Results 1 to 10 of about 291,142 (306)

Cooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus [PDF]

Cell Reports, 2017
Summary: Drug combinations are synergistic when their combined efficacy exceeds the sum of the individual actions, but they rarely include ineffective drugs that become effective only in combination. We identified several “enabling pairs” of neutralizing
Katie A. Howell, Jennifer M. Brannan, Christopher Bryan, Andrew McNeal, Edgar Davidson, Hannah L. Turner, Hong Vu, Sergey Shulenin, Shihua He, Ana Kuehne, Andrew S. Herbert, Xiangguo Qiu, Benjamin J. Doranz, Frederick W. Holtsberg, Andrew B. Ward, John M. Dye, M. Javad Aman   +16 more
doaj   +3 more sources

Lack of protection following passive transfer of polyclonal highly functional low-dose non-neutralizing antibodies. [PDF]

PLoS ONE, 2014
Recent immune correlates analysis from the RV144 vaccine trial has renewed interest in the role of non-neutralizing antibodies in mediating protection from infection.
Anne-Sophie Dugast, Ying Chan, Michelle Hoffner, Anna Licht, Joseph Nkolola, Hualin Li, Hendrik Streeck, Todd J Suscovich, Musie Ghebremichael, Margaret E Ackerman, Dan H Barouch, Galit Alter   +11 more
doaj   +6 more sources

COVID-19: are neutralizing antibodies neutralizing enough? [PDF]

Transfusion, 2020
Kadkhoda K.
europepmc   +4 more sources

SARS-CoV-2 fusion-peptide-directed antibodies are elicited by natural infection and can mediate broad sarbecovirus neutralization [PDF]

Cell Reports
Summary: Studies have demonstrated that repeated mRNA vaccination enhances the breadth of neutralization against diverse severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. However, the development of antibodies capable of neutralizing
Alex L. Roederer, Chia Jung Li, Eunice Lim, Yi Cao, Larance Ronsard, Daniel Lingwood, David H. Canaday, Stefan Gravenstein, Alejandro B. Balazs   +8 more
doaj   +2 more sources

Antibody Response to SARS-CoV-2 among COVID-19 Confirmed Cases and Correlates with Neutralizing Assay in a Subgroup of Patients in Delhi National Capital Region, India

Vaccines, 2022
Background: The plaque reduction neutralization test (PRNT) is the gold standard to detect the neutralizing capacity of serum antibodies. Neutralizing antibodies confer protection against further infection.
Puneet Misra, Shashi Kant, Randeep Guleria, Sanjay K. Rai, Abhishek Jaiswal, Suprakash Mandal, Guruprasad R. Medigeshi, Mohammad Ahmad, Anisur Rahman, Meenu Sangral, Kapil Yadav, Mohan Bairwa, Partha Haldar, Parveen Kumar   +13 more
doaj   +1 more source

A sensitive and reproducible cell-based assay via secNanoLuc to detect neutralizing antibody against adeno-associated virus vector capsid

Molecular Therapy: Methods & Clinical Development, 2021
Most gene therapy clinical trials that systemically administered adeno-associated virus (AAV) vector enrolled only patients without anti-AAV-neutralizing antibodies.
Nemekhbayar Baatartsogt, Yuji Kashiwakura, Morisada Hayakawa, Nobuhiko Kamoshita, Takafumi Hiramoto, Hiroaki Mizukami, Tsukasa Ohmori   +6 more
doaj   +1 more source

A new strategy: identification of specific antibodies for neutralizing epitope on SARS-CoV-2 S protein by LC-MS/MS combined with immune repertoire

Molecular Biomedicine, 2022
Although the SARS-CoV-2 vaccine has been widely used worldwide, not all individuals can produce neutralization antibodies, so it is still urgent to find and prepare neutralization antibodies for COVID-19 prevention or treatment. In this study, we created
Meng Yu, Zhu Zhu, Yanqun Wang, Pingzhang Wang, Xiaodong Jia, Jie Wang, Lei Liu, Wanbing Liu, Yaqiong Zheng, Guomei Kou, Weiyan Xu, Jing Huang, Fengmin Lu, Xiajuan Zou, Shangen Zheng, Yinying Lu, Jincun Zhao, Hui Dai, Xiaoyan Qiu   +18 more
doaj   +1 more source

Dissecting the human serum antibody response to secondary dengue virus infections. [PDF]

PLoS Neglected Tropical Diseases, 2017
Dengue viruses (DENVs) are mosquito-borne flaviviruses and the causative agents of dengue fever and dengue hemorrhagic fever. As there are four serotypes of DENV (DENV1-4), people can be infected multiple times, each time with a new serotype.
Bhumi Patel, Patti Longo, Michael J Miley, Magelda Montoya, Eva Harris, Aravinda M de Silva   +5 more
doaj   +1 more source

Higher levels of neutralizing antibodies against KSHV in KS patients compared to asymptomatic individuals from Zambia. [PDF]

PLoS ONE, 2013
Kaposi sarcoma-associated herpesvirus (KSHV) is the etiologic agent for Kaposi Sarcoma (KS), the most common cancer diagnosed in HIV- infected patients.
Pankaj Kumar, Nithal Y Kuwa, Veenu Minhas, Clemence Marimo, Danielle M Shea, Chipepo Kankasa, Charles Wood   +6 more
doaj   +1 more source

Outliers Matter—Correlation between S1 IgG SARS-CoV-2 Antibodies and Neutralizing SARS-CoV-2 Antibodies

Microorganisms, 2022
Vaccination against the SARS-CoV-2 virus or infection with SARS-CoV-2 will lead to the development of IgG antibodies against the S1 protein of the SARS-CoV-2 virus.
Berthold Hocher, Anne Schönbrunn, Xin Chen, Bernhard K. Krämer, Volker von Baehr   +4 more
doaj   +1 more source