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P21‐Activated Kinase 2 as a Novel Target for Ventricular Tachyarrhythmias Associated with Cardiac Adrenergic Stress and Hypertrophy

Advanced Science, EarlyView.
Ca2+/calmodulin‐dependent kinase II (CaMKII) activation is likely driven by oxidative stress, particularly excessive reactive oxygen species (ROS) production. This study identifies P21‐activated kinase 2 (Pak2) as a novel regulator of ROS‐induced CaMKII activation and abnormal Ca2⁺ dynamics in acute adrenergic and chronic pressure‐overload stressed ...
Tao Li, Ting Liu, Yan Wang, Yangpeng Li, Leiying Liu, James Bae, Yu He, Xian Luo, Zhu Liu, Tangting Chen, Xianhong Ou, Dan Zhang, Huan Lan, Juyi Wan, Yan Wei, Fang Zhao, Xin Wang, Tao Li, Christopher L.‐H. Huang, Chunxiang Zhang, Ming Lei, Xiaoqiu Tan   +21 more
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Histocompatibility Types and Viral Antibodies

Archives of Neurology, 1976
Serum neutralizing (Nt) antibodies to herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), and histocompatibility (HL-A) types, were determined in multiple sclerosis (MS) patients and in control subjects. Titers of Nt antibodies to HSV-1 and to HSV-2 were increased among subjects bearing HL-A3 or HL-A7 or both, whether they suffered from MS or not ...
James R. Lehrich, Barry G. W. Arnason
openaire   +3 more sources

Human Antibodies for Viral Infections

Annual Review of Immunology, 2022
Antibodies have been used to prevent or treat viral infections since the nineteenth century, but the full potential to use passive immunization for infectious diseases has yet to be realized. The advent of efficient methods for isolating broad and potently neutralizing human monoclonal antibodies is enabling us to develop antibodies with unprecedented
openaire   +2 more sources

Viral infections and antiphospholipid antibodies

Seminars in Arthritis and Rheumatism, 2002
To study the relationship between viral infections and the induction of antiphospholipid (aPL) antibodies.We reviewed the medical literature from 1968 until 2000 using MEDLINE and the key words virus, infection, antiphospholipid, and anticardiolipin.Anticardiolipin antibodies and/or lupus anticoagulant were associated with a number of viral infections,
Imad Uthman, Azzudin E. Gharavi
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Antibodies in Viral Infection [PDF]

, 2001
Antibody interactions with rhinovirus lessons for mechanisms of neutralization and the role of immunity in viral evolution.- Structural studies on antibody with viruses.- Shape and electrostatic complementarity at viral antigen-antibody complexes.- Structural studies on viral escape from antibody neutralization.- Affinity, complementarity ...
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Viral antibodies in maternal and cord sera [PDF]

Medical Microbiology and Immunology, 1983
Viral antibodies were determined in paired maternal and cord blood sera of 258 consecutive deliveries. Antibodies to Epstein-Barr virus (EBV), cytomegalovirus (CMV), herpes simplex type 1 (HSV-1), adenovirus (ADV), and varicella zoster (VZV) were tested by indirect immunofluorescence and to rubella (RUB) by hemagglutination inhibition.
R Gurewitz, Michaela Modan, T Gotlieb-Stematsky, A Fogel, S Leventon-Kriss, V Insler, Y Sayar, I Meron   +7 more
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Human monoclonal antibodies to viral peptides

Human Antibodies, 1997
A new approach to the developing of human monoclonal antibodies to viral peptides is described. The method is based on the positive selection of B cells specific to viral peptides from normal human tissues. To isolate B cells bearing immunoglobulin receptors specific to viral epitopes magnetic beads coated by viral peptides were used.
Anders Rosén, Tatiana Borisova, Ekaterina Sidorova, Lilya Lyakisheva   +3 more
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Viral antibodies in mothers of defective children

Teratology, 1972
AbstractIn the years 1964‐66, 338 newborns with a total of 379 gross malformations of the central nervous system and matched‐pair controls were reported to the Finnish Register of Congenital Malformations. Blood samples and detailed maternal histories were obtained from 162 mothers of defective children and their respective controls during the first 2,
Kaisa Lapinleimu, Olli Koskimies, Lauri Saxén, Kari Cantell   +3 more
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Viral antibodies in twins with multiple sclerosis [PDF]

Neurology, 1985
Viral antibodies to measles, rubella, corona, vaccinia, and mumps viruses in serum and CSF (and to Epstein-Barr virus in serum only) were studied in 24 twin pairs, both discordant and concordant for clinical MS. In pairs, CSF antibody titers for rubella in MS monozygotic and dizygotic twins and for vaccinia in dizygotic twins were higher than for ...
Dale E. McFarlin, C. Shekarchi, J. L. Woyciechowska, J. Dambrozia, William C. Wallen, Henry F. McFarland, JohnL. Sever, P. Leinikki   +7 more
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VIRAL ANTIBODIES IN COYOTES FROM CALIFORNIA

Journal of Wildlife Diseases, 1998
Prevalence of antibodies against canine parvovirus (CPV), canine distemper virus (CDV), and canine adenovirus type 1 (CAV) were determined among 152 coyotes (Canis latrans) at the Naval Petroleum Reserves (NPRC; California, USA) from 1985 to 1990. Overall prevalence of antibodies to CPV, CDV, and CAV was 66%, 37%, and 68%, respectively.
Kristie L. Hammer, Brian L. Cypher, Jerry H. Scrivner, Thomas P. O'Farrell   +3 more
openaire   +3 more sources