Results 51 to 60 of about 4,329,929 (348)

Human monoclonal islet specific autoantibodies share features of islet cell and 64 kDa antibodies [PDF]

, 1993
The first human monoclonal islet cell antibodies of the IgG class (MICA 1-6) obtained from an individual with Type 1 (insulin-dependent) diabetes mellitus were cytoplasmic islet cell antibodies selected by the indirect immunofluorescence test on pancreas
Brandt, M., Seißler, Jochen, Jungfer, Herbert, Eiermann, Thomas H., Wolfahrt, S., Endl, Josef, Scherbaum, Werner A., Richter, Wiltrud   +7 more
core   +1 more source

Antibodies to the Mr 64,000 (64K) protein in islet cell antibody positive non-diabetic individuals indicate high risk for impaired Beta-cell function [PDF]

, 1992
A prospective study of a normal childhood population identified 44 islet cell antibody positive individuals. These subjects were typed for HLA DR and DQ alleles and investigated for the presence of antibodies to the Mr 64,000 (64K) islet cell antigen ...
Glück, Michael, Bretzel, Reinhard G., Federlin, Konrad, Seißler, Jochen, Hering, Bernhard J., Böhm, Bernhard Otto, Yassin, Nuha, Scherbaum, Werner A., Richter, Wiltrud   +8 more
core   +1 more source

Cancer therapy with antibodies

Nature Reviews. Cancer
The greatest challenge in cancer therapy is to eradicate cancer cells with minimal damage to normal cells. Targeted therapy has been developed to meet that challenge, showing a substantially increased therapeutic index compared with conventional cancer ...
Suman Paul, Maximilian F. Konig, D. Pardoll, C. Bettegowda, N. Papadopoulos, Katharine M. Wright, Sandra B. Gabelli, M. Ho, A. van Elsas, Shi-Bin Zhou   +9 more
semanticscholar   +1 more source

Rapid Decay of Anti–SARS-CoV-2 Antibodies in Persons with Mild Covid-19

New England Journal of Medicine, 2020
Covid-19 Antibodies after Mild Infection Among 34 volunteers who had recovered from mild Covid-19 illness, antiviral antibodies to the receptor-binding domain of the viral spike protein declined wi...
F. Ibarrondo, Jennifer A. Fulcher, David Goodman-Meza, J. Elliott, C. Hofmann, M. A. Hausner, Kathie G. Ferbas, Nicole H. Tobin, Grace M. Aldrovandi, Otto O. Yang   +9 more
semanticscholar   +1 more source

In Vivo Emergence of HIV-1 Highly Sensitive to Neutralizing Antibodies [PDF]

, 2011
Background: The rapid and continual viral escape from neutralizing antibodies is well documented in HIV-1 infection. Here we report in vivo emergence of viruses with heightened sensitivity to neutralizing antibodies, sometimes paralleling the development
O'Farrell Stephen, Pellegrino, P, Williams Ian, Williams, IG, Kelly M Cheney, Áine McKnight, Anna Forsman, Cheney, Kelly M, McKnight, Áine, Cheney Kelly M., Hué, Stéphane, Forsman Anna, Marlén M I Aasa-Chapman, McKnight, A, Marlén M. I. Aasa-Chapman, Ian Williams, Aasa-Chapman, Marlén MI, Cheney, KM, O'Farrell, S, Stéphane Hué, Kelly M. Cheney, Pellegrino, Pierre, Stephen O'Farrell, Forsman, A, O'Farrell, Stephen, Pierre Pellegrino, Williams, Ian, Forsman, Anna, Aasa-Chapman Marlén M. I., Aasa-Chapman, MMI, Hué Stéphane, McKnight Áine, Pellegrino Pierre, Williams, I, Hue, S, Aasa-Chapman, MM   +35 more
core   +1 more source

Anti-drug antibodies to antibody-based therapeutics in multiple sclerosis.

, 2021
Multiple sclerosis is the major demyelinating autoimmune disease of the central nervous system. Relapsing MS can be treated by a number of approved monoclonal antibodies that currently target: CD20, CD25 (withdrawn), CD49d and CD52.
Asardag, AN, Baker, D, Efimov, A, Kang, AS, Quinn, OA, Alex Efimov, A. Nazli Asardag, Olivia A. Quinn, David Baker, Angray S. Kang   +9 more
core   +1 more source

Robust neutralizing antibodies to SARS-CoV-2 infection persist for months

Science, 2020
SARS-CoV-2 antibodies persist As the number of daily COVID-19 cases continues to mount worldwide, the nature of the humoral immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains uncertain. Wajnberg et al.
A. Wajnberg, Fatima Amanat, A. Firpo, D. Altman, M. Bailey, M. Mansour, Meagan McMahon, P. Meade, D. Mendu, K. Muellers, D. Stadlbauer, K. Stone, S. Strohmeier, V. Simon, J. Aberg, D. Reich, F. Krammer, C. Cordon-Cardo   +17 more
semanticscholar   +1 more source

Plasmodium falciparum:Rosettes do not protect merozoites from invasion-inhibitory antibodies [PDF]

, 2006
Rosetting is a parasite adhesion phenotype associated with severe malaria in African children. Why parasites form rosettes is unknown, although enhanced invasion or immune evasion have been suggested as possible functions.
Rowe, J Alexandra; id_orcid, Deans, Anne-Marie   +1 more
core   +1 more source

Thinking Outside the Box to Obtain the Best Antibodies!

, 2021
Monoclonal Antibodies Laboratory Department of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara Jau KM01Monoclonal Antibodies Laboratory Department of Clinical Analysis School of Pharmaceutical ...
Moroz, Andrei [UNESP], Andrei Moroz
core   +1 more source

Monoclonal Antibodies in Cancer Therapy

Antibodies, 2020
Monoclonal antibody-based immunotherapy is now considered to be a main component of cancer therapy, alongside surgery, radiation, and chemotherapy. Monoclonal antibodies possess a diverse set of clinically relevant mechanisms of action.
D. Zahavi, L. Weiner
semanticscholar   +1 more source