Results 61 to 70 of about 2,598,104 (298)

Delineating Molecular Mechanisms of Squamous Tissue Homeostasis and Neoplasia: Focus on p63

Journal of Skin Cancer, 2013
Mouse models have informed us that p63 is critical for normal epidermal development and homeostasis. The p53/p63/p73 family is expressed as multiple protein isoforms due to a combination of alternative promoter usage and C-terminal alternative splicing ...
Kathryn E. King, Linan Ha, Tura Camilli, Wendy C. Weinberg   +3 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Defining Natural Antibodies

Frontiers in Immunology, 2017
The traditional definition of natural antibodies (NAbs) states that these antibodies are present prior to the body encountering cognate antigen, providing a first line of defense against infection thereby, allowing time for a specific antibody response ...
Nichol E. Holodick, Nely Rodríguez-Zhurbenko, Ana María Hernández   +2 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Hepatitis C virus (HCV) infection may elicit neutralizing antibodies targeting epitopes conserved in all viral genotypes [PDF]

, 2009
Anti-hepatitis C virus (HCV) cross-neutralizing human monoclonal antibodies, directed against conserved epitopes on surface E2 glycoprotein, are central tools for understanding virus-host interplay, and for planning strategies for prevention and ...
Patel, Ah, Ball Jonathan K., Nicasio Mancini, Nicola Clementi, Sautto, G, Clementi, N., Ball, J.K., Diotti, R.A., Burioni, R., Mario Perotti, Arvind H Patel, Nitti Giovanni, Diotti, Ra, Clementi Massimo, CLEMENTI, NICOLA, BURIONI, ROBERTO, Sautto, G., CLEMENTI, MASSIMO, Perotti, M., Jonathan K Ball, Massimo Clementi, Nitti, G, Giovanni Nitti, Patel, A.H., Clementi, M., Perotti Mario, Ball, Jk, Perotti, M, Patel Arvind H., Roberta A Diotti, Giuseppe Sautto, Mancini Nicasio, Diotti Roberta A., Mancini, N., Roberto Burioni, Sautto Giuseppe, MANCINI, NICASIO, Clementi Nicola, Burioni Roberto, Nitti, G.   +39 more
core   +1 more source

Prestige Antibodies™—Monospecific Antibodies Designed for Immunohistochemical Analysis

BioTechniques, 2008
Sara A. Gunnerås, Charlotta Agaton, Soraya Djerbi, Marianne Hansson   +3 more
doaj   +5 more sources

Impact of cellular proteases on the function of antiviral antibodies

Journal of Virology
Viruses evade antibodies through many mechanisms. While mutation remains the predominant pathway, host proteases can be hijacked upon viral infections and decrease antibody-mediated clearance.
Mateo Krzypow, Olivier Schwartz, Timothée Bruel, Andréa Cottignies-Calamarte   +3 more
doaj   +1 more source

Correction: Mehrling, T.; et al. Challenges in Optimising the Successful Construction of Antibody Drug Conjugates in Cancer Therapy. Antibodies 2018, 7, 11

Antibodies, 2018
The Conflict of Interest section of the published paper [1] has been updated as follows: [...]
Thomas Mehrling, Daniel Soltis, the Antibodies Editorial Office   +2 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Differences in affinity of monoclonal and naturally acquired polyclonal antibodies against Plasmodium falciparum merozoite antigens [PDF]

, 2015
Malaria is a major global cause of deaths and a vaccine is urgently needed.; We have employed the P. falciparum merozoite antigens MSP2-3D7/FC27 and AMA1, used them in ELISA, and coupled them in different ways using surface plasmon resonance (SPR) and ...
Stanisic, Danielle, Kironde, Fred, Danielle I. Stanisic, Anders, Robin F, Reddy, Sreenivasulu B, Persson, Kristina, Sreenivasulu B. Reddy, Cross, Nadia, Mats Wahlgren, Anders, Robin F., Cross, N, Beeson, James G, Wahlgren, M, Senn, Nicolas, Senn, N, Nicolas Senn, Kristina E.M. Persson, Reddy, SB, Stanisic, DI, Wahlgren, Mats, Nadia Cross, Fred Kironde, Beeson, JG, Persson, KEM, Mueller, Ivo, Reddy, Sreenivasulu B., Ivo Mueller, Peter M. Siba, Kironde, F, Siba, Peter M, Mueller, I, Siba, PM, Stanisic, Danielle I, Stanisic, Danielle I., Persson, Kristina,, Robin F. Anders, James G. Beeson, Siba, Peter M., Persson, Kristina E. M., Lund University., Beeson, James G., Anders, RF   +41 more
core   +1 more source