Results 61 to 70 of about 4,105,290 (355)

Serum antibodies in first-degree relatives of patients with IBD: A marker of disease susceptibility? A follow-up pilot-study after 7 years [PDF]

, 2005
Introduction: Various disease-specific serum antibodies were described in patients with inflammatory bowel disease and their yet healthy first-degree relatives.
Török, H.-P., Folwaczny, Christian, Bruckl, C., Folwaczny, Matthias, Mussack, T., Glas, J., Gruber, R., Osthoff, M., Tonenchi, L., Hollay, H. C.   +9 more
core   +1 more source

Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies

Cell, 2020
Summary Neutralizing antibody responses to coronaviruses mainly target the receptor-binding domain (RBD) of the trimeric spike. Here, we characterized polyclonal immunoglobulin Gs (IgGs) and Fabs from COVID-19 convalescent individuals for recognition of ...
C. Barnes, A. West, Kathryn E Huey-Tubman, Magnus A. G. Hoffmann, N. G. Sharaf, Pauline R. Hoffman, Nicholas S Koranda, H. Gristick, C. Gaebler, Frauke Muecksch, J. C. Lorenzi, Shlomo Finkin, Thomas Hägglöf, A. Hurley, Katrina G. Millard, Y. Weisblum, F. Schmidt, T. Hatziioannou, P. Bieniasz, M. Caskey, D. Robbiani, M. Nussenzweig, P. Bjorkman   +22 more
semanticscholar   +1 more source

Antibodies to the Mr 64,000 (64K) protein in islet cell antibody positive non-diabetic individuals indicate high risk for impaired Beta-cell function [PDF]

, 1992
A prospective study of a normal childhood population identified 44 islet cell antibody positive individuals. These subjects were typed for HLA DR and DQ alleles and investigated for the presence of antibodies to the Mr 64,000 (64K) islet cell antigen ...
Glück, Michael, Bretzel, Reinhard G., Federlin, Konrad, Seißler, Jochen, Hering, Bernhard J., Böhm, Bernhard Otto, Yassin, Nuha, Scherbaum, Werner A., Richter, Wiltrud   +8 more
core   +1 more source

LICHEN enables light-chain immunoglobulin sequence generation conditioned on the heavy chain and experimental needs

Communications Biology
In developing therapeutic antibodies, the heavy chain is often prioritised due to its higher variability and its central role in antigen binding. An appropriate pairing of the light sequence is however important for antibody function.
Henriette L. Capel, Isaac Ellmen, Chris J. Murray, Giulia Mignone, Megan Black, Brendan Clarke, Conor Breen, Sean Tierney, Patrick Dougan, Richard J. Buick, Alexander Greenshields-Watson, Charlotte M. Deane   +11 more
doaj   +1 more source

Isolation methods determine human neutrophil responses after stimulation

Frontiers in Immunology, 2023
Studying neutrophils is challenging due to their limited lifespan, inability to proliferate, and resistance to genetic manipulation. Neutrophils can sense various cues, making them susceptible to activation by blood collection techniques, storage ...
Vanessa Krémer, Vanessa Krémer, Ophélie Godon, Pierre Bruhns, Friederike Jönsson, Friederike Jönsson, Luc de Chaisemartin, Luc de Chaisemartin, Luc de Chaisemartin   +8 more
doaj   +1 more source

Association Between Dinutuximab Beta Exposure and Post‐End‐of‐Treatment Survival in Neuroblastoma: A Weighted Patient‐Level Analysis of Three Clinical Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives The association between exposure to dinutuximab beta (DB) and event‐free survival (EFS) or overall survival (OS) of neuroblastoma patients was assessed using data collected during three clinical trials (five cohorts). Methods A systematic review (March 2026) was conducted to identify relevant studies (prospective; registered DB ...
Przemysław Holko, Holger N. Lode, Alberto Garaventa, Carla Manzitti, Roberto Luksch, Dominique Valteau‐Couanet, Marion Gambart, John Anderson, Juliet Gray, Adela Canete, Lucas Moreno, Aleksandra Wieczorek, Cormac Owens, Shifra Ash, Isaac Yaniv, Genevieve Laureys, Hans Loibner, Katarzyna Śladowska, Ruth Ladenstein, Paweł Kawalec   +19 more
wiley   +1 more source

Thinking Outside the Box to Obtain the Best Antibodies! [PDF]

, 2021
Monoclonal Antibodies Laboratory Department of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara Jau KM01Monoclonal Antibodies Laboratory Department of Clinical Analysis School of Pharmaceutical ...
Moroz, Andrei [UNESP]
core   +1 more source

The Antitumor Activity of Combinations of Cytotoxic Chemotherapy and Immune Checkpoint Inhibitors Is Model-Dependent

Frontiers in Immunology, 2018
In spite of impressive response rates in multiple cancer types, immune checkpoint inhibitors (ICIs) are active in only a minority of patients. Alternative strategies currently aim to combine immunotherapies with conventional agents such as cytotoxic ...
Chloé Grasselly, Chloé Grasselly, Morgane Denis, Morgane Denis, Aurore Bourguignon, Aurore Bourguignon, Nolan Talhi, Doriane Mathe, Anne Tourette, Laurent Serre, Lars Petter Jordheim, Eva Laure Matera, Charles Dumontet, Charles Dumontet   +13 more
doaj   +1 more source

Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A Global Consortium study

Science, 2021
Description Community of antibodies against COVID-19 The severe acute respiratory syndrome coronavirus 2 spike protein is the basis of many vaccines and is a primary target of neutralizing antibodies after COVID-19 infection.
K. Hastie, Haoyang Li, Daniel H Bedinger, S. Schendel, S. Dennison, Kan Li, V. Rayaprolu, Xiaoying Yu, Colin J. Mann, M. Zandonatti, Ruben Diaz Avalos, D. Żyła, Tierra Buck, S. Hui, K. Shaffer, C. Hariharan, Jieyun Yin, Eduardo Olmedillas, Adrian Enriquez, D. Parekh, Milite Abraha, Elizabeth Feeney, G. Horn, Y. Aldon, Hanif Ali, Sanja Aracic, Ronald R Cobb, Ross S. Federman, Joseph M. Fernandez, J. Glanville, R. Green, G. Grigoryan, Ana G. Lujan Hernandez, D. Ho, Kuan-Ying A. Huang, J. Ingraham, Weidong Jiang, P. Kellam, Cheolmin Kim, Minsoo Kim, Hyeong Mi Kim, Chao Kong, S. Krebs, F. Lan, Guojun Lang, Sooyoung Lee, Cheuk Lun Leung, Junli Liu, Yanan Lu, Anna J. MacCamy, A. McGuire, A. Palser, T. Rabbitts, Zahra Rikhtegaran Tehrani, Mohammad M. Sajadi, R. Sanders, A. Sato, L. Schweizer, Jimin Seo, Bingqing Shen, Jonne L. Snitselaar, L. Stamatatos, Yongcong Tan, M. Tomic, M. V. van Gils, S. Youssef, Jian Yu, Tom Z. Yuan, Qian Zhang, B. Peters, G. Tomaras, T. Germann, E. Saphire   +72 more
semanticscholar   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source