Results 71 to 80 of about 4,105,290 (355)

Mouse Models and Tools for the in vivo Study of Neutrophils

Frontiers in Immunology, 2020
Neutrophils are the most abundant leukocytes in human blood and critical actors of the immune system. Many neutrophil functions and facets of their activity in vivo were revealed by studying genetically modified mice or by tracking fluorescent ...
Julien Stackowicz, Julien Stackowicz, Friederike Jönsson, Laurent L. Reber, Laurent L. Reber   +4 more
doaj   +1 more source

The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

Science immunology, 2020
The serum level of RBD-binding antibodies correlates with SARS-CoV-2 neutralization and can be used for population-level surveillance. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that first emerged in late 2019 is responsible for a ...
L. Premkumar, Bruno Segovia-Chumbez, R. Jadi, David R. Martinez, R. Raut, A. Markmann, Caleb Cornaby, L. Bartelt, S. Weiss, Yara Park, C. Edwards, E. Weimer, E. Scherer, N. Rouphael, S. Edupuganti, D. Weiskopf, Longping V. Tse, Yixuan J. Hou, D. Margolis, A. Sette, M. Collins, J. Schmitz, R. Baric, A. D. de Silva   +23 more
semanticscholar   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

Prevalence of anti-SARS-CoV-2 antibodies in the general population in Belgium: First results of the SalivaHIS study [PDF]

, 2021
Key findings In the beginning of July 2021 78.1% of the community dwelling population aged 18 years and above had developed anti-SARS-CoV-2 antibodies.
V. Leclercq, L. Gisle, N. Van den Houte, J. Van der Heyden   +3 more
core  

Identification, Efficacy, and Stability Evaluation of Succinimide Modification With a High Abundance in the Framework Region of Golimumab

Frontiers in Chemistry, 2022
Succinimide (Asu) is the intermediate for asparagine deamidation in therapeutic proteins, and it can be readily hydrolyzed to form aspartate and iso-aspartate residues. Moreover, Asu plays an important role in the protein degradation pathways, asparagine
Tao Liu, Tao Liu, Tao Liu, Jin Xu, Jin Xu, Jin Xu, Jin Xu, Qingcheng Guo, Dapeng Zhang, Dapeng Zhang, Dapeng Zhang, Jun Li, Weizhu Qian, Weizhu Qian, Weizhu Qian, Huaizu Guo, Huaizu Guo, Huaizu Guo, Huaizu Guo, Xinli Zhou, Sheng Hou, Sheng Hou, Sheng Hou   +22 more
doaj   +1 more source

Prospective mapping of viral mutations that escape antibodies used to treat COVID-19

bioRxiv, 2020
Antibodies are becoming a frontline therapy for SARS-CoV-2, but the risk of viral evolutionary escape remains unclear. Here we map how all mutations to SARS-CoV-2’s receptor-binding domain (RBD) affect binding by the antibodies in Regeneron’s REGN-COV2 ...
Tyler N. Starr, Allison J. Greaney, Amin Addetia, William W. Hannon, M. Choudhary, A. Dingens, Jonathan Z. Li, J. Bloom   +7 more
semanticscholar   +1 more source

The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young‐adult patients ...
Marco Salvi, Maria Carmen Affinita, Giulia Fichera, Luisa Santoro, Angela Scagnellato, Calogero Virgone, Elena Poli, Gianni Bisogno   +7 more
wiley   +1 more source

Hepatitis C virus (HCV) infection may elicit neutralizing antibodies targeting epitopes conserved in all viral genotypes [PDF]

, 2009
Anti-hepatitis C virus (HCV) cross-neutralizing human monoclonal antibodies, directed against conserved epitopes on surface E2 glycoprotein, are central tools for understanding virus-host interplay, and for planning strategies for prevention and ...
Patel, Ah, Ball Jonathan K., Nicasio Mancini, Nicola Clementi, Sautto, G, Clementi, N., Ball, J.K., Diotti, R.A., Burioni, R., Mario Perotti, Arvind H Patel, Nitti Giovanni, Diotti, Ra, Clementi Massimo, CLEMENTI, NICOLA, BURIONI, ROBERTO, Sautto, G., CLEMENTI, MASSIMO, Perotti, M., Jonathan K Ball, Massimo Clementi, Nitti, G, Giovanni Nitti, Patel, A.H., Clementi, M., Perotti Mario, Ball, Jk, Perotti, M, Patel Arvind H., Roberta A Diotti, Giuseppe Sautto, Mancini Nicasio, Diotti Roberta A., Mancini, N., Roberto Burioni, Sautto Giuseppe, MANCINI, NICASIO, Clementi Nicola, Burioni Roberto, Nitti, G.   +39 more
core   +1 more source

Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice

Nature Communications, 2021
Asthma is caused by hyperreactivity to benign antigens, with humoral immunity orchestrated by interleukin-4 (IL-4) and IL-13 being the key etiological factor.
Eva Conde, Romain Bertrand, Bianca Balbino, Jonathan Bonnefoy, Julien Stackowicz, Noémie Caillot, Fabien Colaone, Samir Hamdi, Raïssa Houmadi, Alexia Loste, Jasper B. J. Kamphuis, François Huetz, Laurent Guilleminault, Nicolas Gaudenzio, Aurélie Mougel, David Hardy, John N. Snouwaert, Beverly H. Koller, Vincent Serra, Pierre Bruhns, Géraldine Grouard-Vogel, Laurent L. Reber   +21 more
doaj   +1 more source

Novel Human/Non-Human Primate Cross-Reactive Anti-Transferrin Receptor Nanobodies for Brain Delivery of Biologics

Pharmaceutics, 2023
The blood-brain barrier (BBB), while being the gatekeeper of the central nervous system (CNS), is a bottleneck for the treatment of neurological diseases.
Laura Rué, Tom Jaspers, Isabelle M. S. Degors, Sam Noppen, Dominique Schols, Bart De Strooper, Maarten Dewilde   +6 more
doaj   +1 more source