Results 1 to 10 of about 288,583 (110)

RNA polymerase II stalling promotes nucleosome occlusion and pTEFb recruitment to drive immortalization by Epstein-Barr virus [PDF]

, 2011
Epstein-Barr virus (EBV) immortalizes resting B-cells and is a key etiologic agent in the development of numerous cancers. The essential EBV-encoded protein EBNA 2 activates the viral C promoter (Cp) producing a message of ~120 kb that is differentially ...
A Bakos, A Bell, A Dey, A Lin, AI Bell, B Kempkes, B Sugden, BM Peterlin, C Lee, CD Gregory, CF Bourgeois, CH Wu, CH Wu, D Ivanov, DA Gilchrist, DC Hargreaves, DS Gilmour, DS Gilmour, DY Wu, DY Wu, E Johannsen, E Klein, EA Abbate, G Kelly, G Laux, H Gross, H Kirby, Helen M. Webb, I Tempera, J You, JH Yik, JI Cohen, K Fujinaga, KD Robertson, KD Robertson, L Waltzer, L Wang, M Ottinger, M Woisetschlaeger, M Woisetschlaeger, Michelle J. West, MJ West, MK Jang, N Alazard, N Kaplan, NA Brown, NF Marshall, NP Gomes, P Filippakopoulos, Paul M. Lieberman, R Tierney, Richard D. Palermo, S Egloff, S Egloff, S Swaminathan, SH Chao, SJ Bark-Jones, SR Grossman, SY Wu, T Fujita, T Fujita, T Henkel, T Wada, T Wada, U Zimber-Strobl, VT Nguyen, W Lucchesi, W Yue, W Yue, W Yue, W Zhu, X Tong, X Tong, X Tong, YK Kim, Z Yang   +75 more
core   +26 more sources

Blocking entry of hepatitis B and D viruses to hepatocytes as a novel immunotherapy for treating chronic infections [PDF]

, 2021
Background. Chronic hepatitis B and D virus (HBV/HDV) infections can cause cancer. Current HBV therapy using nucleoside analogues (NAs) is life-long and reduces but does not eliminate the risk of cancer.
Ahlén, G, Frelin, L, Jagya, N, Johansson, M, Maravelia, P, Meuleman, Philip, Ni, Y, Pasetto, A, Pater, L, Pérez, NC, Sällberg, M, Urban, S, Verch, G, Verhoye, Lieven   +13 more
core   +1 more source

Unbiased interrogation of memory B cells from convalescent COVID-19 patients reveals a broad antiviral humoral response targeting SARS-CoV-2 antigens beyond the spike protein

Vaccine: X, 2021
Patients who recover from SARS-CoV-2 infections produce antibodies and antigen-specific T cells against multiple viral proteins. Here, an unbiased interrogation of the anti-viral memory B cell repertoire of convalescent patients has been performed by ...
Jillian M. DiMuzio, Baron C. Heimbach, Raymond J. Howanski, John P. Dowling, Nirja B. Patel, Noeleya Henriquez, Chris Nicolescu, Mitchell Nath, Antonio Polley, Jamie L. Bingaman, Todd Smith, Benjamin C. Harman, Matthew K. Robinson, Michael J. Morin, Pavel A. Nikitin   +14 more
doaj   +1 more source

Behaviour of non-donor specific antibodies during rapid re-synthesis of donor specific HLA antibodies after antibody incompatible renal transplantation [PDF]

, 2013
Background: HLA directed antibodies play an important role in acute and chronic allograft rejection. During viral infection of a patient with HLA antibodies, the HLA antibody levels may rise even though there is no new immunization with antigen ...
Briggs, David, Dr., Daga, Sunil, Hamer, Rizwan, Higgins, Rob, Imray, C. (Chris), Kashi, Habib, Krishnan, Nithya S., Lam, F. T., Lowe, David Philip, Raymond, Neil T., Tan, Lam Chin, Zehnder, Daniel   +11 more
core   +8 more sources

An influenza HA stalk reactive polymeric IgA antibody exhibits anti-viral function regulated by binary interaction between HA and the antibody.

