Results 1 to 10 of about 275,929 (307)

i-shaped antibody engineering enables conformational tuning of biotherapeutic receptor agonists [PDF]

Nature Communications
The ability to leverage antibodies to agonize disease relevant biological pathways has tremendous potential for clinical investigation. Yet while antibodies have been successful as antagonists, immune mediators, and targeting agents, they are not readily
Matthew G. Romei, Brandon Leonard, Zachary B. Katz, Daniel Le, Yanli Yang, Eric S. Day, Christopher W. Koo, Preeti Sharma, Jack Bevers III, Ingrid Kim, Huiguang Dai, Farzam Farahi, May Lin, Andrey S. Shaw, Gerald Nakamura, Jonathan T. Sockolosky, Greg A. Lazar   +16 more
doaj   +3 more sources

Engineering antibody therapeutics

Current Opinion in Structural Biology, 2016
The successful introduction of antibody-based protein therapeutics into the arsenal of treatments for patients has within a few decades fostered intense innovation in the production and engineering of antibodies. Reviewed here are the methods currently used to produce antibodies along with how our knowledge of the structural and functional ...
Chiu, Mark L, Gilliland, Gary L
openaire   +3 more sources

Antibody Engineering for the Development of Therapeutic Antibodies

Molecules and Cells, 2005
Therapeutic antibodies represent one of the fastest growing areas of the pharmaceutical industry. There are currently 19 monoclonal antibodies in the market that have been approved by the FDA and over 150 in clinical developments. Driven by innovation and technological developments, therapeutic antibodies are the second largest biopharmaceutical ...
Sang Jick, Kim, Youngwoo, Park, Hyo Jeong, Hong   +2 more
exaly   +3 more sources

A seroepidemiological survey of adenovirus type 7 circulation among healthy adults in China and in Sierra Leone, West Africa

Frontiers in Public Health, 2023
Adenovirus type 7 (HAdV7) is one of the most pathogenic human adenoviruses (HAdVs) and can cause severe illness and even death, particularly in people with weakened immune systems.
Busen Wang, Jianhua Li, Shipo Wu, Yudong Wang, Yi Chen, Yanfang Zhai, Xiaohong Song, Zhenghao Zhao, Zhe Zhang, Jinlong Zhang, Rui Yu, Lihua Hou, Wei Chen   +12 more
doaj   +1 more source

Screening of potential vaccine candidates against pathogenic Brucella spp. using compositive reverse vaccinology

Veterinary Research, 2021
Brucella spp. are Gram-negative, facultative intracellular bacteria that cause brucellosis in humans and various animals. The threat of brucellosis has increased, yet currently available live attenuated vaccines still have drawbacks.
Xiaodong Zai, Ying Yin, Fengyu Guo, Qiaoling Yang, Ruihua Li, Yaohui Li, Jun Zhang, Junjie Xu, Wei Chen   +8 more
doaj   +1 more source

A Rift Valley fever mRNA vaccine elicits strong immune responses in mice and rhesus macaques

npj Vaccines, 2023
Rift Valley fever virus (RVFV) is listed as a priority pathogen by the World Health Organization (WHO) because it causes serious and fatal disease in humans, and there are currently no effective countermeasures.
Ting Bian, Meng Hao, Xiaofan Zhao, Chuanyi Zhao, Gang Luo, Zhendong Zhang, Guangcheng Fu, Lu Yang, Yi Chen, Yudong Wang, Changming Yu, Yilong Yang, Jianmin Li, Wei Chen   +13 more
doaj   +1 more source

A Bivalent COVID-19 Vaccine Based on Alpha and Beta Variants Elicits Potent and Broad Immune Responses in Mice against SARS-CoV-2 Variants

Vaccines, 2022
With the emergence and rapid spread of new pandemic variants, especially variants of concern (VOCs), the development of next-generation vaccines with broad-spectrum neutralizing activities is of great importance.
Rui Wang, Chunyun Sun, Juan Ma, Chulin Yu, Desheng Kong, Meng Chen, Xuejie Liu, Dandan Zhao, Shuman Gao, Shuyuan Kou, Lili Sun, Zeyong Ge, Jun Zhao, Kuokuo Li, Tao Zhang, Yanjing Zhang, Chunxia Luo, Xuefeng Li, Yang Wang, Liangzhi Xie   +19 more
doaj   +1 more source

A novel Galleria mellonella experimental model for zoonotic pathogen Brucella

Virulence, 2023
Brucellosis is a major threat to public health and animal husbandry. Several in vivo vertebrate models, such as mice, guinea pigs, and nonhuman primates, have been used to study Brucella pathogenesis, bacteria-host interactions, and vaccine efficacy ...
Shuyi Wang, Ying Yin, Xiaodong Zai, Yanfei Gu, Fengyu Guo, Fangze Shao, Yue Zhang, Yaohui Li, Ruihua Li, Jun Zhang, Junjie Xu, Wei Chen   +11 more
doaj   +1 more source

In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance

Communications Biology, 2021
Lu Shan et al. present a structure-guided approach to engineer a monovalent form of the fragment crystallizable (Fc) region of an IgG4 antibody to adapt multiple versions of half-life extension modifications and bispecific targeting.
Lu Shan, Nydia Van Dyk, Nantaporn Haskins, Kimberly M. Cook, Kim L. Rosenthal, Ronit Mazor, Sonia Dragulin-Otto, Yu Jiang, Herren Wu, William F. Dall’Acqua, Martin J. Borrok, Melissa M. Damschroder, Vaheh Oganesyan   +12 more
doaj   +1 more source

IgG Fc engineering to modulate antibody effector functions

Protein & Cell, 2017
Therapeutic monoclonal antibodies are among the most effective biotherapeutics to date. An important aspect of antibodies is their ability to bind antigen while at the same time recruit immune effector functions.
Xinhua Wang, Mary Mathieu, Randall J. Brezski   +2 more
doaj   +1 more source