Results 41 to 50 of about 4,329,929 (348)

SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

Nature, 2021
An ideal therapeutic anti-SARS-CoV-2 antibody would resist viral escape1–3, have activity against diverse sarbecoviruses4–7, and be highly protective through viral neutralization8–11 and effector functions12,13.
Tyler N. Starr, N. Czudnochowski, Zhuo-Ming Liu, F. Zatta, Young-Jun Park, Amin Addetia, D. Pinto, M. Beltramello, P. Hernandez, Allison J. Greaney, R. Marzi, William G. Glass, Ivy Zhang, Adam S. Dingens, J. Bowen, M. A. Tortorici, A. Walls, Jason A. Wojcechowskyj, A. De Marco, L. E. Rosen, Jia-Yi Zhou, Martin Montiel-Ruiz, Hannah Kaiser, J. Dillen, H. Tucker, Jessica Bassi, Chiara Silacci-Fregni, M. Housley, J. di Iulio, Gloria Lombardo, Maria L. Agostini, Nicole Sprugasci, K. Culap, S. Jaconi, M. Meury, Exequiel Dellota, R. Abdelnabi, S. Foo, E. Cameroni, S. Stumpf, T. Croll, J. Nix, C. Havenar-Daughton, L. Piccoli, F. Benigni, J. Neyts, A. Telenti, F. Lempp, M. Pizzuto, J. Chodera, C. Hebner, H. Virgin, Sean P. J. Whelan, D. Veesler, D. Corti, J. Bloom, G. Snell   +56 more
semanticscholar   +1 more source

No association between islet cell antibodies and coxsackie B, mumps, rubella and cytomegalovirus antibodies in non-diabetic individuals aged 7–19 years [PDF]

, 1991
Viral antibodies were tested in a cohort of 44 isletcell antibody-positive individuals age 7–19 years, and 44 of their islet cell antibody-negative age and sex-matched classmates selected from a population study of 4208 pupils who had been screened for ...
Muir, Peter, Glück, Michael, Seißler, Jochen, Heinze, Eberhard, Hampl, Walter, Egle, H., Pfeiffer, Ernst Friedrich, Böhm, Bernhard Otto, Banatvala, Jangu E., Scherbaum, Werner A., Hauner, Hans   +10 more
core   +1 more source

Isotype specific ELISAs to detect antibodies against swine vesicular disease virus and their use in epidemiology [PDF]

, 2002
Isotype specific ELISAs to detect antibodies against swine vesicular disease, which may help to estimate the moment of infection, were developed and validated on sera from pigs experimentally infected with four different isolates of swine vesicular ...
Dekker, A., Hemert-Kluitenberg, F., van, Terpstra, C., Baars-Lorist, C.A.   +3 more
core   +1 more source

Isolation of a human SARS-CoV-2 neutralizing antibody from a synthetic phage library and its conversion to fluorescent biosensors

Scientific Reports, 2022
Since late 2019, the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resultant spread of COVID-19 have given rise to a worldwide health crisis that is posing great challenges to public health and clinical treatment, in ...
Haimei Li, Bo Zhu, Baowei Li, Limei Chen, Xuerao Ning, Hang Dong, Jingru Liang, Xueying Yang, Jinhua Dong, Hiroshi Ueda   +9 more
doaj   +1 more source

Anti-phospholipid-antibodies in patients with relapsing polychondritis [PDF]

, 1998
Relapsing polychondritis (RP) is an extremly rare multisystemic disease thought to be of autoimmune origin. In order to assess if RP is associated with anti-phospholipid antibodies (aPL), clinical data and sera of 21 patients with RP were collected in a ...
Schlosser, U., Schmitz, G., Lang, B., Zeuner, M., Straub, R. H., Rauh, G., Schòlmerich, J.   +6 more
core   +1 more source

Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate [PDF]