PLoS ONE, 2021
IgA antibodies, which are secreted onto the mucosal surface as secretory IgA antibodies (SIgAs), play an important role in preventing influenza virus infection.
Kaori Sano, Shinji Saito, Tadaki Suzuki, Osamu Kotani, Akira Ainai, Elly van Riet, Koshiro Tabata, Kumpei Saito, Yoshimasa Takahashi, Masaru Yokoyama, Hironori Sato, Takahiro Maruno, Kaede Usami, Susumu Uchiyama, Kiyoko Ogawa-Goto, Hideki Hasegawa   +15 more
doaj   +1 more source

Endogenously Produced SARS-CoV-2 Specific IgG Antibodies May Have a Limited Impact on Clearing Nasal Shedding of Virus during Primary Infection in Humans

Viruses, 2021
While SARS-CoV-2 specific neutralizing antibodies have been developed for therapeutic purposes, the specific viral triggers that drive the generation of SARS-CoV-2 specific IgG and IgM antibodies remain only partially characterized.
Shuyi Yang, Keith R. Jerome, Alexander L. Greninger, Joshua T. Schiffer, Ashish Goyal   +4 more
doaj   +1 more source

Mechanisms of hemagglutinin targeted influenza virus neutralization. [PDF]

PLoS ONE, 2013
Human monoclonal antibodies have been identified which neutralize broad spectra of influenza A or B viruses. Here, we dissect the mechanisms by which such antibodies interfere with infectivity.
Boerries Brandenburg, Wouter Koudstaal, Jaap Goudsmit, Vincent Klaren, Chan Tang, Miriam V Bujny, Hans J W M Korse, Ted Kwaks, Jason J Otterstrom, Jarek Juraszek, Antoine M van Oijen, Ronald Vogels, Robert H E Friesen   +12 more
doaj   +1 more source

Detection of Anti-Nucleocapsid Antibody in COVID-19 Patients in Bangladesh Is not Correlated with Previous Dengue Infection

Pathogens, 2021
Background: The assessment of antibody responses to severe acute respiratory syndrome coronavirus-2 is potentially confounded by exposures to flaviviruses. The aims of the present research were to determine whether anti-dengue antibodies affect the viral
Simon D. Lytton, Mahmuda Yeasmin, Asish Kumar Ghosh, Md. Rakibul Hassan Bulbul, Md. Maruf Ahmed Molla, Martha Herr, Helmut Duchmann, Md. Mohiuddin Sharif, Tasnim Nafisa, Md. Robed Amin, Nur Hosen, Md. Tanvir Rahman, Sumaiya Islam, Alimul Islam, Abul Khair Mohammad Shamsuzzaman   +14 more
doaj   +1 more source

Complete mapping of viral escape from neutralizing antibodies. [PDF]

PLoS Pathogens, 2017
Identifying viral mutations that confer escape from antibodies is crucial for understanding the interplay between immunity and viral evolution. We describe a high-throughput approach to quantify the selection that monoclonal antibodies exert on all ...
Michael B Doud, Scott E Hensley, Jesse D Bloom   +2 more
doaj   +1 more source

Combination of rRT-PCR and Anti-Nucleocapsid/Anti-Spike Antibodies to Characterize Specimens with Very Low Viral SARs-CoV-2 Load: A Real-Life Experience

Microorganisms, 2021
The objective of the present study was to evaluate the true positivity among people, whose results of initial testing of nasopharyngeal swabs (NPS) showed a very low viral load of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Zoe Florou, Meropi Zigra, Philippos Kartalidis, Katerina Tsilipounidaki, Georgia Papadamou, Aikaterini Belia, George C. Fthenakis, Efthymia Petinaki   +7 more
doaj   +1 more source