Results 131 to 140 of about 4,329,929 (348)

Detection of Antibodies against H5 and H7 strains in Birds: Evaluation of Influenza Pseudovirus Particle Neutralization Tests [PDF]

, 2014
Introduction: Avian influenza viruses circulate in bird populations, and it is important to maintain and uphold our knowledge of the viral strains that are currently of interest in this context.
Lundkvist, Åke,, Karlsson, Malin, Leijon, Mikael, Temperton, Nigel J, Lagerqvist, Nina, Cassmer, Michaela, Wallerström, Sofie, Moreno, Ana, Falk, Kerstin I, Cassmer, M, Leijon, M, Wallerström, S, Lundkvist, A, Moreno, A, Karlsson, M, Lagerqvist, N,, Temperton, NJ, Falk, KI, Temperton, Nigel J., Lundkvist, Åke, Falk, Kerstin   +20 more
core   +1 more source

The making of bispecific antibodies

mAbs, 2017
During the past two decades we have seen a phenomenal evolution of bispecific antibodies for therapeutic applications. The ‘zoo’ of bispecific antibodies is populated by many different species, comprising around 100 different formats, including small ...
U. Brinkmann, R. Kontermann
semanticscholar   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Antibody Engineering for the Development of Therapeutic Antibodies

Molecules and Cells, 2005
Therapeutic antibodies represent one of the fastest growing areas of the pharmaceutical industry. There are currently 19 monoclonal antibodies in the market that have been approved by the FDA and over 150 in clinical developments. Driven by innovation and technological developments, therapeutic antibodies are the second largest biopharmaceutical ...
Sang Jick, Kim, Youngwoo, Park, Hyo Jeong, Hong   +2 more
openaire   +2 more sources

Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein

Fluids and Barriers of the CNS
Background Therapeutic antibodies for the treatment of neurological disease show great potential, but their applications are rather limited due to limited brain exposure.
Marie-Lynn Cuypers, Tom Jaspers, Jarne Clerckx, Simon Leekens, Christopher Cawthorne, Guy Bormans, Frederik Cleeren, Nick Geukens, Bart De Strooper, Maarten Dewilde   +9 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Antibodies for immunolabeling by light and electron microscopy : not for the faint hearted [PDF]

, 2014
Reliable antibodies represent crucial tools in the arsenal of the cell biologist and using them to localize antigens for immunocytochemistry is one of their most important applications.
Lucocq, John Milton, Griffiths, Gareth, John Milton Lucocq, Gareth Griffiths   +3 more
core   +1 more source

Publisher Correction: An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

Nature Communications, 2019
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Chang-Han Lee, Tae Hyun Kang, Ophélie Godon, Makiko Watanabe, George Delidakis, Caitlin M. Gillis, Delphine Sterlin, David Hardy, Michel Cogné, Lynn E. Macdonald, Andrew J. Murphy, Naxin Tu, Jiwon Lee, Jonathan R. McDaniel, Emily Makowski, Peter M. Tessier, Aaron S. Meyer, Pierre Bruhns, George Georgiou   +18 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Differences in affinity of monoclonal and naturally acquired polyclonal antibodies against Plasmodium falciparum merozoite antigens [PDF]

, 2015
Malaria is a major global cause of deaths and a vaccine is urgently needed.; We have employed the P. falciparum merozoite antigens MSP2-3D7/FC27 and AMA1, used them in ELISA, and coupled them in different ways using surface plasmon resonance (SPR) and ...
Stanisic, Danielle, Kironde, Fred, Danielle I. Stanisic, Anders, Robin F, Reddy, Sreenivasulu B, Persson, Kristina, Sreenivasulu B. Reddy, Cross, Nadia, Mats Wahlgren, Anders, Robin F., Cross, N, Beeson, James G, Wahlgren, M, Senn, Nicolas, Senn, N, Nicolas Senn, Kristina E.M. Persson, Reddy, SB, Stanisic, DI, Wahlgren, Mats, Nadia Cross, Fred Kironde, Beeson, JG, Persson, KEM, Mueller, Ivo, Reddy, Sreenivasulu B., Ivo Mueller, Peter M. Siba, Kironde, F, Siba, Peter M, Mueller, I, Siba, PM, Stanisic, Danielle I, Stanisic, Danielle I., Persson, Kristina,, Robin F. Anders, James G. Beeson, Siba, Peter M., Persson, Kristina E. M., Lund University., Beeson, James G., Anders, RF, Wahlgren, M,   +42 more
core   +1 more source