, 2012
The majority of broadly neutralizing antibodies to hepatitis C virus (HCV) are against conformational epitopes on the E2 glycoprotein. Many of them recognize overlapping epitopes in a cluster, designated as antigenic domain B, that contains residues G530
Wenyan Wang (171659), Bukh, J., Felix A Rey, Yong Wang (12837), Wang, Yong, Zhen-yong Keck (171653), Jannick Prentoe (162323), Lemon, S.M., Jannick Prentoe, Jens Bukh (162343), Steven K. H. Foung (171667), Lemon, Stanley M., Prentoe Jannick, Foung Steven K. H., Thomas Carlsen (171662), Carlsen, Thomas, Rey, F.A., Patel, Arvind H., Li, A.Y., Patel, A.H., Steven K H Foung, Carlsen Thomas, Bukh, Jens, Xia, J., Zhen-yong Keck, Li, Angela Ying-Jian, Wenyan Wang, Keck, Zhen-yong, Thomas Krey, Wang, Y., Rey Felix A., Yong Wang, Foung, S.K.H., Arvind H. Patel (33806), Patel, Arvind H, Lemon, Stanley M, Krey Thomas, Keck Zhen-yong, Wang Wenyan, Rey, Felix A., Prentoe, Jannick, Arvind H Patel, Bukh Jens, Stanley M Lemon, Krey, T., Angela Ying-Jian Li, Felix A. Rey (171664), Foung, Steven K H, Thomas Krey (171661), Keck, Z., Xia Jinming, Krey, Thomas, Jinming Xia (171656), Stanley M. Lemon (30543), Wang, Wenyan, Lemon Stanley M., Patel Arvind H., Rey, Felix A, Li Angela Ying-Jian, Jinming Xia, Xia, Jinming, Foung, Steven K. H., Thomas Carlsen, Wang, W., Prentoe, J., Jens Bukh, Angela Ying-Jian Li (171663), Carlsen, T., Wang Yong   +68 more
core   +1 more source

A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2

Science, 2020
An antibody defense against COVID-19 One of the responses of the immune system to invading viruses is the production of antibodies. Some of these are neutralizing, meaning that they prevent the virus from being infectious, and can thus be used to treat ...
Yan Wu, Feiran Wang, Chen-Guang Shen, Weiyu Peng, Delin Li, Cheng Zhao, Zhao Li, Shi-Hua Li, Y. Bi, Yang Yang, Yuhuan Gong, Hai-Xia Xiao, Zheng Fan, Shu-Guang Tan, Gui-Zhen Wu, W. Tan, Xuan-Cheng Lu, Chang-Fa Fan, Qi-Hui Wang, Ying-Xia Liu, Chen Zhang, J. Qi, G. Gao, F. Gao, Lei Liu   +24 more
semanticscholar   +1 more source

Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies

Lancet Neurology, 2008
Summary Background A severe form of encephalitis associated with antibodies against NR1–NR2 heteromers of the NMDA receptor was recently identified. We aimed to analyse the clinical and immunological features of patients with the disorder and examine the
J. Dalmau, Amy J. Gleichman, E. Hughes, J. E. Rossi, Xiaoyu Peng, Mei-Zan Lai, S. Dessain, M. Rosenfeld, R. Balice-Gordon, D. Lynch   +9 more
semanticscholar   +1 more source

Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-Polyethylene Glycol Antibodies.

ACS Nano, 2021
Polyethylene glycol (PEG) is a flexible, hydrophilic simple polymer that is physically attached to peptides, proteins, nucleic acids, liposomes, and nanoparticles to reduce renal clearance, block antibody and protein binding sites, and enhance the half ...
Bing-Mae Chen, Tian-Lu Cheng, S. Roffler
semanticscholar   +1 more source

Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies

Nature Communications, 2021
Monoclonal antibodies targeting a variety of epitopes have been isolated from individuals previously infected with SARS-CoV-2, but the relative contributions of these different antibody classes to the polyclonal response remains unclear.
Allison J. Greaney, Tyler N. Starr, C. Barnes, Yiska Weisblum, Fabian Schmidt, M. Caskey, C. Gaebler, Alice Cho, Marianna Agudelo, Shlomo Finkin, Zi-Jun Wang, D. Poston, Frauke Muecksch, T. Hatziioannou, P. Bieniasz, D. Robbiani, M. Nussenzweig, P. Bjorkman, J. Bloom   +18 more
semanticscholar   +1 more source