna Potrykus, Jörg Feldmann, M Ogawa, MC Lorenz, MD Maines, MI Hood, MJ Marakalala, ML Pendrak, N Ramanan, N Van Rooijen, NA Gow, Nico van Rooijen, P Heymann, Q Qian, R Santos, RJ Ward, RS Almeida, S Shimma, SA Knight, Scott G. Filler, T Roemer, W Fonzi, WH Jung   +60 more
core   +15 more sources

Human gut mycobiota tune immunity via CARD9-dependent induction of anti-fungal IgG antibodies.

Cell, 2021
Antibodies mediate natural and vaccine-induced immunity against viral and bacterial pathogens, whereas fungi represent a widespread kingdom of pathogenic species for which neither vaccine nor neutralizing antibody therapies are clinically available. Here,
Itai Doron, Irina Leonardi, Xin V. Li, William D. Fiers, Alexa Semon, Meghan Bialt-DeCelie, M. Migaud, I. H. Gao, Woan-Yu Lin, Takato Kusakabe, A. Puel, I. Iliev   +11 more
semanticscholar   +1 more source

Mycobiota-induced IgA antibodies regulate fungal commensalism in the gut and are dysregulated in Crohn’s Disease

Nature Microbiology, 2021
Secretory immunoglobulin A (sIgA) plays an important role in gut barrier protection by shaping the resident microbiota community, restricting the growth of bacterial pathogens and enhancing host protective immunity via immunological exclusion.
Itai Doron, Marissa Mesko, Xin V. Li, Takato Kusakabe, Irina Leonardi, D. Shaw, William D. Fiers, Woan-Yu Lin, Meghan Bialt-DeCelie, E. Román, R. Longman, J. Pla, P. Wilson, I. Iliev   +13 more
semanticscholar   +1 more source

ASCA-related antibodies in the blood sera of healthy donors and patients with colorectal cancer: characterization with oligosaccharides related to Saccharomyces cerevisiae mannan

Frontiers in Molecular Biosciences, 2023
Mannans are polysaccharide antigens expressed on the cell wall of different fungal species including Saccharomyces cerevisiae and Candida spp. These fungi are components of the normal intestinal microflora, and the presence of antibodies to fungal ...
Vadim B. Krylov, Vadim B. Krylov, Anton N. Kuznetsov, Alina V. Polyanskaya, Pavel V. Tsarapaev, Pavel V. Tsarapaev, Dmitry V. Yashunsky, Nikolay E. Kushlinskii, Nikolay E. Nifantiev   +8 more
doaj   +1 more source

Immunoglobulins at the interface of the gut mycobiota and anti-fungal immunity.

Seminars in Immunology, 2023
The dynamic and complex community of microbes that colonizes the intestines is composed of bacteria, fungi, and viruses. At the mucosal surfaces, immunoglobulins play a key role in protection against bacterial and fungal pathogens, and their toxins ...
Itai Doron, Takato Kusakabe, I. Iliev
semanticscholar   +1 more source

Antibody-Guided Alpha Radiation Effectively Damages Fungal Biofilms [PDF]

Antimicrobial Agents and Chemotherapy, 2006
ABSTRACT The use of indwelling medical devices—pacemakers, prosthetic joints, catheters—is rapidly growing and is often complicated by infections with biofilm-forming microbes that are resistant to antimicrobial agents and host defense mechanisms.
L R, Martinez, R A, Bryan, C, Apostolidis, A, Morgenstern, A, Casadevall, E, Dadachova   +5 more
openaire   +2 more sources

High mortality co-infections of COVID-19 patients: mucormycosis and other fungal infections

Discoveries, 2021
Severe COVID-19 disease is associated with an increase in pro-inflammatory markers, such as IL-1, IL-6, and tumor necrosis alpha, less CD4 interferon-gamma expression, and fewer CD4 and CD8 cells, which increase the susceptibility to bacterial and fungal
K. Bhatt, Arjola Agolli, M. Patel, Radhika Garimella, M. Devi, Efrain Garcia, H. Amin, Carlos Domingue, Roberto Guerra Del Castillo, M. Sanchez-Gonzalez   +9 more
semanticscholar   +1 more source