Results 221 to 230 of about 950,836 (305)

Nanoparticle-Based Antiviral Vaccines for Chickens: Recent Advances and Future Perspectives. [PDF]

Transbound Emerg Dis
Ding P, Xia L, Dong S.
europepmc   +1 more source

DKK3 Initially Preserves Acinar Integrity Through MEK‐Fos Signaling, but Later Switches to an Oncogenic Role in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic cancer, the protein DKK3 is found to play a complex role: it initially slows early tumor growth but later promotes tumor aggressiveness. DKK3 expression evolves during progression and drives cancer severity by orchestrating cellular and molecular signaling pathways.
Dharini Srinivasan, Elodie Roger, Lukas Perkhofer, Eleni Zimmer, Thomas F.E. Barth, Julia P. Mosler, Anna Härle, Stephanie E. Weissinger, Nadine T. Gaisa, Peter Möller, Nico Fischer, Chantal Allgöwer, J.‐Matthias Löhr, Dirk Grimm, Thomas Seufferlein, Stefan Liebau, Ninel Azoitei, Michael K. Melzer, Frank Arnold, Johann Gout, Alexander Kleger   +20 more
wiley   +1 more source

HTATSF1 regulates innate antiviral immune response by orchestrating TRAF3-IRF3 and TRAF6-NF-κB pathways. [PDF]

Cell Insight
Zeng JQ, Ruan ZL, Zhang Q, Yi XM, Chen YD, Hu MM, Li S.   +6 more
europepmc   +1 more source

Single‐Cell RNA Sequencing of Retina Reveals Nna1 Upregulation in Myopic Diabetic Retinopathy as a Protective Factor Against Diabetic Damage

Advanced Science, EarlyView.
This study investigates a schematic overview of the mechanistic pathways. The relationship between myopia and DR has long been of clinical interest. In diabetic mice, Nna1 expression is downregulated, whereas in diabetic mice with FDM, Nna1 expression is upregulated–particularly in Müller cells–accompanied by decreased vascular endothelial growth ...
Lihui Xie, Yingjun Cai, Bolin Chen, Bowen Li, Jing Zou, Huizhuo Xu   +5 more
wiley   +1 more source

Polyfunctional antibodies in viral disease

Viral diseases still cause major consequences to our health, society and the global economy, despite the development of a multitude of vaccines and treatments. Viruses such as the human immunodeficiency virus-1 (HIV-1), respiratory syncytial virus (RSV) and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause mortality and morbidity ...
openaire   +2 more sources

Anti-SARS-CoV-2 antibodies from severe COVID-19 individuals or S2 immunizations do not worsen disease in hamsters. [PDF]

Commun Biol
Pedreño-López N, Tarrés-Freixas F, Usai C, Raïch-Regué D, Benet S, Ainsua-Enrich E, Carabelli J, Pradenas E, Ávila-Nieto C, Roca N, Cantero G, Pérez M, Rodríguez de la Concepción ML, Matilla M, Revollo B, Hernández A, Abad-Capa J, Mothe B, Moltó J, Mateu L, Massanella M, Izquierdo-Useros N, Blanco J, Clotet B, Segalés J, Vergara-Alert J, Carrillo J.   +26 more
europepmc   +1 more source

Hippocampal Chandelier Cells Modulate Seizure Susceptibility and Severity

Advanced Science, EarlyView.
The axon initial segment (AIS), crucial for action potential initiation, serves as a prime locus for controlling network activity. Chandelier Cells (ChCs), evolved in the mammals, intricately target AISs, acting as gatekeepers for neuronal firing. Diminishing ChC input makes animals more prone to developing seizures, whereas fortifying this connection ...
Yang Li, Jifeng Tian, Jiafan Wei, Qianyun Wang, Jiaxu Ge, Jianguang Ni, Jiangteng Lu, Yilin Tai   +7 more
wiley   +1 more source

Impact of previous SARS-CoV-2 infection on the severity of respiratory syncytial virus infection in hospitalized children. [PDF]

Sci Rep
Poniedziałek B, Rozwadowski M, Zabłocka K, Jackowska T, Rzymski P.   +4 more
europepmc   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

PHR‐Mediated Pi Starvation Response Mobile Messenger RNAs Represent Noncoding Transcripts in Recipient Tissues

Advanced Science, EarlyView.
Mobile messenger RNAs (mRNAs) can travel long distances, serving as systemic signals that participate in plant growth and stress acclimation. This work determines that PHR proteins mediate the Pi starvation response (PSR)‐specific long‐distance transport of mRNAs and that these PSR‐specific mobile mRNAs represent noncoding transcripts in recipient ...
Weiguo Dong, Shuman Wang, Chao Liu, Lulu Qiao, Kai Liu, Qiongli Jin, Xiaorong Mo, Xingxing Shen, Keke Yi, Zhiye Wang   +9 more
wiley   +1 more source