Results 21 to 30 of about 4,105,290 (355)

Acknowledgment to the Reviewers of Antibodies in 2022

Antibodies, 2023
High-quality academic publishing is built on rigorous peer review [...]
Antibodies Editorial Office
doaj   +1 more source

Peptides, Antibodies, Peptide Antibodies and More [PDF]

International Journal of Molecular Sciences, 2019
The applications of peptides and antibodies to multiple targets have emerged as powerful tools in research, diagnostics, vaccine development, and therapeutics. Antibodies are unique since they, in theory, can be directed to any desired target, which illustrates their versatile nature and broad spectrum of use as illustrated by numerous applications of ...
Nicole Trier, Paul Hansen, Gunnar Houen
openaire   +3 more sources

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

Nature, 2021
The recently emerged SARS-CoV-2 Omicron variant encodes 37 amino acid substitutions in the spike protein, 15 of which are in the receptor-binding domain (RBD), thereby raising concerns about the effectiveness of available vaccines and antibody-based ...
E. Cameroni, John E. Bowen, Laura E. Rosen, C. Saliba, Samantha K. Zepeda, K. Culap, D. Pinto, L. VanBlargan, A. De Marco, J. di Iulio, F. Zatta, Hannah Kaiser, Julia Noack, Nisar Farhat, N. Czudnochowski, C. Havenar-Daughton, Kaitlin R. Sprouse, J. Dillen, Abigail E. Powell, Alex K Chen, Cyrus Maher, Li Yin, Dandan Sun, L. Soriaga, J. Bassi, C. Silacci-Fregni, C. Gustafsson, N. Franko, J. Logue, N. Iqbal, I. Mazzitelli, J. Geffner, R. Grifantini, H. Chu, A. Gori, A. Riva, O. Giannini, A. Ceschi, P. Ferrari, Pietro E. Cippà, A. Franzetti-Pellanda, C. Garzoni, P. Halfmann, Y. Kawaoka, C. Hebner, L. Purcell, L. Piccoli, M. Pizzuto, A. Walls, M. Diamond, A. Telenti, H. Virgin, A. Lanzavecchia, G. Snell, D. Veesler, D. Corti   +55 more
semanticscholar   +1 more source

Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19

New England Journal of Medicine, 2020
Coagulopathy in Critical Illness with Covid-19 The authors describe a 69-year-old man with Covid-19 diagnosed in January 2020 in Wuhan, China, along with two other critically ill patients with Covid-19 who were also seen in the same intensive care unit ...
Yan Zhang, M. Xiao, Shulan Zhang, P. Xia, W. Cao, Wei Jiang, Huan Chen, X. Ding, Hua Zhao, Hongmin Zhang, Chun-yao Wang, Jing Zhao, Xuefeng Sun, R. Tian, Wei Wu, Dong Wu, Jie Ma, Yu Chen, D. Zhang, Jing Xie, Xiaowei Yan, Xiang Zhou, Zheng-yin Liu, Jinglan Wang, B. Du, Yan Qin, Peng Gao, Xuzhen Qin, Yingchun Xu, Wen Zhang, Taisheng Li, Fengchun Zhang, Yongqiang Zhao, Yongzhe Li, Shuyang Zhang   +34 more
semanticscholar   +1 more source

Comprehensive mapping of mutations to the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human serum antibodies

bioRxiv, 2021
The evolution of SARS-CoV-2 could impair recognition of the virus by human antibody-mediated immunity. To facilitate prospective surveillance for such evolution, we map how convalescent serum antibodies are impacted by all mutations to the spike’s ...
Allison J. Greaney, Andrea N. Loes, K. H. Crawford, Tyler N. Starr, Keara D. Malone, H. Chu, J. Bloom   +6 more
semanticscholar   +1 more source

Fast, accurate antibody structure prediction from deep learning on massive set of natural antibodies

bioRxiv, 2022
Prediction of antibody structures is critical for understanding and designing novel therapeutic and diagnostic molecules. Here, the authors present IgFold: a fast, accurate method for antibody structure prediction using an end-to-end deep learning model.
Jeffrey A. Ruffolo, Lee-Shin Chu, S. Mahajan, Jeffrey J. Gray   +3 more
semanticscholar   +1 more source

Development of therapeutic antibodies for the treatment of diseases

Journal of Biomedical Sciences, 2020
It has been more than three decades since the first monoclonal antibody was approved by the United States Food and Drug Administration (US FDA) in 1986, and during this time, antibody engineering has dramatically evolved.
Ruei-Min Lu, Yu-Chyi Hwang, I. Liu, Chi-Chiu Lee, Han-zen Tsai, Hsin-Jung Li, Han‐Chung Wu   +6 more
semanticscholar   +1 more source

Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

Science, 2020
An antibody cocktail against SARS-CoV-2 There is an urgent focus on antibodies that target the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral spike and prevent the virus from entering host cells. Hansen et al.
A. Baum, Benjamin O. Fulton, Elzbieta Wloga, R. Copin, Kristen E. Pascal, Vincenzo Russo, Stephanie Giordano, Kathryn Lanza, Nicole Negron, M. Ni, Yi Wei, G. Atwal, A. Murphy, N. Stahl, G. Yancopoulos, C. Kyratsous   +15 more
semanticscholar   +1 more source

Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

Science, 2020
Protective neutralizing antibodies Antibodies produced by survivors of coronavirus disease 2019 (COVID-19) may be leveraged to develop therapies. A first step is identifying neutralizing antibodies, which confer strong protection against severe acute ...
T. Rogers, Fangzhu Zhao, Deli Huang, N. Beutler, Alison Burns, Wan-ting He, Oliver Limbo, Chloe Smith, G. Song, J. Woehl, Linlin Yang, Robert K. Abbott, Sean Callaghan, Elijah Garcia, Jonathan Hurtado, M. Parren, Linghang Peng, S. Ramirez, James Ricketts, M. Ricciardi, Stephen A. Rawlings, N. Wu, M. Yuan, Davey M. Smith, D. Nemazee, J. Teijaro, J. Voss, I. Wilson, Raiees Andrabi, Bryan S. Briney, E. Landais, D. Sok, Joseph G. Jardine, D. Burton   +33 more
semanticscholar   +1 more source

Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine

medRxiv, 2022
Humans commonly have low level antibodies to poly(ethylene) glycol (PEG) due to environmental exposure. Lipid nanoparticle mRNA vaccines for SARS-CoV-2 contain small amounts of PEG but it is not known if PEG antibodies are enhanced by vaccination and if ...
Yi Ju, W. Lee, Emily H. Pilkington, Hannah G. Kelly, Shiyao Li, K. Selva, Kathleen M. Wragg, K. Subbarao, Thi H. O. Nguyen, L. Rowntree, L. Allen, K. Bond, D. Williamson, N. Truong, M. Plebanski, K. Kedzierska, S. Mahanty, A. Chung, F. Caruso, A. Wheatley, J. Juno, S. Kent   +21 more
semanticscholar   +1 more source