Results 91 to 100 of about 4,105,290 (355)

Establishment of a pseudovirus neutralization assay based on SARS-CoV-2 S protein incorporated into lentiviral particles

Biosafety and Health, 2022
The coronavirus disease 2019 (COVID-19) is still causing a wide range of infections and deaths due to the high variability of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Sheng Wang, Lizhen Liu, Can Wang, Ziqiang Wang, Xuhua Duan, Gang Chen, Hu Zhou, Hong Shao   +7 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis [PDF]

, 2009
Antibodies to citrulline-modifi ed proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological role in disease development is still unclear.
Rikard Holmdahl, Bockermann, Robert, Hüseyin Uysal, Sehnert, Bettina,, Harald Burkhardt, Robert Bockermann, Bockermann, R, Nandakumar, Kutty S, Bajtner, Estelle,, Engstrom, A, Thunnissen, Marjolein M G M, Uysal, H,, Serre, Guy, Serre, G, Holmdahl, R,, Nandakumar, Kutty Selva,, Bajtner, E, Holmdahl, Rikard, Uysal, Hüseyin,, Burkhardt, Harald,, Burkhardt, H, Kutty Selva, Nandakumar,, Kutty S. Nandakumar, Bettina Sehnert, Thunnissen, MMGM, Serre, Guy,, Nandakumar, Kutty S., Burkhardt, Harald, Engström, Åke, Thunnissen, Marjolein,, Guy Serre, Engström, Åke,, Thunnissen, Marjolein M. G. M., Thunnissen, Marjolein M. G. M.,, Sehnert, B, Åke Engström, Sehnert, Bettina, Kutty Selva, Nandakumar, Nandakumar, KS, Estelle Bajtner, Lund University., Bajtner, Estelle, Thunnissen, Marjolein, Marjolein M.G.M. Thunnissen, Bockermann, Robert,, Holmdahl, Rikard,, Uysal, Hüseyin   +46 more
core   +1 more source

H-ferritin nanoparticle-mediated antibody delivery across the blood-brain barrier

Frontiers in Aging Neuroscience
BackgroundTherapeutic monoclonal antibodies (mAbs) show great promise for treating neurological disorders thanks to their high selectivity and potency. However, their clinical potential is significantly limited by poor penetration across the blood-brain ...
Ziwei Yuan, Laura Rué, Tom Jaspers, Marie-Lynn Cuypers, Maarten Dewilde, Maarten Dewilde   +5 more
doaj   +1 more source

Expression, Role, and Regulation of Neutrophil Fcγ Receptors

Frontiers in Immunology, 2019
Neutrophils are best known for their critical role in host defense, for which they utilize multiple innate immune mechanisms, including microbe-associated pattern recognition, phagocytosis, production of reactive oxygen species, and the release of potent
Yu Wang, Yu Wang, Friederike Jönsson
doaj   +1 more source

Identification of Immunogenic Linear B-Cell Epitopes in C. burnetii Outer Membrane Proteins Using Immunoinformatics Approaches Reveals Potential Targets of Persistent Infections

Pathogens, 2021
Coxiella burnetii is a global, highly infectious intracellular bacterium, able to infect a wide range of hosts and to persist for months in the environment. It is the etiological agent of Q fever—a zoonosis of global priority.
Sílvia da Silva Fontes, Fernanda de Moraes Maia, Laura Santa’Anna Ataides, Fernando Paiva Conte, Josué da Costa Lima-Junior, Tatiana Rozental, Matheus Ribeiro da Silva Assis, Adonai Alvino Pessoa Júnior, Jorlan Fernandes, Elba Regina Sampaio de Lemos, Rodrigo Nunes Rodrigues-da-Silva   +10 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Characterization of immunoglobulin G antibodies to Plasmodium falciparum sporozoite surface antigen MB₂ in malaria exposed individuals [PDF]

, 2009
Background MB2 protein is a sporozoite surface antigen on the human malaria parasite Plasmodium falciparum. MB2 was identified by screening a P. falciparum sporozoite cDNA expression library using immune sera from a protected donor immunized via the ...
James Anthony A, de la Vega, Patricia, John, Chandy C, Thanh V Nguyen, Nguyen, Thanh V, de la Vega, P, John B Sacci, Patricia de la Vega, James, Anthony A, Kang Angray S, John Chandy C, James, AA, Nguyen, T.V., Sacci, John B, Kang, A.S., Sacci John B, de la Vega, P., Nguyen Thanh V, Anthony A James, de la Vega Patricia, John, C.C., Kang, Angray S, Angray S Kang, Sacci, J.B., Patricia Vega, Chandy C John, John, CC, Nguyen, TV, Kang, AS, Jr, SJB, James, A.A.   +30 more
core   +1 more source

Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection

medRxiv, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread within the human population. Although SARS-CoV-2 is a novel coronavirus, most humans had been previously exposed to other antigenically distinct common seasonal human ...
E. M. Anderson, E. Goodwin, A. Verma, C. P. Arevalo, M. Bolton, M. Weirick, S. Gouma, C. McAllister, Shannon R. Christensen, J. Weaver, Phillip Hicks, Tomaz B. Manzoni, O. Oniyide, H. Ramage, D. Mathew, A. Baxter, D. Oldridge, A. Greenplate, Jennifer E. Wu, Cécile Alanio, Kurt D039, Andrea, O. Kuthuru, J. Dougherty, A. Pattekar, Justin Y. Kim, N. Han, Sokratis A. Apostolidis, Alexander C. Huang, L. Vella, -. T. U. C. P. Unit, E. Wherry, N. Meyer, S. Cherry, Paul Bates, D. Rader, S. Hensley   +36 more
semanticscholar   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source